6W6W

Cryo-EM structure of CST bound to telomeric single-stranded DNA

Summary for 6W6W

• Entry DOI: 10.2210/pdb6w6w/pdb
• EMDB information: 21567
• Descriptor: CST complex subunit CTC1, DNA (5'-D(P*TP*AP*GP*G)-3'), CST complex subunit STN1, ... (5 entities in total)
• Functional Keywords: telomere homeostasis, telomere packaging, telomerase terminator, dna replication, double-stranded breaks repair, single-stranded dna-binding proteins, higher-order protein assembly, dna-induced oligomeriization, structural protein, structural protein-dna complex, structural protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 335075.66

Authors

Lim, C.,Barbour, A.T.,Zaug, A.J.,Goodrich, K.J.,McKay, A.E.,Wuttke, D.S.,Cech, T.R. (deposition date: 2020-03-17, release date: 2020-06-03, Last modification date: 2020-06-17)

• Primary citation: Lim, C.J.,Barbour, A.T.,Zaug, A.J.,Goodrich, K.J.,McKay, A.E.,Wuttke, D.S.,Cech, T.R.; The structure of human CST reveals a decameric assembly bound to telomeric DNA.; Science, 368:1081-1085, 2020; PubMed: 32499435; DOI: 10.1126/science.aaz9649

Experimental method

ELECTRON MICROSCOPY (3 Å)