4YC4

Crystal structure of phosphatidyl inositol 4-kinase II alpha in complex with nucleotide analog

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Phosphatidylinositol 4-kinase type 2-alpha,Lysozyme,Phosphatidylinositol 4-kinase type 2-alpha	polymer	556	63240.9	1	UniProt (Q9BTU6) UniProt (D9IEF7) Pfam (PF00454) Pfam (PF00959) In PDB	Homo sapiens (Human)	Phosphatidylinositol 4-kinase type II-alpha,Phosphatidylinositol 4-kinase type II-alpha
2	A	[(1S,3S,4S)-3-(6-amino-9H-purin-9-yl)bicyclo[2.2.1]hept-1-yl]methanol	non-polymer		259.3	1	Chemie (M59)
3	A	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
4		water	water		18.0	3	Chemie (HOH)

Sequence modifications

A: 76 - 172 (UniProt: Q9BTU6)

PDB	External Database	Details
Gly 72	-	expression tag
Ala 73	-	expression tag
Met 74	-	expression tag
Gly 75	-	expression tag

A: 1004 - 1166 (UniProt: D9IEF7)

PDB	External Database	Details
Thr 1056	Cys 54	conflict
Ala 1099	Cys 97	conflict

A: 180 - 468 (UniProt: Q9BTU6)

PDB	External Database	Details
Gly 1001	-	linker
Thr 1002	-	linker
Gly 1003	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	63240.9
Non-Polymers*	Number of molecules	2
	Total formula weight	686.5
All*	Total formula weight	63927.4

*Water molecules are not included.