8HO4

Falcilysin in complex with MMV000848

Summary for 8HO4

Entry DOI	10.2210/pdb8ho4/pdb
Descriptor	Falcilysin, (2R)-1-(9H-carbazol-9-yl)-3-(cyclopentylamino)propan-2-ol, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	falcilysin, mmv000848, inhibitor, complex, protein binding, hydrolase
Biological source	Plasmodium falciparum 3D7
Total number of polymer chains	1
Total formula weight	135599.39
Authors	Lin, J.Q.,Chung, Z.,Lescar, J. (deposition date: 2022-12-09, release date: 2023-12-20, Last modification date: 2024-07-03)
Primary citation	Wirjanata, G.,Lin, J.,Dziekan, J.M.,El Sahili, A.,Chung, Z.,Tjia, S.,Binte Zulkifli, N.E.,Boentoro, J.,Tham, R.,Jia, L.S.,Go, K.D.,Yu, H.,Partridge, A.,Olsen, D.,Prabhu, N.,Sobota, R.M.,Nordlund, P.,Lescar, J.,Bozdech, Z. Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development. Cell Chem Biol, 31:743-759.e8, 2024 Cited by PubMed: 38593807 DOI: 10.1016/j.chembiol.2024.03.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.96 Å)

Structure validation