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PDB: 44 件

6XR2
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BU of 6xr2 by Molmil
Computationally designed right-handed alpha/alpha homotrimeric toroid with 3 repeats per subunit
分子名称: dTor_3x57R
著者Hallinan, J.P, Doyle, L, Bradley, P, Stoddard, B.L.
登録日2020-07-10
公開日2021-07-14
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces.
Commun Biol, 4, 2021
6XR1
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BU of 6xr1 by Molmil
Computationally designed right-handed alpha/alpha single-chain toroid with 9 repeats
分子名称: dTor_9x57R
著者Hallinan, J.P, Doyle, L, Bradley, P, Stoddard, B.L.
登録日2020-07-10
公開日2021-07-14
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces.
Commun Biol, 4, 2021
4YIT
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BU of 4yit by Molmil
Crystal Structure of LAGLIDADG Meganuclease I-AabMI Bound to Uncleaved DNA
分子名称: CALCIUM ION, DNA (25-MER), DNA (25MER), ...
著者Hallinan, J.P, Stoddard, B.L.
登録日2015-03-02
公開日2016-03-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.24 Å)
主引用文献Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
4YIS
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BU of 4yis by Molmil
Crystal Structure of LAGLIDADG Meganuclease I-CpaMI Bound to Uncleaved DNA
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DNA (28-MER), ...
著者Hallinan, J.P, Kaiser, B.K, Stoddard, B.L.
登録日2015-03-02
公開日2016-03-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
4Z1Z
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BU of 4z1z by Molmil
Crystal Structure of Meganuclease I-SmaMI Bound to Uncleaveable DNA with a TTCT Central Four
分子名称: CALCIUM ION, DNA (28-MER), GLYCEROL, ...
著者Hallinan, J.P, Stoddard, B.L.
登録日2015-03-27
公開日2016-03-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
4Z20
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BU of 4z20 by Molmil
Crystal Structure of Meganuclease I-SmaMI Bound to Uncleaveable DNA with a TTGT Central Four
分子名称: CALCIUM ION, DNA (26-MER), GLYCEROL, ...
著者Hallinan, J.P, Stoddard, B.L.
登録日2015-03-27
公開日2016-03-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
4YHX
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BU of 4yhx by Molmil
Crystal Structure of LAGLIDADG Meganuclease I-GpeMI Bound to Uncleaved DNA
分子名称: CALCIUM ION, DNA (27-MER), Ribosomal protein 3/homing endonuclease-like fusion protein
著者Hallinan, J.P, Kaiser, B.K, Stoddard, B.L.
登録日2015-02-27
公開日2016-03-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
5ESP
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BU of 5esp by Molmil
Crystal Structure of LAGLIDADG Meganuclease I-PanMI with coordinated Calcium ions
分子名称: CALCIUM ION, DNA (27-MER), GLYCEROL, ...
著者Hallinan, J.P, Stoddard, B.L.
登録日2015-11-16
公開日2016-03-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.995 Å)
主引用文献Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
4YY5
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BU of 4yy5 by Molmil
Computationally designed left-handed alpha/alpha toroid with 3 repeats in space group P43212
分子名称: dTor_3x33L
著者Hallinan, J.P, Bradley, P, Stoddard, B.L.
登録日2015-03-23
公開日2015-12-16
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献Rational design of alpha-helical tandem repeat proteins with closed architectures.
Nature, 528, 2015
4YY2
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BU of 4yy2 by Molmil
Computationally designed left-handed alpha/alpha toroid with 3 repeats in space group P212121
分子名称: SODIUM ION, dTor_3x33L
著者Hallinan, J.P, Bradley, P, Stoddard, B.L.
登録日2015-03-23
公開日2015-12-16
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.854 Å)
主引用文献Rational design of alpha-helical tandem repeat proteins with closed architectures.
Nature, 528, 2015
5THG
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BU of 5thg by Molmil
Engineered variant of I-OnuI meganuclease targeting the HIV CCR5 gene; harbors 43 point mutations relative to wild-type I-OnuI
分子名称: CALCIUM ION, DNA (29-MER), GLYCEROL, ...
著者Hallinan, J.P, Stoddard, B.L.
登録日2016-09-29
公開日2017-05-03
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.106 Å)
主引用文献The structural basis of altered gene specificity resulting from meganuclease and MegaTAL engineering
to be published
5KW2
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BU of 5kw2 by Molmil
The extra-helical binding site of GPR40 and the structural basis for allosteric agonism and incretin stimulation
分子名称: (3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic acid, Free fatty acid receptor 1,Lysozyme,Free fatty acid receptor 1
著者Ho, J.D, Chau, B, Rodgers, L, Lu, F, Wilbur, K.L, Otto, K.A, Chen, Y, Song, M, Riley, J.P, Yang, H.-C, Reynolds, N.A, Kahl, S.D, Lewis, A.P, Groshong, C, Madsen, R.E, Conners, K, Linswala, J.P, Gheyi, T, Saflor, M.D, Lee, M.R, Benach, J, Baker, K.A, Montrose-Rafizadeh, C, Genin, M.J, Miller, A.R, Hamdouchi, C.
登録日2016-07-15
公開日2018-05-02
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献Structural basis for GPR40 allosteric agonism and incretin stimulation.
Nat Commun, 9, 2018
3WTB
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BU of 3wtb by Molmil
Crystal structure of Gox0525
分子名称: Putative oxidoreductase
著者Yuan, Y.A, Lin, J.P.
登録日2014-04-09
公開日2015-04-15
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of Gox0525
To be Published
3WTC
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BU of 3wtc by Molmil
Crystal structure of Gox2036
分子名称: Putative oxidoreductase
著者Yuan, Y.A, Lin, J.P.
登録日2014-04-09
公開日2015-04-15
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of Gox0525
To be Published
1D8B
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BU of 1d8b by Molmil
NMR STRUCTURE OF THE HRDC DOMAIN FROM SACCHAROMYCES CEREVISIAE RECQ HELICASE
分子名称: SGS1 RECQ HELICASE
著者Liu, Z, Macias, M.J, Bottomley, M.J, Stier, G, Linge, J.P, Nilges, M, Bork, P, Sattler, M.
登録日1999-10-21
公開日2000-01-10
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins.
Structure Fold.Des., 7, 1999
1DZ7
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BU of 1dz7 by Molmil
Solution structure of the a-subunit of human chorionic gonadotropin [modeled without carbohydrate residues]
分子名称: CHORIONIC GONADOTROPIN
著者Erbel, P.J.A, Karimi-Nejad, Y, De Beer, T, Boelens, R, Kamerling, J.P, Vliegenthart, J.F.G.
登録日2000-02-18
公開日2000-02-29
最終更新日2024-10-23
実験手法SOLUTION NMR
主引用文献Solution structure of the alpha-subunit of human chorionic gonadotropin.
Eur.J.Biochem., 260, 1999
6PNR
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BU of 6pnr by Molmil
A GH31 family sulfoquinovosidase from E. rectale in complex with aza-sugar inhibitor IFGSQ
分子名称: Alpha-glucosidase, SULFATE ION, [(3~{S},4~{R},5~{R})-4,5-bis(oxidanyl)piperidin-3-yl]methanesulfonic acid
著者Jarva, M.A, Lingford, J.P, John, A, Goddard-Borger, E.D.
登録日2019-07-03
公開日2020-07-08
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A GH31 family sulfoquinovosidase from E. rectale in complex with aza-sugar inhibitor IFGSQ
To Be Published
4WHA
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BU of 4wha by Molmil
Lipoxygenase-1 (soybean) L546A/L754A mutant
分子名称: 1,2-ETHANEDIOL, ACETATE ION, FE (III) ION, ...
著者Scouras, A.D, Carr, C.A.M, Hu, S, Klinman, J.P.
登録日2014-09-21
公開日2014-11-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Extremely elevated room-temperature kinetic isotope effects quantify the critical role of barrier width in enzymatic C-H activation.
J.Am.Chem.Soc., 136, 2014
4WFO
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BU of 4wfo by Molmil
manganese-substituted soybean lipoxygenase-1
分子名称: 1,2-ETHANEDIOL, ACETATE ION, MANGANESE (II) ION, ...
著者Carr, C.A.M, Scouras, A.D, Klinman, J.P.
登録日2014-09-16
公開日2015-09-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.14 Å)
主引用文献Direct detection of active-site geometries in soybean lipoxygenase-1 by ENDOR
To Be Published
4WSL
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BU of 4wsl by Molmil
Crystal structure of designed cPPR-polyC protein
分子名称: Pentatricopeptide repeat protein
著者Coquille, S.C, Filipovska, A, Chia, T.S, Rajappa, L, Lingford, J.P, Razif, M.F.M, Thore, S, Rackham, O.
登録日2014-10-28
公開日2014-12-24
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献An artificial PPR scaffold for programmable RNA recognition.
Nat Commun, 5, 2014
4WN4
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BU of 4wn4 by Molmil
Crystal structure of designed cPPR-polyA protein
分子名称: Pentatricopeptide repeat protein
著者Coquille, S.C, Filipovska, A, Chia, T.S, Rajappa, L, Lingford, J.P, Razif, M.F.M, Thore, S, Rackham, O.
登録日2014-10-10
公開日2014-12-24
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.85 Å)
主引用文献An artificial PPR scaffold for programmable RNA recognition.
Nat Commun, 5, 2014
4PJS
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BU of 4pjs by Molmil
Crystal structure of designed (SeMet)-cPPR-NRE protein
分子名称: CALCIUM ION, Pentatricopeptide repeat protein
著者Coquille, S.C, Filipovska, A, Chia, T.S, Rajappa, L, Lingford, J.P, Razif, M.F.M, Thore, S, Rackham, O.
登録日2014-05-12
公開日2014-12-24
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献An artificial PPR scaffold for programmable RNA recognition.
Nat Commun, 5, 2014
4PJQ
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BU of 4pjq by Molmil
Crystal structure of designed cPPR-polyG protein
分子名称: Pentatricopeptide repeat protein
著者Coquille, S.C, Filipovska, A, Chia, T.S, Rajappa, L, Lingford, J.P, Razif, M.F.M, Thore, S, Rackham, O.
登録日2014-05-12
公開日2014-12-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.353 Å)
主引用文献An artificial PPR scaffold for programmable RNA recognition.
Nat Commun, 5, 2014
4PJR
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BU of 4pjr by Molmil
Crystal structure of designed cPPR-NRE protein
分子名称: MAGNESIUM ION, Pentatricopeptide repeat protein
著者Coquille, S.C, Filipovska, A, Chia, T.S, Rajappa, L, Lingford, J.P, Razif, M.F.M, Thore, S, Rackham, O.
登録日2014-05-12
公開日2014-12-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献An artificial PPR scaffold for programmable RNA recognition.
Nat Commun, 5, 2014
3N9H
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BU of 3n9h by Molmil
Crystal Structural of mutant Y305A in the copper amine oxidase from hansenula polymorpha
分子名称: COPPER (II) ION, Peroxisomal primary amine oxidase
著者Chen, Z, Datta, S, DuBois, J.L, Klinman, J.P, Mathews, F.S.
登録日2010-05-30
公開日2010-08-25
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mutation at a strictly conserved, active site tyrosine in the copper amine oxidase leads to uncontrolled oxygenase activity.
Biochemistry, 49, 2010

 

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