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6W6W

Cryo-EM structure of CST bound to telomeric single-stranded DNA

Functional Information from GO Data
ChainGOidnamespacecontents
A0000723biological_processtelomere maintenance
A0000781cellular_componentchromosome, telomeric region
A0003677molecular_functionDNA binding
A0003697molecular_functionsingle-stranded DNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005829cellular_componentcytosol
A0006974biological_processDNA damage response
A0010389biological_processregulation of G2/M transition of mitotic cell cycle
A0010833biological_processtelomere maintenance via telomere lengthening
A0016233biological_processtelomere capping
A0032211biological_processnegative regulation of telomere maintenance via telomerase
A0035264biological_processmulticellular organism growth
A0042162molecular_functiontelomeric DNA binding
A0045740biological_processpositive regulation of DNA replication
A0048146biological_processpositive regulation of fibroblast proliferation
A0048536biological_processspleen development
A0048538biological_processthymus development
A0048539biological_processbone marrow development
A0051276biological_processchromosome organization
A0071425biological_processhematopoietic stem cell proliferation
A0090399biological_processreplicative senescence
A0098505molecular_functionG-rich strand telomeric DNA binding
A1990879cellular_componentCST complex
B0000723biological_processtelomere maintenance
B0000781cellular_componentchromosome, telomeric region
B0003677molecular_functionDNA binding
B0003697molecular_functionsingle-stranded DNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005829cellular_componentcytosol
B0006974biological_processDNA damage response
B0010389biological_processregulation of G2/M transition of mitotic cell cycle
B0010833biological_processtelomere maintenance via telomere lengthening
B0016233biological_processtelomere capping
B0032211biological_processnegative regulation of telomere maintenance via telomerase
B0035264biological_processmulticellular organism growth
B0042162molecular_functiontelomeric DNA binding
B0045740biological_processpositive regulation of DNA replication
B0048146biological_processpositive regulation of fibroblast proliferation
B0048536biological_processspleen development
B0048538biological_processthymus development
B0048539biological_processbone marrow development
B0051276biological_processchromosome organization
B0071425biological_processhematopoietic stem cell proliferation
B0090399biological_processreplicative senescence
B0098505molecular_functionG-rich strand telomeric DNA binding
B1990879cellular_componentCST complex
C0000723biological_processtelomere maintenance
C0000781cellular_componentchromosome, telomeric region
C0001650cellular_componentfibrillar center
C0003676molecular_functionnucleic acid binding
C0003677molecular_functionDNA binding
C0003697molecular_functionsingle-stranded DNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0010833biological_processtelomere maintenance via telomere lengthening
C0016233biological_processtelomere capping
C0032211biological_processnegative regulation of telomere maintenance via telomerase
C0042162molecular_functiontelomeric DNA binding
C0043047molecular_functionsingle-stranded telomeric DNA binding
C0043229cellular_componentintracellular organelle
C0043231cellular_componentintracellular membrane-bounded organelle
C0045111cellular_componentintermediate filament cytoskeleton
C0045740biological_processpositive regulation of DNA replication
C1990879cellular_componentCST complex
D0000781cellular_componentchromosome, telomeric region
D0003677molecular_functionDNA binding
D0003697molecular_functionsingle-stranded DNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005694cellular_componentchromosome
D0010521molecular_functiontelomerase inhibitor activity
D0016233biological_processtelomere capping
D0032211biological_processnegative regulation of telomere maintenance via telomerase
D0042162molecular_functiontelomeric DNA binding
D1990879cellular_componentCST complex
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 1301
ChainResidue
ACYS1043
ACYS1046
ACYS1055
ACYS1062

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues98
DetailsDNA_BIND: OB
ChainResidueDetails
CVAL57-VAL155

221371

PDB entries from 2024-06-19

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