3ZVT

Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin binding protein

Replaces:  2Y5R

Summary for 3ZVT

• Entry DOI: 10.2210/pdb3zvt/pdb
• Related: 1W79 1W8Q 1W8Y 2VGJ 2VGK 2WKE 2XDM 2XK1 2XLN 2Y4A 2Y55 2Y59 3ZVW
• Descriptor: D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, 2,6 DIMETHOXYBENZAMIDOBORONIC ACID, SULFATE ION, ... (4 entities in total)
• Functional Keywords: hydrolase, peptidoglycan, penicillin-binding, tetravalent boron
• Biological source: ACTINOMADURA SP.R39
• Cellular location: Secreted: P39045
• Total number of polymer chains: 4
• Total formula weight: 193178.38

Authors

Sauvage, E.,Zervosen, A.,Herman, R.,Kerff, F.,Rocaboy, M.,Charlier, P. (deposition date: 2011-07-27, release date: 2012-02-29, Last modification date: 2023-12-20)

• Primary citation: Zervosen, A.,Herman, R.,Kerff, F.,Herman, A.,Bouillez, A.,Prati, F.,Pratt, R.F.,Frere, J.M.,Joris, B.,Luxen, A.,Charlier, P.,Sauvage, E.; Unexpected Tricovalent Binding Mode of Boronic Acids within the Active Site of a Penicillin- Binding Protein.; J.Am.Chem.Soc., 133:10839-, 2011; PubMed: 21574608; DOI: 10.1021/JA200696Y

Experimental method

X-RAY DIFFRACTION (3.1 Å)