5E1S
| The Crystal structure of INSR Tyrosine Kinase in complex with the Inhibitor BI 885578 | 分子名称: | (5R)-N-(1-{2-[4-(2-methoxyethyl)piperazin-1-yl]ethyl}-1H-pyrazol-3-yl)-5,8-dimethyl-9-phenyl-6,8-dihydro-5H-pyrazolo[3,4-h]quinazolin-2-amine, Insulin receptor | 著者 | Kessler, D, Zahn, S, Sanderson, M, Wolkerstorfer, B. | 登録日 | 2015-09-30 | 公開日 | 2015-10-14 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.264 Å) | 主引用文献 | BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis. Mol.Cancer Ther., 14, 2015
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5UZP
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5V4D
| Crystal Structure of the Protein of Unknown Function of the Conserved Rid Protein Family YyfA from Yersinia pestis | 分子名称: | ACETIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Kim, Y, Chhor, G, Endres, M, Krishnan, A, Babnigg, G, Schneewind, O, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2017-03-09 | 公開日 | 2017-04-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal Structure of the Protein of Unknown Function of the Conserved Rid Protein Family YyfA from Yersinia pestis To Be Published
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3U66
| Crystal structure of T6SS SciP/TssL from Escherichia Coli Enteroaggregative 042 | 分子名称: | GLYCEROL, Putative type VI secretion protein | 著者 | Durand, E, Aschtgen, M.S, Zoued, A, Spinelli, S, Watson, P.J.H, Cambillau, C, Cascales, E. | 登録日 | 2011-10-12 | 公開日 | 2012-03-07 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems. J.Biol.Chem., 287, 2012
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6D3G
| PER-2 class A extended-spectrum beta-lactamase crystal structure in complex with avibactam at 2.4 Angstrom resolution | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, TETRAETHYLENE GLYCOL | 著者 | Power, P, Ruggiero, M, Gutkind, G, Bonomo, R, Klinke, S. | 登録日 | 2018-04-16 | 公開日 | 2019-04-24 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.398 Å) | 主引用文献 | Structural Insights into the Inhibition of the Extended-Spectrum beta-Lactamase PER-2 by Avibactam. Antimicrob.Agents Chemother., 63, 2019
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3TJP
| Crystal Structure of PI3K gamma with N6-(3,4-dimethoxyphenyl)-2-morpholino-[4,5'-bipyrimidine]-2',6-diamine | 分子名称: | N~6~-(3,4-dimethoxyphenyl)-2-(morpholin-4-yl)-4,5'-bipyrimidine-2',6-diamine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | 著者 | Knapp, M.S, Elling, R.A, Ornelas, E. | 登録日 | 2011-08-24 | 公開日 | 2012-08-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The Identification of 5-(2,4-dimorpholinopyrimidin-6-yl)-4-(trifluoromethyl)pyridin-2-amine (NVP-BKM120) as a Potent, Selective and Orally Bioavailable Class I PI3 Kinase Inhibitor for the Treatment of Cancer To be Published
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3U99
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2P09
| Structural Insights into the Evolution of a Non-Biological Protein | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, PENTAETHYLENE GLYCOL, ... | 著者 | Smith, M, Rosenow, M, Wang, M, Allen, J.P, Szostak, J.W, Chaput, J.C. | 登録日 | 2007-02-28 | 公開日 | 2007-06-05 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization. PLoS ONE, 2, 2007
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5UM2
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3TNU
| Heterocomplex of coil 2B domains of human intermediate filament proteins, keratin 5 (KRT5) and keratin 14 (KRT14) | 分子名称: | Keratin, type I cytoskeletal 14, type II cytoskeletal 5 | 著者 | Lee, C.H, Kim, M.S, Leahy, D.J, Coulombe, P.A. | 登録日 | 2011-09-02 | 公開日 | 2012-06-20 | 最終更新日 | 2012-08-01 | 実験手法 | X-RAY DIFFRACTION (3.005 Å) | 主引用文献 | Structural basis for heteromeric assembly and perinuclear organization of keratin filaments. Nat.Struct.Mol.Biol., 19, 2012
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2P1N
| Mechanism of Auxin Perception by the TIR1 Ubiqutin Ligase | 分子名称: | (2,4-DICHLOROPHENOXY)ACETIC ACID, Auxin-responsive protein IAA7, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Tan, X, Calderon-Villalobos, L.I.A, Sharon, M, Robinson, C.V, Estelle, M, Zheng, C, Zheng, N. | 登録日 | 2007-03-06 | 公開日 | 2007-04-10 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Mechanism of auxin perception by the TIR1 ubiquitin ligase Nature, 446, 2007
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2PCH
| Crystal structure of PH0725 from Pyrococcus horikoshii OT3 | 分子名称: | Probable diphthine synthase, S-ADENOSYL-L-HOMOCYSTEINE, SODIUM ION | 著者 | Sugahara, M, Taketa, M, Ono, N, Matsuura, Y, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2007-03-29 | 公開日 | 2007-10-02 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of PH0725 from Pyrococcus horikoshii OT3 To be Published
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5UNC
| The crystal structure of PHOSPHOENOLPYRUVATE PHOSPHOMUTASE from Streptomyces platensis subsp. rosaceus | 分子名称: | FORMIC ACID, L(+)-TARTARIC ACID, PHOSPHOENOLPYRUVATE PHOSPHOMUTASE, ... | 著者 | Tan, K, Hatzos-Skintges, C, Endres, M, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2017-01-30 | 公開日 | 2017-02-22 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | The crystal structure of PHOSPHOENOLPYRUVATE PHOSPHOMUTASE from Streptomyces platensis subsp. rosaceus To Be Published
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6D2C
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2PEH
| Crystal structure of the UHM domain of human SPF45 in complex with SF3b155-ULM5 | 分子名称: | Splicing factor 3B subunit 1, Splicing factor 45 | 著者 | Corsini, L, Basquin, J, Hothorn, M, Sattler, M. | 登録日 | 2007-04-03 | 公開日 | 2007-06-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. Nat.Struct.Mol.Biol., 14, 2007
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6CXD
| Crystal structure of peptidase B from Yersinia pestis CO92 at 2.75 A resolution | 分子名称: | Peptidase B, SULFATE ION | 著者 | Woinska, M, Lipowska, J, Shabalin, I.G, Cymborowski, M, Grimshaw, S, Winsor, J, Shuvalova, L, Satchell, K.J, Joachimiak, A, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2018-04-02 | 公開日 | 2018-04-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural and biochemical analysis of Bacillus anthracis prephenate dehydrogenase reveals an unusual mode of inhibition by tyrosine via the ACT domain. Febs J., 287, 2020
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3TNP
| Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme | 分子名称: | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type II-beta regulatory subunit | 著者 | Zhang, P, Smith-Nguyen, E.V, Keshwani, M.M, Deal, M.S, Kornev, A.P, Taylor, S.S. | 登録日 | 2011-09-01 | 公開日 | 2012-02-01 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure and allostery of the PKA RIIbeta tetrameric holoenzyme Science, 335, 2012
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5ULC
| PLASMODIUM FALCIPARUM BROMODOMAIN-CONTAINING PROTEIN PF10_0328 | 分子名称: | Bromodomain protein 1 | 著者 | Wernimont, A.K, Amaya, M.F, Lam, A, Ali, A, Zhang, A.Z, Kenzina, L, Lin, Y.H, MacKenzie, F, Kozieradzki, I, Cossar, D, Schapira, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Weigelt, J, Hui, R, Walker, J.R, Qiu, W, Brand, V, Structural Genomics Consortium (SGC) | 登録日 | 2017-01-24 | 公開日 | 2017-02-22 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | PLASMODIUM FALCIPARUM BROMODOMAIN-CONTAINING PROTEIN PF10_0328 To be published
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3TPF
| Crystal structure of anabolic ornithine carbamoyltransferase from Campylobacter jejuni subsp. jejuni NCTC 11168 | 分子名称: | DI(HYDROXYETHYL)ETHER, Ornithine carbamoyltransferase | 著者 | Shabalin, I.G, Onopriyenko, O, Grimshaw, S, Porebski, P.J, Grabowski, M, Savchenko, A, Chruszcz, M, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2011-09-07 | 公開日 | 2011-09-21 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure of anabolic ornithine carbamoyltransferase from Campylobacter jejuni at 2.7 A resolution. Acta Crystallogr.,Sect.F, 68, 2012
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6CZZ
| Crystal structure of Arabidopsis thaliana phosphoserine aminotransferase isoform 1 (AtPSAT1) in complex with PLP-phosphoserine geminal diamine intermediate | 分子名称: | PHOSPHOSERINE, PYRIDOXAL-5'-PHOSPHATE, Phosphoserine aminotransferase 1, ... | 著者 | Sekula, B, Ruszkowski, M, Dauter, Z. | 登録日 | 2018-04-09 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural Analysis of Phosphoserine Aminotransferase (Isoform 1) FromArabidopsis thaliana- the Enzyme Involved in the Phosphorylated Pathway of Serine Biosynthesis. Front Plant Sci, 9, 2018
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1KX9
| ANTENNAL CHEMOSENSORY PROTEIN A6 FROM THE MOTH MAMESTRA BRASSICAE | 分子名称: | ACETATE ION, CHEMOSENSORY PROTEIN A6 | 著者 | Lartigue, A, Campanacci, V, Roussel, A, Larsson, A.M, Jones, T.A, Tegoni, M, Cambillau, C. | 登録日 | 2002-01-31 | 公開日 | 2002-12-04 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | X-ray structure and ligand binding study of a moth chemosensory protein J.Biol.Chem., 277, 2002
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1V6J
| peanut lectin-lactose complex crystallized in orthorhombic form at acidic pH | 分子名称: | CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ... | 著者 | Kundhavai Natchiar, S, Arockia Jeyaprakash, A, Ramya, T.N.C, Thomas, C.J, Suguna, K, Surolia, A, Vijayan, M. | 登録日 | 2003-12-01 | 公開日 | 2004-02-10 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural plasticity of peanut lectin: an X-ray analysis involving variation in pH, ligand binding and crystal structure. Acta Crystallogr.,Sect.D, 60, 2004
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6CUC
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5UZQ
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6CCX
| NMR data-driven model of GTPase KRas-GMPPNP:Cmpd2 complex tethered to a nanodisc | 分子名称: | (2R,4S)-4-[(5-bromo-1H-indole-3-carbonyl)amino]-2-[(4-chlorophenyl)methyl]piperidin-1-ium, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, ... | 著者 | Fang, Z, Marshall, C.B, Nishikawa, T, Gossert, A.D, Jansen, J.M, Jahnke, W, Ikura, M. | 登録日 | 2018-02-07 | 公開日 | 2018-09-05 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site. Cell Chem Biol, 25, 2018
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