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PDB: 67 件
6AOM
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BU of 6aom by Molmil
Structure of molecular chaperone Grp94 bound to selective inhibitor methyl 2-[2-(2-benzylphenyl)ethyl]-3-chloro-4,6-dihydroxybenzoate
分子名称: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, DI(HYDROXYETHYL)ETHER, Endoplasmin, ...
著者Lieberman, R.L, Huard, D.J.E.
登録日2017-08-16
公開日2017-10-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献Second Generation Grp94-Selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer.
Chemistry, 23, 2017
3NN8
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BU of 3nn8 by Molmil
Crystal structure of engineered antibody fragment based on 3D5
分子名称: Engineered scFv
著者Lieberman, R.L, Maynard, J.A, Drury, J.E, Pai, J, Culver, J.A.
登録日2010-06-23
公開日2011-06-29
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Peptide-binding single chain Antibody fragment (SCFV) chaperones for protein co-crystallization
To be Published
5IN9
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BU of 5in9 by Molmil
Crystal structure of Grp94 bound to methyl 3-chloro-2-(2-(1-((5-chlorofuran-2-yl)methyl)-1H-imidazol-2-yl)ethyl)-4,6-dihydroxybenzoate, an inhibitor based on the BnIm and Radamide scaffolds.
分子名称: Endoplasmin, GLYCEROL, TRIETHYLENE GLYCOL, ...
著者Lieberman, R.L, Huard, D.J.E, Kizziah, J.L.
登録日2016-03-07
公開日2016-05-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold.
J.Med.Chem., 59, 2016
6VIO
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BU of 6vio by Molmil
Crystal structure of eYFP His148Ser
分子名称: Green fluorescent protein GFP
著者Lieberman, R.L, Hill, S.E, Patterson-Orazem, A.C.
登録日2020-01-13
公開日2021-01-13
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Optically Modulated and Optically Activated Delayed Fluorescent Proteins through Dark State Engineering
J.Phys.Chem.B, 125, 2021
1YEW
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BU of 1yew by Molmil
Crystal structure of particulate methane monooxygenase
分子名称: COPPER (II) ION, DINUCLEAR COPPER ION, ZINC ION, ...
著者Lieberman, R.L, Rosenzweig, A.C.
登録日2004-12-28
公開日2005-02-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.801 Å)
主引用文献Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane.
Nature, 434, 2005
6AOL
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BU of 6aol by Molmil
Structure of molecular chaperone Grp94 bound to selective inhibitor methyl 3-chloro-2-(2-{2-[(4-fluorophenyl)methyl]phenyl}ethyl)-4,6-dihydroxybenzoate
分子名称: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Endoplasmin, methyl 3-chloro-2-(2-{2-[(4-fluorophenyl)methyl]phenyl}ethyl)-4,6-dihydroxybenzoate
著者Lieberman, R.L, Huard, D.J.E.
登録日2017-08-16
公開日2017-10-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.764 Å)
主引用文献Second Generation Grp94-Selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer.
Chemistry, 23, 2017
2NT1
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BU of 2nt1 by Molmil
Structure of acid-beta-glucosidase at neutral pH
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glucosylceramidase, PHOSPHATE ION
著者Lieberman, R.L, Petsko, G.A, Ringe, D.
登録日2006-11-06
公開日2006-12-26
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.
Nat.Chem.Biol., 3, 2007
2NSX
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BU of 2nsx by Molmil
Structure of acid-beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, GLYCEROL, ...
著者Lieberman, R.L, Petsko, G.A, Ringe, D.
登録日2006-11-06
公開日2006-12-26
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.
Nat.Chem.Biol., 3, 2007
2NT0
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BU of 2nt0 by Molmil
Acid-beta-glucosidase low pH, glycerol bound
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Glucosylceramidase, ...
著者Lieberman, R.L, Petsko, G.A, Ringe, D.
登録日2006-11-06
公開日2006-12-26
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.
Nat.Chem.Biol., 3, 2007
6NIZ
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BU of 6niz by Molmil
Atomic structure of a fluorescent Ag8 cluster templated by a multistranded DNA scaffold
分子名称: DNA (5'-D(*AP*AP*CP*CP*CP*CP)-3'), SILVER ION
著者Lieberman, R.L, Huard, D.J.E.
登録日2019-01-02
公開日2019-01-16
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (0.93 Å)
主引用文献Atomic Structure of a Fluorescent Ag8Cluster Templated by a Multistranded DNA Scaffold.
J.Am.Chem.Soc., 141, 2019
7SOG
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BU of 7sog by Molmil
Thermostable actophorin
分子名称: Actophorin, NICKEL (II) ION
著者Lieberman, R.L, Quirk, S.
登録日2021-10-30
公開日2022-04-20
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Structure and activity of a thermally stable mutant of Acanthamoeba actophorin.
Acta Crystallogr.,Sect.F, 78, 2022
5VR2
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BU of 5vr2 by Molmil
mouse myocilin leucine zipper C-terminal 7 heptad repeat
分子名称: Myocilin
著者Lieberman, R.L, Hill, S.E.
登録日2017-05-10
公開日2017-11-08
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.922 Å)
主引用文献Structure and Misfolding of the Flexible Tripartite Coiled-Coil Domain of Glaucoma-Associated Myocilin.
Structure, 25, 2017
5TTZ
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BU of 5ttz by Molmil
Crystal structure of Grp94 bound to isoform-selective inhibitor methyl 2-(2-(1-(4-bromobenzyl)-1H-imidazol-2-yl)ethyl)-3-chloro-4,6-dihydroxybenzoate
分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, DI(HYDROXYETHYL)ETHER, Endoplasmin, ...
著者Lieberman, R.L, Huard, D.J.E.
登録日2016-11-04
公開日2018-01-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.707 Å)
主引用文献Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma.
Sci Rep, 7, 2017
3GXP
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BU of 3gxp by Molmil
Crystal structure of acid-alpha-galactosidase A complexed with galactose at pH 4.5
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, ...
著者Lieberman, R.L.
登録日2009-04-02
公開日2009-05-05
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.
Biochemistry, 48, 2009
3GXI
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BU of 3gxi by Molmil
Crystal structure of acid-beta-glucosidase at pH 5.5
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glucosylceramidase, PHOSPHATE ION
著者Lieberman, R.L.
登録日2009-04-02
公開日2009-05-05
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.
Biochemistry, 48, 2009
3GXN
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BU of 3gxn by Molmil
Crystal structure of apo alpha-galactosidase A at pH 4.5
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, SULFATE ION
著者Lieberman, R.L.
登録日2009-04-02
公開日2009-05-05
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.
Biochemistry, 48, 2009
3GXD
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BU of 3gxd by Molmil
Crystal structure of Apo acid-beta-glucosidase pH 4.5
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glucosylceramidase, PHOSPHATE ION
著者Lieberman, R.L.
登録日2009-04-02
公開日2009-05-05
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.
Biochemistry, 48, 2009
3GXF
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BU of 3gxf by Molmil
Crystal structure of acid-beta-glucosidase with isofagomine at neutral pH
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, GLYCEROL, ...
著者Lieberman, R.L.
登録日2009-04-02
公開日2009-05-05
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.
Biochemistry, 48, 2009
3GXT
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BU of 3gxt by Molmil
Crystal structure of alpha-galactosidase A at pH 4.5 complexed with 1-deoxygalactonijirimycin
分子名称: 1-DEOXYNOJIRIMYCIN, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Lieberman, R.L.
登録日2009-04-02
公開日2009-05-26
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.
Biochemistry, 48, 2009
3GXM
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BU of 3gxm by Molmil
Crystal structure of acid-beta-glucosidase at pH 4.5, phosphate crystallization condition
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glucosylceramidase, SULFATE ION
著者Lieberman, R.L.
登録日2009-04-02
公開日2009-05-05
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.
Biochemistry, 48, 2009
6PKE
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BU of 6pke by Molmil
Myocilin OLF mutant N428E/D478S
分子名称: Myocilin
著者Lieberman, R.L, Hill, S.E.
登録日2019-06-29
公開日2019-09-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Calcium-ligand variants of the myocilin olfactomedin propeller selected from invertebrate phyla reveal cross-talk with N-terminal blade and surface helices.
Acta Crystallogr D Struct Biol, 75, 2019
6PKF
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BU of 6pkf by Molmil
Myocilin OLF mutant N428E/D478K
分子名称: GLYCEROL, Myocilin
著者Lieberman, R.L, Hill, S.E.
登録日2019-06-29
公開日2019-09-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.484 Å)
主引用文献Calcium-ligand variants of the myocilin olfactomedin propeller selected from invertebrate phyla reveal cross-talk with N-terminal blade and surface helices.
Acta Crystallogr D Struct Biol, 75, 2019
6PKD
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BU of 6pkd by Molmil
Myocilin OLF mutant N428D/D478H
分子名称: Myocilin, SODIUM ION
著者Lieberman, R.L, Hill, S.E.
登録日2019-06-29
公開日2019-09-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Calcium-ligand variants of the myocilin olfactomedin propeller selected from invertebrate phyla reveal cross-talk with N-terminal blade and surface helices.
Acta Crystallogr D Struct Biol, 75, 2019
7RTX
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BU of 7rtx by Molmil
Actophorin grown in microgravity
分子名称: Actophorin
著者Lieberman, R.L, Quirk, S.
登録日2021-08-16
公開日2021-12-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Improved resolution crystal structure of Acanthamoeba actophorin reveals structural plasticity not induced by microgravity.
Acta Crystallogr.,Sect.F, 77, 2021
1IBY
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BU of 1iby by Molmil
RED COPPER PROTEIN NITROSOCYANIN FROM NITROSOMONAS EUROPAEA
分子名称: COPPER (II) ION, HEXANE-1,6-DIOL, NITROSOCYANIN
著者Lieberman, R.L, Arciero, D.M, Hooper, A.B, Rosenzweig, A.C.
登録日2001-03-29
公開日2001-06-06
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of a novel red copper protein from Nitrosomonas europaea.
Biochemistry, 40, 2001

 

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