8K4Z

Crystal structure of human MMP-7 in complex with inhibitor

Summary for 8K4Z

• Entry DOI: 10.2210/pdb8k4z/pdb
• Descriptor: Matrilysin, Inhibitor, CALCIUM ION, ... (7 entities in total)
• Functional Keywords: matrilysin, matrin, matrix metalloproteinase-7, pump-1 protease, uterine metalloproteinase, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 20545.28

Authors

Kamitani, M.,Mima, M.,Oka, Y. (deposition date: 2023-07-20, release date: 2024-04-17)

• Primary citation: Oka, Y.,Abe-Sato, K.,Tabuse, H.,Yasukawa, Y.,Yahara, T.,Nishimoto, T.,Kamitani, M.,Fukunaga, T.,Ochiai, N.,Kumasaka-Abe, T.,Hitaka, K.,Gunji, E.,Ohara, H.,Takeda, T.,Kojima, N.,Asami, T.; Discovery of TP0628103: A Selective MMP-7 Inhibitor Based on the Mitigation of OATP Substrate Recognition through Isoelectric Point Shift Strategy; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)