6SSI
| Structure of the pentameric ligand-gated ion channel ELIC in complex with a PAM nanobody | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, CALCIUM ION, ... | 著者 | Ulens, C, Brams, M, Evans, G.L, Spurny, R, Govaerts, C, Pardon, E, Steyaert, J. | 登録日 | 2019-09-07 | 公開日 | 2020-02-12 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT 3 receptor via a common vestibule site. Elife, 9, 2020
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6SUG
| Crystal structure of transthyretin in complex with 3-deoxytolcapone, a tolcapone analogue | 分子名称: | 3-deoxytolcapone, Transthyretin | 著者 | Loconte, V, Cianci, M, Menozzi, I, Sbravati, D, Sansone, F, Casnati, A, Berni, R. | 登録日 | 2019-09-14 | 公開日 | 2020-08-05 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | 主引用文献 | Interactions of tolcapone analogues as stabilizers of the amyloidogenic protein transthyretin. Bioorg.Chem., 103, 2020
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6SVE
| Protein allostery of the WW domain at atomic resolution: pCdc25C bound structure | 分子名称: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 著者 | Strotz, D, Orts, J, Friedmann, M, Guntert, P, Vogeli, B, Riek, R. | 登録日 | 2019-09-18 | 公開日 | 2020-10-07 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Protein Allostery at Atomic Resolution. Angew.Chem.Int.Ed.Engl., 59, 2020
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1ZFU
| Plectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungus | 分子名称: | Plectasin | 著者 | Mygind, P.H, Fischer, R.L, Schnorr, K, Hansen, M.T, Sonksen, C.P, Ludvigsen, S, Raventos, D, Buskov, S, Christensen, B, De Maria, L, Taboureau, O, Yaver, D, Elvig-Jorgensen, S.G, Sorensen, M.V, Christensen, B.E, Kjaerulf, S, Frimodt-Moller, N, Lehrer, R.I, Zasloff, M, Kristensen, H.H. | 登録日 | 2005-04-20 | 公開日 | 2005-10-18 | 最終更新日 | 2021-10-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus. Nature, 437, 2005
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6SKX
| Structure of Reductive Aminase from Neosartorya fumigata | 分子名称: | Oxidoreductase, putative | 著者 | Sharma, M, Mangas-Sanchez, J, Turner, N.J, Grogan, G. | 登録日 | 2019-08-16 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases. Chem Sci, 11, 2020
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6SKZ
| Structure of the closed conformation of CtTel1 | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1 | 著者 | Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P. | 登録日 | 2019-08-16 | 公開日 | 2019-10-30 | 最終更新日 | 2020-01-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State. Structure, 28, 2020
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6SLW
| Fragment AZ-004 binding at the TAZpS89/14-3-3 sigma interface | 分子名称: | 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, WW domain-containing transcription regulator protein 1 | 著者 | Ottmann, C, Wolter, M, Guillory, X, Leysen, S, Genet, S, Somsen, B, Patel, J, Castaldi, P. | 登録日 | 2019-08-20 | 公開日 | 2020-06-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
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6SLZ
| Crystal structure of human ROR gamma LBD in complex with a (quinolinoxymethyl)benzamide inverse agonist | 分子名称: | (2~{S})-1-[2,4-bis(chloranyl)-3-[[2-methyl-4-(trifluoromethyl)quinolin-8-yl]oxymethyl]phenyl]carbonyl-~{N}-methyl-pyrrolidine-2-carboxamide, Nuclear receptor ROR-gamma | 著者 | Amaudrut, J, Argiriadi, M.A, Barth, M, Breinlinger, E.C, Calderwood, D.J, Cusack, K.P, Kort, M.E, Montalbetti, C, Potin, D, Poupardin, O, Spitzer, L. | 登録日 | 2019-08-21 | 公開日 | 2020-09-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of human ROR gamma LBD in complex with a (quinolinoxymethyl)benzamide inverse agonist To Be Published
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6SM7
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6SNQ
| Crystal structures of human PGM1 isoform 2 | 分子名称: | 6-O-phosphono-alpha-D-glucopyranose, Phosphoglucomutase-1, ZINC ION | 著者 | Backe, P.H, Laerdahl, J.K, Kittelsen, L.S, Dalhus, B, Morkrid, L, Bjoras, M. | 登録日 | 2019-08-27 | 公開日 | 2020-04-08 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the alpha-D-phosphohexomutase superfamily. Sci Rep, 10, 2020
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6SPM
| Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with 4-(trifluoromethyl)benzoic acid | 分子名称: | 4-(trifluoromethyl)benzoic acid, DIMETHYL SULFOXIDE, METHANOL, ... | 著者 | Oebbeke, M, Siefker, C, Heine, A, Klebe, G. | 登録日 | 2019-09-02 | 公開日 | 2020-09-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60, 2021
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6SPU
| Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with 3-aminobenzoic acid | 分子名称: | 3-AMINOBENZOIC ACID, DIMETHYL SULFOXIDE, cAMP-dependent protein kinase catalytic subunit alpha | 著者 | Oebbeke, M, Siefker, C, Heine, A, Klebe, G. | 登録日 | 2019-09-02 | 公開日 | 2020-09-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | 主引用文献 | Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60, 2021
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6SQ1
| Crystal structure of cAMP-dependent Protein Kinase A (CHO PKA) in complex with Aminofasudil | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5-(1,4-diazepan-1-ylsulfonyl)isoquinolin-1-amine, DIMETHYL SULFOXIDE, ... | 著者 | Oebbeke, M, Siefker, C, Heine, A, Klebe, G. | 登録日 | 2019-09-03 | 公開日 | 2020-09-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | A crystallographic study of cAMP-dependent Protein Kinase A in complex with different Fasudil-derivatives To Be Published
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6SJX
| Precursor structure of the self-processing module of iron-regulated FrpC of N. Meningitidis with calcium ions | 分子名称: | CALCIUM ION, Iron-regulated protein FrpC | 著者 | Kuban, V, Macek, P, Hritz, J, Nechvatalova, K, Nedbalcova, K, Faldyna, M, Zidek, L, Bumba, L. | 登録日 | 2019-08-14 | 公開日 | 2020-02-26 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Basis of Ca 2+ -Dependent Self-Processing Activity of Repeat-in-Toxin Proteins. Mbio, 11, 2020
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6SJ5
| Crystal structure of the uL14-RsfS complex from Staphylococcus aureus | 分子名称: | 50S ribosomal protein L14, ACETIC ACID, PHOSPHATE ION, ... | 著者 | Fatkhullin, B, Gabdulkhakov, A, Yusupova, G, Yusupov, M. | 登録日 | 2019-08-12 | 公開日 | 2020-04-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.26686549 Å) | 主引用文献 | Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach. Nat Commun, 11, 2020
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6SJS
| Methyltransferase of the MtgA N227A mutant from Desulfitobacterium hafniense in complex with methyl-tetrahydrofolate | 分子名称: | GLYCEROL, N-[4-({[(6S)-2-AMINO-4-HYDROXY-5-METHYL-5,6,7,8-TETRAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC ACID, SODIUM ION, ... | 著者 | Badmann, T, Groll, M. | 登録日 | 2019-08-13 | 公開日 | 2019-09-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structures in Tetrahydrofolate Methylation in Desulfitobacterial Glycine Betaine Metabolism at Atomic Resolution. Chembiochem, 21, 2020
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6SL1
| Structure of the open conformation of CtTel1 | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1 | 著者 | Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P. | 登録日 | 2019-08-16 | 公開日 | 2019-10-30 | 最終更新日 | 2020-05-13 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State. Structure, 28, 2020
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6SLN
| Structure of the RagAB peptide transporter | 分子名称: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Madej, M, Ranson, N.A, White, J.B.R. | 登録日 | 2019-08-20 | 公開日 | 2020-05-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis. Nat Microbiol, 5, 2020
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6SMZ
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7E4T
| Human TRPC5 apo state structure at 3 angstrom | 分子名称: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, ... | 著者 | Chen, L, Song, K, Wei, M, Guo, W. | 登録日 | 2021-02-15 | 公開日 | 2021-03-31 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife, 10, 2021
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3ZVT
| Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin binding protein | 分子名称: | 2,6 DIMETHOXYBENZAMIDOBORONIC ACID, D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, MAGNESIUM ION, ... | 著者 | Sauvage, E, Zervosen, A, Herman, R, Kerff, F, Rocaboy, M, Charlier, P. | 登録日 | 2011-07-27 | 公開日 | 2012-02-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Unexpected Tricovalent Binding Mode of Boronic Acids within the Active Site of a Penicillin- Binding Protein. J.Am.Chem.Soc., 133, 2011
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7LVY
| Crystal Structure of Tetur04g02350 | 分子名称: | UDP-glycosyltransferase 203A2, URIDINE-5'-DIPHOSPHATE, beta-D-glucopyranose | 著者 | Danehsian, L, Kluza, A, Dermauw, W, Wybouw, N, Van Leeuwen, T, Chruszcz, M. | 登録日 | 2021-02-26 | 公開日 | 2022-03-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal Structure of Tetur04g02350 To Be Published
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6T9A
| Crystal structrue of RSL W31FW76F lectin mutant in complex with L-fucose | 分子名称: | 1,2-ETHANEDIOL, Fucose-binding lectin protein, alpha-L-fucopyranose, ... | 著者 | Houser, J, Kozmon, S, Wimmerova, M. | 登録日 | 2019-10-26 | 公開日 | 2020-04-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The CH-pi Interaction in Protein-Carbohydrate Binding: Bioinformatics and In Vitro Quantification. Chemistry, 26, 2020
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3ZCZ
| Crystal structure of a complex between Actinomadura R39 DD-peptidase and a trifluoroketone inhibitor | 分子名称: | (2R)-2-amino-7-oxo-7-{[(2R,3S)-4,4,4-trifluoro-3-hydroxybutan-2-yl]amino}heptanoic acid, D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, MAGNESIUM ION, ... | 著者 | Sauvage, E, Herman, R, Kerff, F, Rocaboy, M, Charlier, P. | 登録日 | 2012-11-23 | 公開日 | 2013-03-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Inhibition of Dd-Peptidases by a Specific Trifluoroketone: Crystal Structure of a Complex with the Actinomadura R39 Dd-Peptidase. Biochemistry, 52, 2013
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6T9N
| CryoEM structure of human polycystin-2/PKD2 in UDM supplemented with PI(4,5)P2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Wang, Q, Pike, A.C.W, Grieben, M, Baronina, A, Nasrallah, C, Shintre, C, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2019-10-28 | 公開日 | 2019-11-20 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2. Structure, 28, 2020
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