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PDB: 65 件
6CDY
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BU of 6cdy by Molmil
Crystal structure of TEAD complexed with its inhibitor
分子名称: 2-[(4H-1,2,4-triazol-3-yl)sulfanyl]-N-{4-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]phenyl}acetamide, Transcriptional enhancer factor TEF-4
著者LIU, S, HAN, X, LUO, X.
登録日2018-02-09
公開日2020-07-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription.
Cell Stem Cell, 26, 2020
6AR0
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BU of 6ar0 by Molmil
Structure of human SLMAP FHA domain
分子名称: Sarcolemmal membrane-associated protein
著者Ni, L, Luo, X.
登録日2017-08-21
公開日2018-07-04
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.08 Å)
主引用文献SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.
Elife, 6, 2017
6AR2
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BU of 6ar2 by Molmil
Structure of human SLMAP FHA domain in complex with pMST2
分子名称: ASP-GLY-TPO-MET-LYS-ARG, Sarcolemmal membrane-associated protein
著者Osinski, A, Ni, L, Luo, X.
登録日2017-08-21
公開日2018-07-04
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.
Elife, 6, 2017
9CUO
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BU of 9cuo by Molmil
Crystal structure of CRBN with compound 3
分子名称: (3S)-3-(3-methyl-2-oxo-2,3-dihydro-1H-1,3-benzimidazol-1-yl)piperidine-2,6-dione, 1,2-ETHANEDIOL, Protein cereblon, ...
著者Zheng, X, Ji, N, Campbell, V, Slavin, A, Zhu, X, Chen, D, Rong, H, Enerson, B, Mayo, M, Sharma, K, Browne, C.M, Klaus, C.R, Li, H, Massa, G, McDonald, A.A, Shi, Y, Sintchak, M, Skouras, S, Walther, D.M, Yuan, K, Zhang, Y, Kelleher, J, Guang, L, Luo, X, Mainolfi, N, Weiss, M.M.
登録日2024-07-26
公開日2024-08-28
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases.
J.Med.Chem., 2024
3K3E
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BU of 3k3e by Molmil
Crystal structure of the PDE9A catalytic domain in complex with (R)-BAY73-6691
分子名称: 1-(2-chlorophenyl)-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ...
著者Wang, H, Luo, X, Ye, M, Hou, J, Robinson, H, Ke, H.
登録日2009-10-02
公開日2010-02-16
最終更新日2013-11-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis
J.Med.Chem., 53, 2010
3K3H
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BU of 3k3h by Molmil
Crystal structure of the PDE9A catalytic domain in complex with (S)-BAY73-6691
分子名称: 1-(2-chlorophenyl)-6-[(2S)-3,3,3-trifluoro-2-methylpropyl]-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ...
著者Wang, H, Luo, X, Ye, M, Hou, J, Robinson, H, Ke, H.
登録日2009-10-02
公開日2010-02-16
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis
J.Med.Chem., 53, 2010
6LO2
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BU of 6lo2 by Molmil
Crystal structure of EED in complex with EZH2 peptide and compound 11#
分子名称: 8-[4-[(dimethylamino)methyl]phenyl]-N-[(2-methoxyphenyl)methyl]-[1,2,4]triazolo[4,3-a]pyridin-5-amine, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED
著者Zhao, K, Zhao, M, Luo, X, Zhang, H, Chen, Z.
登録日2020-01-02
公開日2021-07-07
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Structure of EED in complex with EZH2 peptide and cmpd20
To Be Published
3GMH
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BU of 3gmh by Molmil
Crystal Structure of the Mad2 Dimer
分子名称: Mitotic spindle assembly checkpoint protein MAD2A, SULFATE ION
著者Ozkan, E, Luo, X, Machius, M, Yu, H, Deisenhofer, J.
登録日2009-03-13
公開日2010-11-17
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (3.95 Å)
主引用文献Structure of an intermediate conformer of the spindle checkpoint protein Mad2.
Proc.Natl.Acad.Sci.USA, 112, 2015
6OCG
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BU of 6ocg by Molmil
Crystal structure of VASH1-SVBP complex bound with EpoY
分子名称: CHLORIDE ION, GLYCEROL, N-[(3R)-4-ethoxy-3-hydroxy-4-oxobutanoyl]-L-tyrosine, ...
著者Li, F, Luo, X, Yu, H.
登録日2019-03-23
公開日2019-06-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.833 Å)
主引用文献Structural basis of tubulin detyrosination by vasohibins.
Nat.Struct.Mol.Biol., 26, 2019
6OCF
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BU of 6ocf by Molmil
The crystal structure of VASH1-SVBP complex
分子名称: CHLORIDE ION, GLYCEROL, Small vasohibin-binding protein, ...
著者Li, F, Luo, X, Yu, H.
登録日2019-03-23
公開日2019-06-26
最終更新日2019-12-18
実験手法X-RAY DIFFRACTION (2.102 Å)
主引用文献Structural basis of tubulin detyrosination by vasohibins.
Nat.Struct.Mol.Biol., 26, 2019
2QYF
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BU of 2qyf by Molmil
Crystal structure of the Mad2/p31(comet)/Mad2-binding peptide ternary complex
分子名称: MAD2L1-binding protein, Mitotic spindle assembly checkpoint protein MAD2A, peptide
著者Tomchick, D.R, Luo, X.
登録日2007-08-14
公開日2008-01-29
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献p31comet blocks Mad2 activation through structural mimicry.
Cell(Cambridge,Mass.), 131, 2007
2IW5
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BU of 2iw5 by Molmil
Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase
分子名称: AMMONIUM ION, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Yang, M, Gocke, C.B, Luo, X, Borek, D, Tomchick, D.R, Machius, M, Otwinowski, Z, Yu, H.
登録日2006-06-26
公開日2006-08-09
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献Structural Basis for Corest-Dependent Demethylation of Nucleosomes by the Human Lsd1 Histone Demethylase
Mol.Cell, 23, 2006
2VFX
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BU of 2vfx by Molmil
Structure of the Symmetric Mad2 Dimer
分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, CHLORIDE ION, ...
著者Yang, M, Li, B, Liu, C.-J, Tomchick, D.R, Machius, M, Rizo, J, Yu, H, Luo, X.
登録日2007-11-05
公開日2008-03-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Insights Into MAD2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric MAD2 Dimer.
Plos Biol., 6, 2008
5H25
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BU of 5h25 by Molmil
EED in complex with PRC2 allosteric inhibitor compound 11
分子名称: 5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED
著者Zhao, K, Zhao, M, Luo, X, Zhang, H.
登録日2016-10-14
公開日2017-01-25
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
5H24
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EED in complex with PRC2 allosteric inhibitor compound 8
分子名称: 5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED
著者Zhao, K, Zhao, M, Luo, X, Zhang, H.
登録日2016-10-14
公開日2017-01-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
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