2NSX
Structure of acid-beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Glucosylceramidase | polymer | 497 | 55640.2 | 4 | UniProt (P04062) Pfam (PF02055) Pfam (PF17189) In PDB | Homo sapiens (human) | Beta-glucocerebrosidase, Acid beta-glucosidase, D-glucosyl-N-acylsphingosine glucohydrolase, Alglucerase, Imiglucerase |
2 | A, B, C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
3 | D, A, B, C | SULFATE ION | non-polymer | 96.1 | 18 | Chemie (SO4) | |||
4 | A, C | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
5 | D, B | 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE | non-polymer | 147.2 | 2 | Chemie (IFM) | |||
6 | water | water | 18.0 | 1006 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 497 (UniProt: P04062)
PDB | External Database | Details |
---|---|---|
His 495 | Arg 534 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 222560.7 | |
Non-Polymers* | Number of molecules | 27 |
Total formula weight | 3313.7 | |
All* | Total formula weight | 225874.4 |