6W6W

Cryo-EM structure of CST bound to telomeric single-stranded DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000723	biological_process	telomere maintenance
A	0000781	cellular_component	chromosome, telomeric region
A	0003677	molecular_function	DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0010833	biological_process	telomere maintenance via telomere lengthening
A	0016233	biological_process	telomere capping
A	0032211	biological_process	negative regulation of telomere maintenance via telomerase
A	0042162	molecular_function	telomeric DNA binding
A	0045740	biological_process	positive regulation of DNA replication
A	0098505	molecular_function	G-rich strand telomeric DNA binding
A	1990879	cellular_component	CST complex
B	0000723	biological_process	telomere maintenance
B	0000781	cellular_component	chromosome, telomeric region
B	0003677	molecular_function	DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0010833	biological_process	telomere maintenance via telomere lengthening
B	0016233	biological_process	telomere capping
B	0032211	biological_process	negative regulation of telomere maintenance via telomerase
B	0042162	molecular_function	telomeric DNA binding
B	0045740	biological_process	positive regulation of DNA replication
B	0098505	molecular_function	G-rich strand telomeric DNA binding
B	1990879	cellular_component	CST complex
C	0000723	biological_process	telomere maintenance
C	0000781	cellular_component	chromosome, telomeric region
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0003697	molecular_function	single-stranded DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0010833	biological_process	telomere maintenance via telomere lengthening
C	0016233	biological_process	telomere capping
C	0032211	biological_process	negative regulation of telomere maintenance via telomerase
C	0042162	molecular_function	telomeric DNA binding
C	0043047	molecular_function	single-stranded telomeric DNA binding
C	0045740	biological_process	positive regulation of DNA replication
C	0051052	biological_process	regulation of DNA metabolic process
C	1990879	cellular_component	CST complex
D	0000781	cellular_component	chromosome, telomeric region
D	0003677	molecular_function	DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0010521	molecular_function	telomerase inhibitor activity
D	0016233	biological_process	telomere capping
D	0032211	biological_process	negative regulation of telomere maintenance via telomerase
D	0042162	molecular_function	telomeric DNA binding
D	1990879	cellular_component	CST complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1301

Chain	Residue
A	CYS1043
A	CYS1046
A	CYS1055
A	CYS1062

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Region: {"description":"Winged helix-turn-helix (wHTH) 2"}

Chain

Residue

Details

---