7PPB
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5DZK
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![BU of 5dzk by Molmil](/molmil-images/mine/5dzk) | Crystal structure of the active form of the proteolytic complex clpP1 and clpP2 | Descriptor: | ATP-dependent Clp protease proteolytic subunit 1, ATP-dependent Clp protease proteolytic subunit 2, BEZ-LEU-LEU | Authors: | LI, M, Wlodawer, A, Maurizi, M. | Deposit date: | 2015-09-25 | Release date: | 2016-02-17 | Last modified: | 2016-04-13 | Method: | X-RAY DIFFRACTION (3.07 Å) | Cite: | Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis. J.Biol.Chem., 291, 2016
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7PPA
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![BU of 7ppa by Molmil](/molmil-images/mine/7ppa) | High resolution structure of bone morphogenetic protein receptor type II (BMPRII) extracellular domain in complex with BMP10 | Descriptor: | Bone morphogenetic protein 10, Bone morphogenetic protein receptor type-2, GLYCEROL | Authors: | Guo, J, Yu, M, Read, R.J, Li, W. | Deposit date: | 2021-09-13 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun, 13, 2022
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2AMX
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![BU of 2amx by Molmil](/molmil-images/mine/2amx) | Crystal structure of Plasmodium Yoelii Adenosine deaminase (PY02076) | Descriptor: | COBALT (II) ION, UNKNOWN ATOM OR ION, adenosine deaminase | Authors: | Dong, A, Vedadi, M, Wasney, G, Zhao, Y, Lew, J, Alam, Z, Melone, M, Koeieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Amani, M, Structural Genomics Consortium (SGC) | Deposit date: | 2005-08-10 | Release date: | 2005-09-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Mol.Biochem.Parasitol., 151, 2007
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6OZZ
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![BU of 6ozz by Molmil](/molmil-images/mine/6ozz) | N terminally deleted GapR crystal structure from C. crescentus | Descriptor: | UPF0335 protein CC_3319 | Authors: | Tarry, M, Harmel, C, Taylor, J.A, Marczynski, G.T, Schmeing, T.M. | Deposit date: | 2019-05-16 | Release date: | 2019-11-27 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.304 Å) | Cite: | Structures of GapR reveal a central channel which could accommodate B-DNA. Sci Rep, 9, 2019
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5NXL
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![BU of 5nxl by Molmil](/molmil-images/mine/5nxl) | Formylglycine generating enzyme from T. curvata in complex with Ag(I) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, CALCIUM ION, ... | Authors: | Meury, M, Knop, M, Seebeck, F.P. | Deposit date: | 2017-05-10 | Release date: | 2017-06-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Structural Basis for Copper-Oxygen Mediated C-H Bond Activation by the Formylglycine-Generating Enzyme. Angew. Chem. Int. Ed. Engl., 56, 2017
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5FVC
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![BU of 5fvc by Molmil](/molmil-images/mine/5fvc) | Structure of RNA-bound decameric HMPV nucleoprotein | Descriptor: | HMPV NUCLEOPROTEIN, RNA | Authors: | Renner, M, Bertinelli, M, Leyrat, C, Paesen, G.C, Saraiva de Oliveira, L.F, Huiskonen, J.T, Grimes, J.M. | Deposit date: | 2016-02-05 | Release date: | 2016-02-24 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (4.17 Å) | Cite: | Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein. Elife, 5, 2016
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5ZZ0
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![BU of 5zz0 by Molmil](/molmil-images/mine/5zz0) | HUMAN GELSOLIN FROM RESIDUES GLU28 TO ARG161 WITH CALCIUM | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, CALCIUM ION, Gelsolin | Authors: | Sharma, P, Badmalia, M, Yadav, S.P.S, Singh, S. | Deposit date: | 2018-05-29 | Release date: | 2019-06-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.635 Å) | Cite: | Bonsai Gelsolin Survives Heat Induced Denaturation by Forming beta-Amyloids which Leach Out Functional Monomer. Sci Rep, 8, 2018
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5OC0
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![BU of 5oc0 by Molmil](/molmil-images/mine/5oc0) | Structure of E. coli superoxide oxidase | Descriptor: | Cytochrome b561, GLYCEROL, MAGNESIUM ION, ... | Authors: | Lundgren, C.A.K, Sjostrand, D, Biner, O, Bennett, M, von Ballmoos, C, Hogbom, M. | Deposit date: | 2017-06-29 | Release date: | 2018-06-20 | Last modified: | 2018-11-07 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Scavenging of superoxide by a membrane-bound superoxide oxidase. Nat. Chem. Biol., 14, 2018
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3N31
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![BU of 3n31 by Molmil](/molmil-images/mine/3n31) | Crystal Structure of the complex of type I ribosome inactivating protein with fucose at 2.1A resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Ribosome inactivating protein, ... | Authors: | Kushwaha, G.S, Pandey, N, Perbandt, M, Betzel, C, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2010-05-19 | Release date: | 2010-06-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Crystal Structure of the complex of type I ribosome inactivating protein with fucose at 2.1A resolution To be Published
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6HXX
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![BU of 6hxx by Molmil](/molmil-images/mine/6hxx) | Potato virus Y | Descriptor: | Coat protein, RNA (5'-R(P*UP*UP*UP*UP*U)-3') | Authors: | Podobnik, M, Kezar, A, Novacek, J, Polak, M. | Deposit date: | 2018-10-18 | Release date: | 2019-08-07 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for the multitasking nature of the potato virus Y coat protein. Sci Adv, 5, 2019
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7RQQ
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6G7J
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![BU of 6g7j by Molmil](/molmil-images/mine/6g7j) | Retinal isomerization in bacteriorhodopsin revealed by a femtosecond X-ray laser: 457-646 fs state structure | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, Bacteriorhodopsin, ... | Authors: | Nogly, P, Weinert, T, James, D, Cabajo, S, Ozerov, D, Furrer, A, Gashi, D, Borin, V, Skopintsev, P, Jaeger, K, Nass, K, Bath, P, Bosman, R, Koglin, J, Seaberg, M, Lane, T, Kekilli, D, Bruenle, S, Tanaka, T, Wu, W, Milne, C, White, T, Barty, A, Weierstall, U, Panneels, V, Nango, E, Iwata, S, Hunter, M, Schapiro, I, Schertler, G, Neutze, R, Standfuss, J. | Deposit date: | 2018-04-06 | Release date: | 2018-06-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser. Science, 361, 2018
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7RQP
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![BU of 7rqp by Molmil](/molmil-images/mine/7rqp) | Structure of PfCSP NPNV binding antibody L9 | Descriptor: | L9 Heavy Chain, L9 Kappa Chain | Authors: | Hurlburt, N.K, Pancera, M. | Deposit date: | 2021-08-06 | Release date: | 2022-03-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria. Cell Rep, 38, 2022
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7RQR
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6G9P
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![BU of 6g9p by Molmil](/molmil-images/mine/6g9p) | Structural basis for the inhibition of E. coli PBP2 | Descriptor: | Peptidoglycan D,D-transpeptidase MrdA | Authors: | Ruff, M, Levy, N. | Deposit date: | 2018-04-11 | Release date: | 2019-05-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design. J.Med.Chem., 62, 2019
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5FDL
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![BU of 5fdl by Molmil](/molmil-images/mine/5fdl) | Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with IDX899 | Descriptor: | P51 Reverse transcriptase, P66 Reverse transcriptase, methyl (R)-(2-carbamoyl-5-chloro-1H-indol-3-yl)[3-(2-cyanoethyl)-5-methylphenyl]phosphinate | Authors: | Dousson, C.B, Alexandre, F.-R, Convard, T, Fisher, M, Lamers, M.B.A.C, Leonard, P.M. | Deposit date: | 2015-12-16 | Release date: | 2016-02-17 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor. J.Med.Chem., 59, 2016
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8EIR
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![BU of 8eir by Molmil](/molmil-images/mine/8eir) | SARS-CoV-2 polyprotein substrate regulates the stepwise Mpro cleavage reaction | Descriptor: | 3C-like proteinase nsp5, nsp7-nsp10 of Replicase polyprotein 1a | Authors: | Narwal, M, Edwards, T, Armache, J.P, Murakami, K.S. | Deposit date: | 2022-09-15 | Release date: | 2023-04-26 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.49 Å) | Cite: | SARS-CoV-2 polyprotein substrate regulates the stepwise M pro cleavage reaction. J.Biol.Chem., 299, 2023
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6G87
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![BU of 6g87 by Molmil](/molmil-images/mine/6g87) | Flavonoid-responsive Regulator FrrA | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, TetR/AcrR family transcriptional regulator | Authors: | Werner, N, Hoppen, J, Palm, G, Werten, S, Goettfert, M, Hinrichs, W. | Deposit date: | 2018-04-07 | Release date: | 2019-04-24 | Last modified: | 2021-08-18 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | The induction mechanism of the flavonoid-responsive regulator FrrA. Febs J., 2021
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8EKE
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7B12
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![BU of 7b12 by Molmil](/molmil-images/mine/7b12) | HUMAN IMMUNOPROTEASOME 20S PARTICLE IN COMPLEX WITH [2-(3-ethylphenyl)-1-[(2S)-3-phenyl-2-[(pyrazin-2-yl)formamido]propanamido]ethyl]boronic acid | Descriptor: | ((R)-2-(3-ethylphenyl)-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)ethyl)boronic acid, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ... | Authors: | Musil, D, Klein, M, Crosignani, S. | Deposit date: | 2020-11-23 | Release date: | 2021-12-01 | Last modified: | 2023-06-14 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 ( beta 5i). J.Med.Chem., 64, 2021
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5MX2
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![BU of 5mx2 by Molmil](/molmil-images/mine/5mx2) | Photosystem II depleted of the Mn4CaO5 cluster at 2.55 A resolution | Descriptor: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | Authors: | Zhang, M, Bommer, M, Chatterjee, R, Hussain, R, Kern, J, Yano, J, Dau, H, Dobbek, H, Zouni, A. | Deposit date: | 2017-01-20 | Release date: | 2017-08-02 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.197 Å) | Cite: | Structural insights into the light-driven auto-assembly process of the water-oxidizing Mn4CaO5-cluster in photosystem II. Elife, 6, 2017
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7R53
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![BU of 7r53 by Molmil](/molmil-images/mine/7r53) | Crystal structure of human TLR8 in complex with Compound 15 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-cyclopropyl-6-(2,6-dimethylpyridin-4-yl)-~{N}-[(3~{R},4~{R})-3-fluoranylpiperidin-4-yl]-1~{H}-indazol-3-amine, Toll-like receptor 8, ... | Authors: | Faller, M, Zink, F. | Deposit date: | 2022-02-10 | Release date: | 2022-03-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.121 Å) | Cite: | Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist. Acs Med.Chem.Lett., 13, 2022
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7R52
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![BU of 7r52 by Molmil](/molmil-images/mine/7r52) | Crystal structure of human TLR8 in complex with Compound 2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-methoxy-6-pyridin-4-yl-1~{H}-indole, Toll-like receptor 8, ... | Authors: | Faller, M, Zink, F. | Deposit date: | 2022-02-10 | Release date: | 2022-03-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.943 Å) | Cite: | Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist. Acs Med.Chem.Lett., 13, 2022
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5FX6
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![BU of 5fx6 by Molmil](/molmil-images/mine/5fx6) | Novel inhibitors of human rhinovirus 3C protease | Descriptor: | RHINOVIRUS 3C PROTEASE, ethyl (4R)-4-[[(2S,4S)-1-[(2S)-3-methyl-2-[(5-methyl-1,2-oxazol-3-yl)carbonylamino]butanoyl]-4-phenyl-pyrrolidin-2-yl]carbonylamino]-5-[(3S)-2-oxidanylidenepyrrolidin-3-yl]pentanoate | Authors: | Kawatkar, S, Ek, M, Hoesch, V, Gagnon, M, Nilsson, E, Lister, T, Olsson, L, Patel, J, Yu, Q. | Deposit date: | 2016-02-24 | Release date: | 2016-06-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Design and Structure-Activity Relationships of Novel Inhibitors of Human Rhinovirus 3C Protease. Bioorg.Med.Chem.Lett., 26, 2016
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