2WKE

Crystal structure of the Actinomadura R39 DD-peptidase inhibited by 6- beta-iodopenicillanate.

Summary for 2WKE

Entry DOI	10.2210/pdb2wke/pdb
Related	1W79 1W8Q 1W8Y 2VGJ 2VGK 2WIX
Descriptor	D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, (3S)-2,2-dimethyl-3,4-dihydro-2H-1,4-thiazine-3,6-dicarboxylic acid, SULFATE ION, ... (5 entities in total)
Functional Keywords	hydrolase, antibiotic resistance, actinomadura, penicillin binding, iodopenicillanate
Biological source	ACTINOMADURA SP.
Cellular location	Secreted: P39045
Total number of polymer chains	4
Total formula weight	194203.31
Authors	Sauvage, E.,Herman, R.,Kerff, F.,Charlier, P. (deposition date: 2009-06-10, release date: 2009-12-01, Last modification date: 2023-12-13)
Primary citation	Sauvage, E.,Zervosen, A.,Dive, G.,Herman, R.,Amoroso, A.,Joris, B.,Fonze, E.,Pratt, R.F.,Luxen, A.,Charlier, P.,Kerff, F. Structural Basis of the Inhibition of Class a Beta-Lactamases and Penicillin-Binding Proteins by 6-Beta-Iodopenicillanate. J.Am.Chem.Soc., 131:15262-, 2009 Cited by PubMed: 19919161 DOI: 10.1021/JA9051526 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation