5GKP
 
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5GKC
 | | The crystal structure of the CPS-6 H148A/F122A | | Descriptor: | Endonuclease G, mitochondrial | | Authors: | Lin, J.L, Yuan, H.S. | | Deposit date: | 2016-07-04 | | Release date: | 2016-11-23 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.892 Å) | | Cite: | Crystal structure of endonuclease G in complex with DNA reveals how it nonspecifically degrades DNA as a homodimer.
Nucleic Acids Res., 44, 2016
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4NSQ
 | | Crystal structure of PCAF | | Descriptor: | COENZYME A, Histone acetyltransferase KAT2B | | Authors: | Lin, J.Y, Cai, Y.F. | | Deposit date: | 2013-11-28 | | Release date: | 2014-03-05 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.3108 Å) | | Cite: | Dimeric structure of p300/CBP associated factor.
Bmc Struct.Biol., 14, 2014
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2L2O
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2LL5
 | | Cyclo-TC1 Trp-cage | | Descriptor: | Cyclo-TC1 | | Authors: | Lin, J.C, Scian, M, Andersen, N.H. | | Deposit date: | 2011-10-26 | | Release date: | 2012-07-18 | | Last modified: | 2024-11-20 | | Method: | SOLUTION NMR | | Cite: | Crystal and NMR structures of a Trp-cage mini-protein benchmark for computational fold prediction.
Proc.Natl.Acad.Sci.USA, 109, 2012
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7XXL
 | | RBD in complex with Fab14 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab14 heavy chain, Fab14 light chain, ... | | Authors: | Lin, J.Q, Tan, Y.J.E, Wu, B, Lescar, J. | | Deposit date: | 2022-05-30 | | Release date: | 2022-09-14 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (7.3 Å) | | Cite: | Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth.
Nat Commun, 13, 2022
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4WQF
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G and fusidic acid in the post-translocational state | | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Lin, J, Gagnon, M.G, Steitz, T.A. | | Deposit date: | 2014-10-21 | | Release date: | 2015-01-28 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation.
Cell, 160, 2015
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4WPO
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the pre-translocational state | | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Lin, J, Gagnon, M.G, Steitz, T.A. | | Deposit date: | 2014-10-20 | | Release date: | 2015-01-28 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation.
Cell, 160, 2015
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4WQY
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the post-translocational state (without fusitic acid) | | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Lin, J, Gagnon, M.G, Steitz, T.A. | | Deposit date: | 2014-10-22 | | Release date: | 2015-01-28 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation.
Cell, 160, 2015
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4WQU
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G trapped by the antibiotic dityromycin | | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Lin, J, Gagnon, M.G, Steitz, T.A. | | Deposit date: | 2014-10-22 | | Release date: | 2015-01-28 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation.
Cell, 160, 2015
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8HO5
 | | Falcilysin in complex with MMV665806 | | Descriptor: | (2S)-1-(2,3-dimethyl-1H-indol-1-yl)-3-{[(1S,2S)-2-methylcyclohexyl]amino}propan-2-ol, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Lin, J.Q, Chung, Z, Lescar, J. | | Deposit date: | 2022-12-09 | | Release date: | 2023-12-20 | | Last modified: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (2.003 Å) | | Cite: | Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development.
Cell Chem Biol, 31, 2024
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8HO4
 | | Falcilysin in complex with MMV000848 | | Descriptor: | (2R)-1-(9H-carbazol-9-yl)-3-(cyclopentylamino)propan-2-ol, 1,2-ETHANEDIOL, Falcilysin, ... | | Authors: | Lin, J.Q, Chung, Z, Lescar, J. | | Deposit date: | 2022-12-09 | | Release date: | 2023-12-20 | | Last modified: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development.
Cell Chem Biol, 31, 2024
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1TUM
 | | MUTT PYROPHOSPHOHYDROLASE-METAL-NUCLEOTIDE-METAL COMPLEX, NMR, 16 STRUCTURES | | Descriptor: | COBALT TETRAAMMINE ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, MAGNESIUM ION, ... | | Authors: | Lin, J, Abeygunawardana, C, Frick, D.N, Bessman, M.J, Mildvan, A.S. | | Deposit date: | 1996-12-05 | | Release date: | 1997-05-15 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the quaternary MutT-M2+-AMPCPP-M2+ complex and mechanism of its pyrophosphohydrolase action.
Biochemistry, 36, 1997
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8GPN
 | | Human menin in complex with H3K79Me2 nucleosome | | Descriptor: | DNA (177-MER), Histone H2A type 1, Histone H2B 1.1, ... | | Authors: | Lin, J, Yu, D, Lam, W.H, Dang, S, Zhai, Y, Li, X.D. | | Deposit date: | 2022-08-26 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-01 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Menin "reads" H3K79me2 mark in a nucleosomal context.
Science, 379, 2023
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3J3P
 | | Conformational Shift of a Major Poliovirus Antigen Confirmed by Immuno-Cryogenic Electron Microscopy: 135S Poliovirus and C3-Fab Complex | | Descriptor: | C3 antibody, heavy chain, light chain, ... | | Authors: | Lin, J, Cheng, N, Hogle, J.M, Steven, A.C, Belnap, D.M. | | Deposit date: | 2013-04-10 | | Release date: | 2013-07-03 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (9.1 Å) | | Cite: | Conformational shift of a major poliovirus antigen confirmed by immuno-cryogenic electron microscopy.
J.Immunol., 191, 2013
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3J3O
 | | Conformational Shift of a Major Poliovirus Antigen Confirmed by Immuno-Cryogenic Electron Microscopy: 160S Poliovirus and C3-Fab Complex | | Descriptor: | C3 antibody, heavy chain, light chain, ... | | Authors: | Lin, J, Cheng, N, Hogle, J.M, Steven, A.C, Belnap, D.M. | | Deposit date: | 2013-04-10 | | Release date: | 2013-07-03 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (11.1 Å) | | Cite: | Conformational shift of a major poliovirus antigen confirmed by immuno-cryogenic electron microscopy.
J.Immunol., 191, 2013
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3J67
 | | Structural mechanism of the dynein powerstroke (post-powerstroke state) | | Descriptor: | Dynein motor domain | | Authors: | Lin, J, Okada, K, Raytchev, M, Smith, M.C, Nicastro, D. | | Deposit date: | 2013-12-22 | | Release date: | 2014-04-23 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (34 Å) | | Cite: | Structural mechanism of the dynein power stroke.
Nat.Cell Biol., 16, 2014
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3J68
 | | Structural mechanism of the dynein powerstroke (pre-powerstroke state) | | Descriptor: | Dynein motor domain | | Authors: | Lin, J, Okada, K, Raytchev, M, Smith, M.C, Nicastro, D. | | Deposit date: | 2013-12-23 | | Release date: | 2014-04-23 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (30 Å) | | Cite: | Structural mechanism of the dynein power stroke.
Nat.Cell Biol., 16, 2014
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5E1N
 | | Selenomethionine Ca2+-Calmodulin from Paramecium tetraurelia qFit disorder model | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, Calmodulin | | Authors: | Lin, J, van den Bedem, H, Brunger, A.T, Wilson, M.A. | | Deposit date: | 2015-09-29 | | Release date: | 2015-11-25 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1 Å) | | Cite: | Atomic resolution experimental phase information reveals extensive disorder and bound 2-methyl-2,4-pentanediol in Ca(2+)-calmodulin.
Acta Crystallogr D Struct Biol, 72, 2016
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5E1K
 | | Selenomethionine Ca2+-Calmodulin from Paramecium tetraurelia SAD data | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, Calmodulin | | Authors: | Lin, J, van den Bedem, H, Brunger, A.T, Wilson, M.A. | | Deposit date: | 2015-09-29 | | Release date: | 2015-11-25 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1 Å) | | Cite: | Atomic resolution experimental phase information reveals extensive disorder and bound 2-methyl-2,4-pentanediol in Ca(2+)-calmodulin.
Acta Crystallogr D Struct Biol, 72, 2016
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5E1P
 | | Ca(2+)-Calmodulin from Paramecium tetraurelia qFit disorder model | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, Calmodulin | | Authors: | Lin, J, van den Bedem, H, Brunger, A.T, Wilson, M.A. | | Deposit date: | 2015-09-29 | | Release date: | 2015-11-25 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.01 Å) | | Cite: | Atomic resolution experimental phase information reveals extensive disorder and bound 2-methyl-2,4-pentanediol in Ca(2+)-calmodulin.
Acta Crystallogr D Struct Biol, 72, 2016
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6K4F
 | | SiaC of Pseudomonas aeruginosa | | Descriptor: | DUF1987 domain-containing protein | | Authors: | Lin, J.Q, Lescar, J. | | Deposit date: | 2019-05-23 | | Release date: | 2019-06-26 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.735 Å) | | Cite: | The SiaABC threonine phosphorylation pathway controls biofilm formation in response to carbon availability in Pseudomonas aeruginosa.
Plos One, 15, 2020
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1ZOM
 | | Crystal Structure of the Catalytic Domain of Coagulation Factor XI in complex with a peptidomimetic Inhibitor | | Descriptor: | (S)-2-(3-((R)-1-(4-BROMOPHENYL)ETHYL)UREIDO)-N-((S)-1-((S)-5-GUANIDINO-1-OXO-1-(THIAZOL-2-YL)PENTAN-2-YLAMINO)-3-METHYL-1-OXOBUTAN-2-YL)-5-UREIDOPENTANAMIDE, Coagulation factor XI, SULFATE ION | | Authors: | Lin, J, Deng, H, Jin, L, Pandey, P, Rynkiewicz, M, Bibbins, F, Cantin, S, Quinn, J, Magee, S, Gorga, J. | | Deposit date: | 2005-05-13 | | Release date: | 2006-05-23 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants.
J.Med.Chem., 49, 2006
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6K4E
 | | SiaA-PP2C domain of Pseudomonas aeruginosa | | Descriptor: | MAGNESIUM ION, Putative serine phosphatase | | Authors: | Lin, J.Q, Lescar, J. | | Deposit date: | 2019-05-23 | | Release date: | 2019-06-26 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.094 Å) | | Cite: | The SiaABC threonine phosphorylation pathway controls biofilm formation in response to carbon availability in Pseudomonas aeruginosa.
Plos One, 15, 2020
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1ZPZ
 | | Factor XI catalytic domain complexed with N-((R)-1-(4-bromophenyl)ethyl)urea-Asn-Val-Arg-alpha-ketothiazole | | Descriptor: | Coagulation factor XI, N~2~-({[(1R)-1-(4-BROMOPHENYL)ETHYL]AMINO}CARBONYL)ASPARAGINYL-N~1~-{4-{[AMINO(IMINO)METHYL]AMINO}-1-[2,3-DIHYDRO-1,3-THIAZOL-2-YL(HYDROXY)METHYL]BUTYL}VALINAMIDE, SULFATE ION | | Authors: | Lin, J, Deng, H, Jin, L, Prandey, P, Rynkiewicz, M.J, Bibbins, F, Cantin, S, Quinn, J, Magee, S, Gorga, J. | | Deposit date: | 2005-05-18 | | Release date: | 2006-05-09 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Design, Synthesis and Biological Evaluation of Peptidomimetic FXIa Inhibitors
To be Published
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