5TTZ

Crystal structure of Grp94 bound to isoform-selective inhibitor methyl 2-(2-(1-(4-bromobenzyl)-1H-imidazol-2-yl)ethyl)-3-chloro-4,6-dihydroxybenzoate

Summary for 5TTZ

• Entry DOI: 10.2210/pdb5ttz/pdb
• Descriptor: Endoplasmin, methyl 2-(2-{1-[(4-bromophenyl)methyl]-1H-imidazol-2-yl}ethyl)-3-chloro-4,6-dihydroxybenzoate, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
• Functional Keywords: bnim scaffold, atp binding site, chaperone - inhibitor complex, chaperone / inhibitor
• Biological source: Canis lupus familiaris (Dog)
• Total number of polymer chains: 2
• Total formula weight: 54111.64

Authors

Lieberman, R.L.,Huard, D.J.E. (deposition date: 2016-11-04, release date: 2018-01-10, Last modification date: 2023-10-04)

• Primary citation: Stothert, A.R.,Suntharalingam, A.,Tang, X.,Crowley, V.M.,Mishra, S.J.,Webster, J.M.,Nordhues, B.A.,Huard, D.J.E.,Passaglia, C.L.,Lieberman, R.L.,Blagg, B.S.J.,Blair, L.J.,Koren, J.,Dickey, C.A.; Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma.; Sci Rep, 7:17951-17951, 2017; PubMed: 29263415; DOI: 10.1038/s41598-017-18344-4

Experimental method

X-RAY DIFFRACTION (2.707 Å)