SYK kinase domain in complex with inhibitor GTC000224

Summary for 4YJQ

DescriptorTyrosine-protein kinase SYK, 3-[1H-indazol-4-yl(2-{[3-(4-methyl-1,3-oxazol-5-yl)phenyl]amino}pyrimidin-4-yl)amino]propan-1-ol (3 entities in total)
Functional Keywordssyk, non-receptor tyrosine kinase, spleen tyrosine kinase, transferase, phosphorylation, transferase-transferase inhibitor complex
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane  P43405
Total number of polymer chains1
Total molecular weight33252.09
Somers, D.O.,Neu, M.,Stuckey, J. (deposition date: 2015-03-03, release date: 2015-09-30)
Primary citation
Liddle, J.,Atkinson, F.L.,Barker, M.D.,Carter, P.S.,Curtis, N.R.,Davis, R.P.,Douault, C.,Dickson, M.C.,Elwes, D.,Garton, N.S.,Gray, M.,Hayhow, T.G.,Hobbs, C.I.,Jones, E.,Leach, S.,Leavens, K.,Lewis, H.D.,McCleary, S.,Neu, M.,Patel, V.K.,Preston, A.G.,Ramirez-Molina, C.,Shipley, T.J.,Skone, P.A.,Smithers, N.,Somers, D.O.,Walker, A.L.,Watson, R.J.,Weingarten, G.G.
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Bioorg. Med. Chem. Lett., 21:6188-6194, 2011
PubMed: 21903390 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2011.07.082
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.19010 0.9% 6.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-12-02