3JWE
Crystal structure of human mono-glyceride lipase in complex with SAR629
Summary for 3JWE
Entry DOI | 10.2210/pdb3jwe/pdb |
Descriptor | MGLL protein, 1-[bis(4-fluorophenyl)methyl]-4-(1H-1,2,4-triazol-1-ylcarbonyl)piperazine (3 entities in total) |
Functional Keywords | alpha-beta hydrolase, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 71735.21 |
Authors | Bertrand, T.,Auge, F.,Houtmann, J.,Rak, A.,Vallee, F.,Mikol, V.,Berne, P.F.,Michot, N.,Cheuret, D.,Hoornaert, C.,Mathieu, M. (deposition date: 2009-09-18, release date: 2010-01-26, Last modification date: 2023-09-06) |
Primary citation | Bertrand, T.,Auge, F.,Houtmann, J.,Rak, A.,Vallee, F.,Mikol, V.,Berne, P.F.,Michot, N.,Cheuret, D.,Hoornaert, C.,Mathieu, M. Structural basis for human monoglyceride lipase inhibition. J.Mol.Biol., 396:663-673, 2010 Cited by PubMed: 19962385DOI: 10.1016/j.jmb.2009.11.060 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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