3TJP

Crystal Structure of PI3K gamma with N6-(3,4-dimethoxyphenyl)-2-morpholino-[4,5'-bipyrimidine]-2',6-diamine

Summary for 3TJP

• Entry DOI: 10.2210/pdb3tjp/pdb
• Related: 3SD5
• Descriptor: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, N~6~-(3,4-dimethoxyphenyl)-2-(morpholin-4-yl)-4,5'-bipyrimidine-2',6-diamine, SULFATE ION, ... (4 entities in total)
• Functional Keywords: multi-domain, lipid kinase cell signaling, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P48736
• Total number of polymer chains: 1
• Total formula weight: 111261.67

Authors

Knapp, M.S.,Elling, R.A.,Ornelas, E. (deposition date: 2011-08-24, release date: 2012-08-29, Last modification date: 2023-09-13)

• Primary citation: Burger, M.T.,Pecchi, S.,Wagman, A.,Ni, Z.-J.,Knapp, M.S.,Hendrickson, T.,Atallah, G.,Pfister, K.,Yanchen, Z.,Bartulis, S.,Frazier, K.,Ng, S.,Smith, A.,Verhagen, J.,Haznedar, J.,Huh, K.,Iwanowicz, E.,Xin, X.,Menezes, D.,Merritt, H.,Lee, I.,Weisman, M.,Kaufman, S.,Crawford, K.,Chin, M.,Bussiere, D.,Shoemaker, K.,Zaror, I.,Maira, M.,Voliva, C.; The Identification of 5-(2,4-dimorpholinopyrimidin-6-yl)-4-(trifluoromethyl)pyridin-2-amine (NVP-BKM120) as a Potent, Selective and Orally Bioavailable Class I PI3 Kinase Inhibitor for the Treatment of Cancer; To be Published,

Experimental method

X-RAY DIFFRACTION (2.7 Å)