6W6W
 
 | | Cryo-EM structure of CST bound to telomeric single-stranded DNA | | Descriptor: | CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... | | Authors: | Lim, C, Barbour, A.T, Zaug, A.J, Goodrich, K.J, McKay, A.E, Wuttke, D.S, Cech, T.R. | | Deposit date: | 2020-03-17 | | Release date: | 2020-06-03 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | The structure of human CST reveals a decameric assembly bound to telomeric DNA.
Science, 368, 2020
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6UG9
 | | Complex of ch28/11 Fab and SSEA-4 (hexagonal form) | | Descriptor: | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)-alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ch28/11 Fab heavy chain, ch28/11 Fab light chain | | Authors: | Soliman, C, Ramsland, P.A. | | Deposit date: | 2019-09-26 | | Release date: | 2019-12-18 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.74 Å) | | Cite: | The terminal sialic acid of stage-specific embryonic antigen-4 has a crucial role in binding to a cancer-targeting antibody.
J.Biol.Chem., 295, 2020
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6BE3
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6BE4
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6BE2
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6UGA
 | | ch28/11 Fab (monoclinic form) | | Descriptor: | ch28/11 Fab heavy chain, ch28/11 Fab light chain, methanesulfonic acid | | Authors: | Soliman, C, Ramsland, P.A. | | Deposit date: | 2019-09-26 | | Release date: | 2019-12-18 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The terminal sialic acid of stage-specific embryonic antigen-4 has a crucial role in binding to a cancer-targeting antibody.
J.Biol.Chem., 295, 2020
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6UG7
 | | Complex of ch28/11 Fab and SSEA-4 (tetragonal form) | | Descriptor: | 1,2-ETHANEDIOL, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)-alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, SULFATE ION, ... | | Authors: | Soliman, C, Ramsland, P.A. | | Deposit date: | 2019-09-26 | | Release date: | 2019-12-18 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | The terminal sialic acid of stage-specific embryonic antigen-4 has a crucial role in binding to a cancer-targeting antibody.
J.Biol.Chem., 295, 2020
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6UG8
 | | Complex of ch28/11 Fab and SSEA-4 (monoclinic form) | | Descriptor: | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)-alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ch28/11 Fab heavy chain, ch28/11 Fab light chain | | Authors: | Soliman, C, Ramsland, P.A. | | Deposit date: | 2019-09-26 | | Release date: | 2019-12-18 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | The terminal sialic acid of stage-specific embryonic antigen-4 has a crucial role in binding to a cancer-targeting antibody.
J.Biol.Chem., 295, 2020
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6X5E
 | | Crystal structure of a Lewis-binding Fab (ch88.2) | | Descriptor: | NICKEL (II) ION, ch88.2 Fab heavy chain, ch88.2 Fab light chain | | Authors: | Soliman, C, Ramsland, P.A. | | Deposit date: | 2020-05-26 | | Release date: | 2020-08-26 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | Molecular and structural basis for Lewis glycan recognition by a cancer-targeting antibody.
Biochem.J., 477, 2020
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8D9D
 | | Human DNA polymerase-alpha/primase elongation complex II bound to primer/template | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*GP*GP*TP*CP*GP*TP*GP*CP*CP*GP*CP*CP*AP*AP*TP*AP*A)-3'), DNA polymerase alpha catalytic subunit, ... | | Authors: | He, Q, Baranovskiy, A, Lim, C, Tahirov, T. | | Deposit date: | 2022-06-09 | | Release date: | 2023-04-19 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.59 Å) | | Cite: | Structures of human primosome elongation complexes.
Nat.Struct.Mol.Biol., 30, 2023
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8D96
 | | Human DNA polymerase alpha/primase elongation complex I bound to primer/template | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*AP*AP*TP*GP*GP*TP*CP*GP*TP*GP*CP*CP*GP*CP*CP*AP*AP*TP*AP*A)-3'), DNA polymerase alpha catalytic subunit, ... | | Authors: | He, Q, Baranovskiy, A, Lim, C, Tahirov, T. | | Deposit date: | 2022-06-09 | | Release date: | 2023-04-19 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Structures of human primosome elongation complexes.
Nat.Struct.Mol.Biol., 30, 2023
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8D0B
 | | Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template | | Descriptor: | CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... | | Authors: | He, Q, Lin, X, Chavez, B.L, Agrawal, S, Lusk, B.L, Lim, C. | | Deposit date: | 2022-05-26 | | Release date: | 2022-06-22 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.43 Å) | | Cite: | Structures of the human CST-Pol alpha-primase complex bound to telomere templates.
Nature, 608, 2022
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8D0K
 | | Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template - PRIM2C advanced PIC | | Descriptor: | CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... | | Authors: | He, Q, Lin, X, Chavez, B.L, Agrawal, S, Lusk, B.L, Lim, C. | | Deposit date: | 2022-05-26 | | Release date: | 2022-06-22 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (4.27 Å) | | Cite: | Structures of the human CST-Pol alpha-primase complex bound to telomere templates.
Nature, 608, 2022
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9C8U
 | | Human PRC2 - RvLEAM (short) (1:6 molar ratio), cross-linked 10 min | | Descriptor: | Isoform 2 of Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ... | | Authors: | Abe, K.M, Li, G, He, Q, Grant, T, Lim, C. | | Deposit date: | 2024-06-13 | | Release date: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Human PRC2 - RvLEAM (short) (1:6 molar ratio), cross-linked 10 min
To Be Published
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9C8V
 | | Human DNA polymerase alpha/primase - CHAPSO (4 mM) | | Descriptor: | DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase large subunit, ... | | Authors: | Abe, K.M, Li, G, He, Q, Grant, T, Lim, C. | | Deposit date: | 2024-06-13 | | Release date: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | Human DNA polymerase alpha/primase - CHAPSO (4 mM)
To Be Published
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8GY0
 | | Agrocybe pediades linalool sunthase (Ap.LS) | | Descriptor: | Terpene synthase | | Authors: | Rehka, T, Sharma, D, Lin, F, Lim, C, Choong, Y.K, Chacko, J, Zhang, C. | | Deposit date: | 2022-09-21 | | Release date: | 2023-04-12 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.988 Å) | | Cite: | Structural Understanding of Fungal Terpene Synthases for the Formation of Linear or Cyclic Terpene Products.
Acs Catalysis, 13, 2023
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2XA8
 | | Crystal structure of the Fab domain of omalizumab at 2.41A | | Descriptor: | OMALIZUMAB HEAVY CHAIN, OMALIZUMAB LIGHT CHAIN | | Authors: | Huang, C.H, Hung, F.H.A, Lim, C, Chang, T.W, Ma, C. | | Deposit date: | 2010-03-30 | | Release date: | 2011-05-11 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.42 Å) | | Cite: | Structural and Physical Basis for Anti-IgE Therapy.
Sci Rep, 5, 2015
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4LKX
 | | Humanized antibody 4B12 Fab complexed with a CemX segment | | Descriptor: | CemX segment, Fab fragment heavy chain, Fab fragment light chain | | Authors: | Chu, H.M, Wright, J, Chan, Y.H, Lin, C.J, Chang, T.W, Lim, C. | | Deposit date: | 2013-07-09 | | Release date: | 2014-01-29 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Two potential therapeutic antibodies bind to a peptide segment of membrane-bound IgE in different conformations.
Nat Commun, 5, 2014
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8DFY
 | | Crystal structure of Human BTN2A1 Ectodomain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Butyrophilin subfamily 2 member A1, ... | | Authors: | Fulford, T.S, Soliman, C, Castle, R.G, Rigau, M, Ruan, Z, Dolezal, O, Seneviratna, R, Brown, H.G, Hanssen, E, Hammet, A, Li, S, Redmond, S.J, Chung, A, Gorman, M.A, Parker, M.W, Patel, O, Peat, T.S, Newman, J, Behren, A, Gherardin, N.A, Godfrey, D.I, Uldrich, A.P. | | Deposit date: | 2022-06-22 | | Release date: | 2023-07-05 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.552 Å) | | Cite: | Vgamma9-Vdelta2 T cells recognize butyrophilin 2A1 and 3A1 heteromers
To Be Published
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8DFX
 | | Crystal structure of Human BTN2A1-BTN3A1 Ectodomain Complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Butyrophilin subfamily 2 member A1, Butyrophilin subfamily 3 member A1 | | Authors: | Fulford, T.S, Soliman, C, Castle, R.G, Rigau, M, Ruan, Z, Dolezal, O, Seneviratna, R, Brown, H.G, Hanssen, E, Hammet, A, Li, S, Redmond, S.J, Chung, A, Gorman, M.A, Parker, M.W, Patel, O, Peat, T.S, Newman, J, Behren, A, Gherardin, N.A, Godfrey, D.I, Uldrich, A.P. | | Deposit date: | 2022-06-22 | | Release date: | 2023-07-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (5.55 Å) | | Cite: | Vgamma9-Vdelta2 T cells recognize butyrophilin 2A1 and 3A1 heteromers
To Be Published
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8DFW
 | | Crystal Structure of Human BTN2A1 in Complex With Vgamma9-Vdelta2 T Cell Receptor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Butyrophilin subfamily 2 member A1, ... | | Authors: | Fulford, T.S, Soliman, C, Castle, R.G, Rigau, M, Ruan, Z, Dolezal, O, Seneviratna, R, Brown, H.G, Hanssen, E, Hammet, A, Li, S, Redmond, S.J, Chung, A, Gorman, M.A, Parker, M.W, Patel, O, Peat, T.S, Newman, J, Behren, A, Gherardin, N.A, Godfrey, D.I, Uldrich, A.P. | | Deposit date: | 2022-06-22 | | Release date: | 2023-07-05 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Vgamma9-Vdelta2 T cells recognize butyrophilin 2A1 and 3A1 heteromers
To Be Published
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5DEJ
 | | Transthyretin natural mutant A19D | | Descriptor: | CALCIUM ION, Transthyretin | | Authors: | Pereira, H.M, Ferreira, P, Andrade, C, Lima, C, Palhano, F, Foguel, D. | | Deposit date: | 2015-08-25 | | Release date: | 2016-08-31 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.37 Å) | | Cite: | Crystal structure of human Transthyretin natural mutant A19D
To Be Published
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1P9P
 | | The Crystal Structure of a M1G37 tRNA Methyltransferase, TrmD | | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, tRNA (Guanine-N(1)-)-methyltransferase | | Authors: | Elkins, P.A, Watts, J.M, Zalacain, M, Van Thiel, A, Vitaszka, P.R, Redlak, M, Andraos-Selim, C, Rastinejad, F, Holmes, W.M. | | Deposit date: | 2003-05-12 | | Release date: | 2004-05-18 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Insights into Catalysis by a Knotted TrmD tRNA Methyltransferase.
J.Mol.Biol., 333, 2003
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2JMS
 | | NMR Structure of En-6 pheromone from the Antarctic Ciliate Euplotes nobilii | | Descriptor: | Pheromone En-6 | | Authors: | Pedrini, B, Placzek, W.J, Koculi, E, Alimenti, C, LaTerza, A, Luporini, P, Wuthrich, K. | | Deposit date: | 2006-11-29 | | Release date: | 2007-09-04 | | Last modified: | 2024-05-08 | | Method: | SOLUTION NMR | | Cite: | Cold-adaptation in Sea-water-borne Signal Proteins: Sequence and NMR Structure of the Pheromone En-6 from the Antarctic Ciliate Euplotes nobilii
J.Mol.Biol., 372, 2007
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2KC6
 | | NMR solution structure of the pheromone En-1 of Euplotes nobilii at -1.5 C | | Descriptor: | Mating pheromone En-1 | | Authors: | Pedrini, B, Alimenti, C, Vallesi, A, Luporini, P, Wuthrich, K. | | Deposit date: | 2008-12-17 | | Release date: | 2009-08-04 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | Molecular cold-adaptation: Comparative analysis of two homologous families of psychrophilic and mesophilic signal proteins of the protozoan ciliate, Euplotes.
Iubmb Life, 61, 2009
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