3SMQ
| Crystal structure of protein arginine methyltransferase 3 | 分子名称: | 1-(1,2,3-benzothiadiazol-6-yl)-3-[2-(cyclohex-1-en-1-yl)ethyl]urea, CHLORIDE ION, Protein arginine N-methyltransferase 3, ... | 著者 | Dobrovetsky, E, Dong, A, Walker, J.R, Siarheyeva, A, Senisterra, G, Wasney, G.A, Smil, D, Bolshan, Y, Nguyen, K.T, Allali-Hassani, A, Hajian, T, Poda, G, Bountra, C, Weigelt, J, Edwards, A.M, Al-Awar, R, Brown, P.J, Schapira, M, Arrowsmith, C.H, Vedadi, M, Structural Genomics Consortium (SGC) | 登録日 | 2011-06-28 | 公開日 | 2011-08-31 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | An allosteric inhibitor of protein arginine methyltransferase 3. Structure, 20, 2012
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3B8M
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3J68
| Structural mechanism of the dynein powerstroke (pre-powerstroke state) | 分子名称: | Dynein motor domain | 著者 | Lin, J, Okada, K, Raytchev, M, Smith, M.C, Nicastro, D. | 登録日 | 2013-12-23 | 公開日 | 2014-04-23 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (30 Å) | 主引用文献 | Structural mechanism of the dynein power stroke. Nat.Cell Biol., 16, 2014
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3JVM
| Crystal structure of bromodomain 2 of mouse Brd4 | 分子名称: | 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Bromodomain-containing protein 4 | 著者 | Vollmuth, F, Blankenfeldt, W, Geyer, M. | 登録日 | 2009-09-17 | 公開日 | 2009-10-13 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution J.Biol.Chem., 284, 2009
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3B9L
| Human serum albumin complexed with myristate and AZT | 分子名称: | 3'-azido-3'-deoxythymidine, MYRISTIC ACID, Serum albumin | 著者 | Zhu, L, Yang, F, Chen, L, Meehan, E.J, Huang, M. | 登録日 | 2007-11-05 | 公開日 | 2008-05-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography J.Struct.Biol., 162, 2008
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3JXT
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6Z5N
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3K0C
| Crystal structure of the phosphorylation-site double mutant S431A/T432E of the KaiC circadian clock protein | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, MAGNESIUM ION | 著者 | Pattanayek, R, Egli, M, Pattanayek, S. | 登録日 | 2009-09-24 | 公開日 | 2010-03-31 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structures of KaiC Circadian Clock Mutant Proteins: A New Phosphorylation Site at T426 and Mechanisms of Kinase, ATPase and Phosphatase. Plos One, 4, 2009
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3K3H
| Crystal structure of the PDE9A catalytic domain in complex with (S)-BAY73-6691 | 分子名称: | 1-(2-chlorophenyl)-6-[(2S)-3,3,3-trifluoro-2-methylpropyl]-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | 著者 | Wang, H, Luo, X, Ye, M, Hou, J, Robinson, H, Ke, H. | 登録日 | 2009-10-02 | 公開日 | 2010-02-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis J.Med.Chem., 53, 2010
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3B07
| Crystal structure of octameric pore form of gamma-hemolysin from Staphylococcus aureus | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Gamma-hemolysin component A, Gamma-hemolysin component B | 著者 | Yamashita, K, Kawai, Y, Tanaka, Y, Yao, M, Tanaka, I. | 登録日 | 2011-06-06 | 公開日 | 2011-10-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.495 Å) | 主引用文献 | Crystal structure of the octameric pore of
staphylococcal gamma-hemolysin reveals the beta-barrel
pore formation mechanism by two components Proc.Natl.Acad.Sci.USA, 108, 2011
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3J8F
| Cryo-EM reconstruction of poliovirus-receptor complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein VP1, ... | 著者 | Strauss, M, Filman, D.J, Belnap, D.M, Cheng, N, Noel, R.T, Hogle, J.M. | 登録日 | 2014-10-20 | 公開日 | 2015-02-11 | 最終更新日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Nectin-Like Interactions between Poliovirus and Its Receptor Trigger Conformational Changes Associated with Cell Entry. J.Virol., 89, 2015
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3J95
| Structure of ADP-bound N-ethylmaleimide sensitive factor determined by single particle cryoelectron microscopy | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Vesicle-fusing ATPase | 著者 | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | 登録日 | 2014-12-05 | 公開日 | 2015-01-28 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (7.6 Å) | 主引用文献 | Mechanistic insights into the recycling machine of the SNARE complex. Nature, 518, 2015
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3JBT
| Atomic structure of the Apaf-1 apoptosome | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Apoptotic protease-activating factor 1, Cytochrome c, ... | 著者 | Zhou, M, Li, Y, Hu, Q, Bai, X, Huang, W, Yan, C, Scheres, S.H.W, Shi, Y. | 登録日 | 2015-10-15 | 公開日 | 2015-11-18 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1 Genes Dev., 29, 2015
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3JCA
| Core model of the Mouse Mammary Tumor Virus intasome | 分子名称: | 5'-D(*AP*AP*TP*GP*CP*CP*GP*CP*AP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*CP*TP*G)-3', 5'-D(*CP*AP*GP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*TP*GP*CP*GP*GP*CP*A)-3', Integrase, ... | 著者 | Lyumkis, D.L, Ballandras-Colas, A, Brown, M, Cook, N.J, Dewdney, T.G, Demeler, B, Cherepanov, P, Engelman, A.N. | 登録日 | 2015-11-24 | 公開日 | 2016-02-17 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature, 530, 2016
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2E0O
| Mutant Human Ribonuclease 1 (V52L, D53L, N56L, F59L) | 分子名称: | GLYCEROL, Ribonuclease, SULFATE ION | 著者 | Yamada, H, Tamada, T, Kosaka, M, Kuroki, R. | 登録日 | 2006-10-10 | 公開日 | 2007-08-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | 'Crystal lattice engineering,' an approach to engineer protein crystal contacts by creating intermolecular symmetry: crystallization and structure determination of a mutant human RNase 1 with a hydrophobic interface of leucines Protein Sci., 16, 2007
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6ZXF
| Cryo-EM structure of a late human pre-40S ribosomal subunit - State G | 分子名称: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | 著者 | Ameismeier, M, Zemp, I, van den Heuvel, J, Thoms, M, Berninghausen, O, Kutay, U, Beckmann, R. | 登録日 | 2020-07-29 | 公開日 | 2020-12-02 | 最終更新日 | 2020-12-09 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural basis for the final steps of human 40S ribosome maturation. Nature, 587, 2020
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3JWE
| Crystal structure of human mono-glyceride lipase in complex with SAR629 | 分子名称: | 1-[bis(4-fluorophenyl)methyl]-4-(1H-1,2,4-triazol-1-ylcarbonyl)piperazine, MGLL protein | 著者 | Bertrand, T, Auge, F, Houtmann, J, Rak, A, Vallee, F, Mikol, V, Berne, P.F, Michot, N, Cheuret, D, Hoornaert, C, Mathieu, M. | 登録日 | 2009-09-18 | 公開日 | 2010-01-26 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for human monoglyceride lipase inhibition. J.Mol.Biol., 396, 2010
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3SJX
| X-ray structure of human glutamate carboxypeptidase II (the E424A inactive mutant) in complex with N-acetyl-aspartyl-methionine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Plechanovova, A, Byun, Y, Alquicer, G, Skultetyova, L, Mlcochova, P, Nemcova, A, Kim, H, Navratil, M, Mease, R, Lubkowski, J, Pomper, M, Konvalinka, J, Rulisek, L, Barinka, C. | 登録日 | 2011-06-22 | 公開日 | 2011-10-05 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Novel Substrate-Based Inhibitors of Human Glutamate Carboxypeptidase II with Enhanced Lipophilicity. J.Med.Chem., 54, 2011
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2PHN
| Crystal structure of an amide bond forming F420-gamma glutamyl ligase from Archaeoglobus fulgidus | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, F420-0:gamma-glutamyl ligase, ... | 著者 | Nocek, B, Evdokimova, E, Kudritska, M, Edwards, A, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2007-04-11 | 公開日 | 2007-05-15 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Structure of an Amide Bond Forming F(420):gammagamma-glutamyl Ligase from Archaeoglobus Fulgidus - A Member of a New Family of Non-ribosomal Peptide Synthases. J.Mol.Biol., 372, 2007
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6ZWR
| p38a bound with SR92 | 分子名称: | 1,2-ETHANEDIOL, 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-oxidanylidene-1-(pyridin-4-ylmethylamino)butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14 | 著者 | Schroeder, M, Roehm, S, Knapp, S, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Structural Genomics Consortium (SGC) | 登録日 | 2020-07-28 | 公開日 | 2020-08-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Selective targeting of the alpha C and DFG-out pocket in p38 MAPK. Eur.J.Med.Chem., 208, 2020
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8QE0
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8QE2
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6ZXD
| Cryo-EM structure of a late human pre-40S ribosomal subunit - State F1 | 分子名称: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | 著者 | Ameismeier, M, Zemp, I, van den Heuvel, J, Thoms, M, Berninghausen, O, Kutay, U, Beckmann, R. | 登録日 | 2020-07-29 | 公開日 | 2020-12-02 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis for the final steps of human 40S ribosome maturation. Nature, 587, 2020
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3K6G
| Crystal structure of Rap1 and TRF2 complex | 分子名称: | Telomeric repeat-binding factor 2, Telomeric repeat-binding factor 2-interacting protein 1 | 著者 | Chen, Y, Rai, R, Yang, Y.T, Zheng, H, Chang, S, Lei, M. | 登録日 | 2009-10-08 | 公開日 | 2010-10-13 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat.Struct.Mol.Biol., 18, 2011
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1ULM
| Crystal Structure of Pokeweed Lectin-D2 complexed with tri-N-acetylchitotriose | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, lectin-D2 | 著者 | Hayashida, M, Fujii, T, Ishiguro, M, Hata, Y. | 登録日 | 2003-09-12 | 公開日 | 2003-12-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Similarity between protein-protein and protein-carbohydrate interactions, revealed by two crystal structures of lectins from the roots of pokeweed. J.Mol.Biol., 334, 2003
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