3GXP

Crystal structure of acid-alpha-galactosidase A complexed with galactose at pH 4.5

Summary for 3GXP

• Entry DOI: 10.2210/pdb3gxp/pdb
• Related: 3GXN 3GXT
• Descriptor: Alpha-galactosidase A, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: hydrolase, disease mutation, disulfide bond, glycoprotein, glycosidase, lysosome, rna editing
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 94783.74

Authors

Lieberman, R.L. (deposition date: 2009-04-02, release date: 2009-05-05, Last modification date: 2020-07-29)

• Primary citation: Lieberman, R.L.,D'aquino, J.A.,Ringe, D.,Petsko, G.A.; Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.; Biochemistry, 48:4816-4827, 2009; PubMed: 19374450; DOI: 10.1021/bi9002265

Experimental method

X-RAY DIFFRACTION (2.2 Å)