6UG7

Complex of ch28/11 Fab and SSEA-4 (tetragonal form)

Summary for 6UG7

• Entry DOI: 10.2210/pdb6ug7/pdb
• Descriptor: ch28/11 Fab light chain, ch28/11 Fab heavy chain, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)-alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: immunoglobulin, chimeric antibody, antigen binding fragment, ssea-4, complex, immune system
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 2
• Total formula weight: 48039.21

Authors

Soliman, C.,Ramsland, P.A. (deposition date: 2019-09-26, release date: 2019-12-18, Last modification date: 2023-10-11)

• Primary citation: Soliman, C.,Chua, J.X.,Vankemmelbeke, M.,McIntosh, R.S.,Guy, A.J.,Spendlove, I.,Durrant, L.G.,Ramsland, P.A.; The terminal sialic acid of stage-specific embryonic antigen-4 has a crucial role in binding to a cancer-targeting antibody.; J.Biol.Chem., 295:1009-1020, 2020; PubMed: 31831622; DOI: 10.1074/jbc.RA119.011518

Experimental method

X-RAY DIFFRACTION (1.52 Å)