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PDB: 202 件
6LU5
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BU of 6lu5 by Molmil
Crystal structure of BPTF-BRD with ligand DCBPin5 bound
分子名称: 6-(1H-indol-5-yl)-N-methyl-2-methylsulfonyl-pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF
著者Lu, T, Lu, H.B, Wang, J, Lin, H, Lu, W, Luo, C.
登録日2020-01-25
公開日2021-04-28
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.86527729 Å)
主引用文献Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins
To Be Published
6LU6
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BU of 6lu6 by Molmil
Crystal structure of BPTF-BRD with ligand DCBPin5-2 bound
分子名称: 6-[1-[3-(dimethylamino)propyl]indol-5-yl]-2-methylsulfonyl-N-propyl-pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF
著者Lu, T, Lu, H.B, Wang, J, Lin, H, Lu, W, Luo, C.
登録日2020-01-26
公開日2021-04-28
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.970063 Å)
主引用文献Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins
To Be Published
3LNZ
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BU of 3lnz by Molmil
Crystal structure of human MDM2 with a 12-mer peptide inhibitor PMI (N8A mutant)
分子名称: 12-mer peptide inhibitor, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2
著者Pazgier, M, Lu, W.
登録日2010-02-03
公開日2010-03-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions.
J.Mol.Biol., 398, 2010
2FDP
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BU of 2fdp by Molmil
Crystal structure of beta-secretase complexed with an amino-ethylene inhibitor
分子名称: Beta-secretase 1, N1-((2S,3S,5R)-3-AMINO-6-(4-FLUOROPHENYLAMINO)-5-METHYL-6-OXO-1-PHENYLHEXAN-2-YL)-N3,N3-DIPROPYLISOPHTHALAMIDE
著者Yang, W, Lu, W, Lu, Y, Zhong, M, Sun, J, Thomas, A.E, Wilkinson, J.M, Fucini, R.V, Lam, M, Randal, M, Shi, X.P, Jacobs, J.W, McDowell, R.S, Gordon, E.M, Ballinger, M.D.
登録日2005-12-14
公開日2006-01-24
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.
J.Med.Chem., 49, 2006
3GNY
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BU of 3gny by Molmil
Crystal structure of human alpha-defensin 1 (HNP1)
分子名称: CHLORIDE ION, GLYCEROL, Neutrophil defensin 1
著者Pazgier, M, Lu, W.-Y.
登録日2009-03-18
公開日2009-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Through the looking glass, mechanistic insights from enantiomeric human defensins.
J.Biol.Chem., 284, 2009
3LO2
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BU of 3lo2 by Molmil
Crystal structure of human alpha-defensin 1 (Y21A mutant)
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Neutrophil defensin 1, SULFATE ION, ...
著者Pazgier, M, Lu, W.
登録日2010-02-03
公開日2010-03-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO1
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BU of 3lo1 by Molmil
Crystal structure of human alpha-defensin 1 (Y16A mutant)
分子名称: 2-(2-METHOXYETHOXY)ETHANOL, AZIDE ION, Neutrophil defensin 1
著者Pazgier, M, Lu, W.
登録日2010-02-03
公開日2010-03-09
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LOE
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BU of 3loe by Molmil
Crystal structure of human alpha-defensin 1 (F28A mutant)
分子名称: GLYCEROL, Neutrophil defensin 1, SULFATE ION
著者Pazgier, M, Lu, W.
登録日2010-02-03
公開日2010-03-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO4
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BU of 3lo4 by Molmil
Crystal structure of human alpha-defensin 1 (R24A mutant)
分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Neutrophil defensin 1
著者Pazgier, M, Lu, W.
登録日2010-02-03
公開日2010-03-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO6
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BU of 3lo6 by Molmil
Crystal structure of human alpha-defensin 1 (W26Aba mutant)
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Neutrophil defensin 1
著者Pazgier, M, Lu, W.
登録日2010-02-03
公開日2010-03-09
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO9
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BU of 3lo9 by Molmil
Crystal structure of human alpha-defensin 1 (W26Ahp mutant)
分子名称: Neutrophil defensin 1
著者Pazgier, M, Lu, W.
登録日2010-02-03
公開日2010-03-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LVX
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BU of 3lvx by Molmil
Crystal structure of human alpha-defensin 1 (I6A mutant)
分子名称: GLYCEROL, Neutrophil defensin 1, SULFATE ION
著者Pazgier, M, Lu, W.
登録日2010-02-22
公開日2010-03-09
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
2ZJK
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BU of 2zjk by Molmil
Crystal structure of the human BACE1 catalytic domain in complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic acid(3-mercapto-propyl)-amide
分子名称: (2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide, Beta-secretase 1
著者Randal, M, Lam, M.B, Lu, W, Romanowski, M.J.
登録日2008-03-07
公開日2009-01-20
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Fragment-based discovery of novel BACE1 inhibitors using Tethering technology
To be Published
3GO0
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BU of 3go0 by Molmil
Crystal structure of D-enantiomer of human alpha-defensin 1 (D-HNP1)
分子名称: CHLORIDE ION, Neutrophil defensin 1
著者Pazgier, M, Lu, W.-Y.
登録日2009-03-18
公開日2009-07-28
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Through the looking glass, mechanistic insights from enantiomeric human defensins.
J.Biol.Chem., 284, 2009
9B94
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BU of 9b94 by Molmil
Cryo-EM structure of the E396A mutant of human TRPM4 in complex with calcium at 37 degrees Celsius
分子名称: CALCIUM ION, Transient receptor potential cation channel subfamily M member 4
著者Hu, J, Lu, W, Du, J.
登録日2024-04-01
公開日2024-05-22
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B91
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BU of 9b91 by Molmil
Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium and ATP at 37 degrees Celsius
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Transient receptor potential cation channel subfamily M member 4
著者Hu, J, Lu, W, Du, J.
登録日2024-04-01
公開日2024-05-15
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B90
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BU of 9b90 by Molmil
Cryo-EM structure of the human TRPM4 channel in complex with calcium and ATP at 37 degrees Celsius
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Transient receptor potential cation channel subfamily M member 4
著者Hu, J, Lu, W, Du, J.
登録日2024-04-01
公開日2024-05-15
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B93
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BU of 9b93 by Molmil
Cryo-EM structure of the human TRPM4 channel in the presence of EDTA at 37 degrees Celsius
分子名称: Transient receptor potential cation channel subfamily M member 4
著者Hu, J, Lu, W, Du, J.
登録日2024-04-01
公開日2024-05-15
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B8Z
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BU of 9b8z by Molmil
Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium and decavanadate at 37 degrees Celsius
分子名称: CALCIUM ION, DECAVANADATE, Transient receptor potential cation channel subfamily M member 4
著者Hu, J, Lu, W, Du, J.
登録日2024-04-01
公開日2024-05-15
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B8W
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BU of 9b8w by Molmil
Cryo-EM structure of the human TRPM4 in complex with calcium at 37 degrees Celsius
分子名称: CALCIUM ION, Transient receptor potential cation channel subfamily M member 4
著者Hu, J, Lu, W, Du, J.
登録日2024-04-01
公開日2024-05-15
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B92
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BU of 9b92 by Molmil
Cryo-EM structure of the human TRPM4 in complex with calcium at 18 degrees Celsius
分子名称: CALCIUM ION, Transient receptor potential cation channel subfamily M member 4
著者Hu, J, Lu, W, Du, J.
登録日2024-04-01
公開日2024-05-15
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B8X
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BU of 9b8x by Molmil
Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium 37 degrees Celsius
分子名称: CALCIUM ION, Transient receptor potential cation channel subfamily M member 4
著者Hu, J, Lu, W, Du, J.
登録日2024-04-01
公開日2024-05-15
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
9B8Y
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BU of 9b8y by Molmil
Cryo-EM structure of the human TRPM4 channel in complex with calcium and decavanadate at 37 degrees Celsius
分子名称: CALCIUM ION, DECAVANADATE, Transient receptor potential cation channel subfamily M member 4
著者Hu, J, Lu, W, Du, J.
登録日2024-04-01
公開日2024-05-15
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Physiological temperature drives TRPM4 ligand recognition and gating.
Nature, 630, 2024
1ZMH
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BU of 1zmh by Molmil
Crystal structure of human neutrophil peptide 2, HNP-2 (variant Gly16-> D-Ala)
分子名称: GLYCEROL, HEXAETHYLENE GLYCOL, Neutrophil defensin 2, ...
著者Lubkowski, J, Prahl, A, Lu, W.
登録日2005-05-10
公開日2005-08-16
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
J.Biol.Chem., 280, 2005
1ZMI
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BU of 1zmi by Molmil
Crystal structure of human alpha_defensin-2 (variant GLY16->D-ALA), P 32 2 1 space group )
分子名称: GLYCEROL, Neutrophil defensin 2, SULFATE ION
著者Lubkowski, J, Prahl, A, Lu, W.
登録日2005-05-10
公開日2005-08-16
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
J.Biol.Chem., 280, 2005

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