6NIZ

Atomic structure of a fluorescent Ag8 cluster templated by a multistranded DNA scaffold

Summary for 6NIZ

• Entry DOI: 10.2210/pdb6niz/pdb
• Descriptor: DNA (5'-D(*AP*AP*CP*CP*CP*CP)-3'), SILVER ION (3 entities in total)
• Functional Keywords: dna, silver, emissive cluster, nanocluster
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 4770.78

Authors

Lieberman, R.L.,Huard, D.J.E. (deposition date: 2019-01-02, release date: 2019-01-16, Last modification date: 2024-03-13)

Primary citation

Huard, D.J.E.,Demissie, A.,Kim, D.,Lewis, D.,Dickson, R.M.,Petty, J.T.,Lieberman, R.L.
Atomic Structure of a Fluorescent Ag8Cluster Templated by a Multistranded DNA Scaffold.
J.Am.Chem.Soc., 141:11465-11470, 2019

PubMed Abstract: Multinuclear silver clusters encapsulated by DNA exhibit size-tunable emission spectra and rich photophysics, but their atomic organization is poorly understood. Herein, we describe the structure of one such hybrid chromophore, a green-emitting Ag cluster arranged in a Big Dipper-shape bound to the oligonucleotide AC. Three 3' cytosine metallo-base pairs stabilize a parallel A-form-like duplex with a 5' adenine-rich pocket, which binds a metallic, trapezoidal-shaped Ag moiety via Ag-N bonds to endo- and exocyclic nitrogens of cytosine and adenine. The unique DNA configuration, constrained coordination environment, and templated Ag cluster arrangement highlight the reciprocity between the silvers and DNA in adopting this structure. These first atomic details of a DNA-encapsulated Ag cluster fluorophore illuminate many aspects of biological assembly, nanoscience, and metal cluster photophysics.

PubMed: 30562465
DOI: 10.1021/jacs.8b12203

Experimental method

X-RAY DIFFRACTION (0.93 Å)