7RZH
 
 | | Insulin Degrading Enzyme O/O | | 分子名称: | Cysteine-free Insulin-degrading enzyme | | 著者 | Mancl, J.M, Liang, W.G, Tang, W.J. | | 登録日 | 2021-08-27 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
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7RZF
 | | Insulin Degrading Enzyme O/pC | | 分子名称: | Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain | | 著者 | Mancl, J.M, Liang, W.G, Tang, W.J. | | 登録日 | 2021-08-27 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
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7RZG
 | | Insulin Degrading Enzyme O/pO | | 分子名称: | Cysteine-free Insulin-degrading enzyme | | 著者 | Mancl, J.M, Liang, W.G, Tang, W.J. | | 登録日 | 2021-08-27 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
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7K1V
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3UX9
 | | Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus | | 分子名称: | Interferon alpha-1/13, ScFv antibody | | 著者 | Ouyang, S, Zhao, L.X, Liang, W, Shaw, N, Liu, Z.-J, Liang, M.-F. | | 登録日 | 2011-12-04 | | 公開日 | 2012-02-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus
J.Mol.Med., 2012
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4L3T
 | | Crystal Structure of Substrate-free Human Presequence Protease | | 分子名称: | ACETATE ION, GLYCEROL, Presequence protease, ... | | 著者 | King, J.V, Liang, W.G, Tang, W.J. | | 登録日 | 2013-06-06 | | 公開日 | 2013-07-03 | | 最終更新日 | 2014-07-23 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Molecular basis of substrate recognition and degradation by human presequence protease.
Structure, 22, 2014
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7C6P
 | | Bromodomain-containing 4 BD2 in complex with 3',4',7,8- Tetrahydroxyflavonoid | | 分子名称: | 2-[3,4-bis(oxidanyl)phenyl]-7,8-bis(oxidanyl)chromen-4-one, Bromodomain-containing protein 4 | | 著者 | Li, J, Yu, K, Luo, Y, Zheng, W, Liang, W, Zhu, J. | | 登録日 | 2020-05-22 | | 公開日 | 2021-05-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor.
J Enzyme Inhib Med Chem, 36, 2021
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4IOF
 | | Crystal structure analysis of Fab-bound human Insulin Degrading Enzyme (IDE) | | 分子名称: | Fab-bound IDE, heavy chain, light chain, ... | | 著者 | McCord, L.A, Liang, W.G, Hoey, R, Dowdell, E, Koide, A, Koide, S, Tang, W.J. | | 登録日 | 2013-01-07 | | 公開日 | 2013-07-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.353 Å) | | 主引用文献 | Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme.
Proc.Natl.Acad.Sci.USA, 110, 2013
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8IB0
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5WOB
 | | Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin | | 分子名称: | IDE-bound Fab heavy chain, IDE-bound Fab light chain, Insulin, ... | | 著者 | McCord, L.A, Liang, W.G, Farcasanu, M, Wang, A.G, Koide, S, Tang, W.J. | | 登録日 | 2017-08-01 | | 公開日 | 2018-04-18 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.95 Å) | | 主引用文献 | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
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5Y4M
 | | Discoidin domain of human CASPR2 | | 分子名称: | 1,2-ETHANEDIOL, human CASPR2 Disc domain | | 著者 | Liu, H, Xu, F, Zhang, J, Liang, W. | | 登録日 | 2017-08-04 | | 公開日 | 2018-08-08 | | 最終更新日 | 2019-02-20 | | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | | 主引用文献 | Structural mapping of hot spots within human CASPR2 discoidin domain for autoantibody recognition.
J. Autoimmun., 96, 2019
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1WOF
 | | Crystal Structure Of SARS-CoV Mpro in Complex with an Inhibitor N1 | | 分子名称: | 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]-L-ALANYL-L-VALYL-N~1~-((1S)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE | | 著者 | Yang, H, Bartlam, M, Xue, X, Yang, K, Liang, W, Rao, Z. | | 登録日 | 2004-08-18 | | 公開日 | 2005-08-30 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
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6AIC
 | | Crystal structures of the N-terminal domain of Staphylococcus aureus DEAD-box Cold shock RNA helicase CshA in complex with AMP | | 分子名称: | ADENOSINE MONOPHOSPHATE, DEAD-box ATP-dependent RNA helicase CshA | | 著者 | Tian, T, Chengliang, W, Xiaobao, C, Xuan, Z, Jianye, Z. | | 登録日 | 2018-08-22 | | 公開日 | 2018-11-21 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structures of the N-terminal domain of the Staphylococcus aureus DEAD-box RNA helicase CshA and its complex with AMP
Acta Crystallogr F Struct Biol Commun, 74, 2018
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3VCF
 | | SSV1 integrase C-terminal catalytic domain (174-335aa) | | 分子名称: | Probable integrase | | 著者 | Ouyang, S, Liang, W, Huang, L, Liu, Z.-J. | | 登録日 | 2012-01-04 | | 公開日 | 2012-05-30 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural and functional characterization of the C-terminal catalytic domain of SSV1 integrase.
Acta Crystallogr.,Sect.D, 68, 2012
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4NGE
 | | Crystal Structure of Human Presequence Protease in Complex with Amyloid-beta (1-40) | | 分子名称: | ACETATE ION, Beta-amyloid protein 40, GLYCEROL, ... | | 著者 | King, J.V, Liang, W.G, Tang, W.J. | | 登録日 | 2013-11-01 | | 公開日 | 2014-05-14 | | 最終更新日 | 2014-07-23 | | 実験手法 | X-RAY DIFFRACTION (2.704 Å) | | 主引用文献 | Molecular basis of substrate recognition and degradation by human presequence protease.
Structure, 22, 2014
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4DKS
 | | A spindle-shaped virus protein (chymotrypsin treated) | | 分子名称: | Probable integrase | | 著者 | Ouyang, S, Liang, W, Huang, L, Liu, Z.-J. | | 登録日 | 2012-02-04 | | 公開日 | 2012-05-30 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural and functional characterization of the C-terminal catalytic domain of SSV1 integrase.
Acta Crystallogr.,Sect.D, 68, 2012
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