2Y59

Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin binding protein

Summary for 2Y59

Entry DOI	10.2210/pdb2y59/pdb
Related	1W79 1W8Q 1W8Y 2VGJ 2VGK 2WKE 2XDM 2XK1 2XLN 2Y4A 2Y55 2Y5O 2Y5R
Descriptor	D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, TRIHYDROXY-[[(2-NITROPHENYL)CARBONYLAMINO]METHYL]BORON, SULFATE ION, ... (5 entities in total)
Functional Keywords	hydrolase-inhibitor complex, peptidoglycan, hydrolase
Biological source	ACTINOMADURA SP. R39
Cellular location	Secreted: P39045
Total number of polymer chains	4
Total formula weight	193666.50
Authors	Sauvage, E.,Zervosen, A.,Herman, R.,Kerff, F.,Rocaboy, M.,Charlier, P. (deposition date: 2011-01-12, release date: 2011-07-27, Last modification date: 2023-12-20)
Primary citation	Zervosen, A.,Herman, R.,Kerff, F.,Herman, A.,Bouillez, A.,Prati, F.,Pratt, R.F.,Frere, J.M.,Joris, B.,Luxen, A.,Charlier, P.,Sauvage, E. Unexpected Tricovalent Binding Mode of Boronic Acids within the Active Site of a Penicillin- Binding Protein. J.Am.Chem.Soc., 133:10839-, 2011 Cited by PubMed: 21574608 DOI: 10.1021/JA200696Y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation