2NSX

Structure of acid-beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease

Summary for 2NSX

Entry DOI	10.2210/pdb2nsx/pdb
Descriptor	Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (6 entities in total)
Functional Keywords	tim-barrel glycosidase cerezyme hydrolysis, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	225874.38
Authors	Lieberman, R.L.,Petsko, G.A.,Ringe, D. (deposition date: 2006-11-06, release date: 2006-12-26, Last modification date: 2023-08-30)
Primary citation	Lieberman, R.L.,Wustman, B.A.,Huertas, P.,Powe, A.C.,Pine, C.W.,Khanna, R.,Schlossmacher, M.G.,Ringe, D.,Petsko, G.A. Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease. Nat.Chem.Biol., 3:101-107, 2007 Cited by PubMed: 17187079 DOI: 10.1038/nchembio850 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation