4P5B
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![BU of 4p5b by Molmil](/molmil-images/mine/4p5b) | Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi bound with 5-Br dUMP | Descriptor: | 5-BROMO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ... | Authors: | Li, Y, Chen, W, Li, J, Xia, Z, Deng, Z, Zhou, J. | Deposit date: | 2014-03-15 | Release date: | 2015-12-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.274 Å) | Cite: | Crystal structure of a UMP/dUMP methylase PolB form Streptomyces cacaoi bound with 5-Br dUMP To Be Published
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4G70
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![BU of 4g70 by Molmil](/molmil-images/mine/4g70) | |
4G7S
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![BU of 4g7s by Molmil](/molmil-images/mine/4g7s) | |
4GP4
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![BU of 4gp4 by Molmil](/molmil-images/mine/4gp4) | Structure of Recombinant Cytochrome ba3 Oxidase mutant Y133F from Thermus thermophilus | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, COPPER (II) ION, Cytochrome c oxidase polypeptide 2A, ... | Authors: | Li, Y, Chen, Y, Stout, C.D. | Deposit date: | 2012-08-20 | Release date: | 2013-01-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Ligand Access to the Active Site in Thermus thermophilusba(3) and Bovine Heart aa(3) Cytochrome Oxidases. Biochemistry, 52, 2013
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4ZVV
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![BU of 4zvv by Molmil](/molmil-images/mine/4zvv) | Lactate dehydrogenase A in complex with a trisubstituted piperidine-2,4-dione inhibitor GNE-140 | Descriptor: | (2~{R})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one, L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Li, Y, Chen, Z, Eigenbrot, C. | Deposit date: | 2015-05-18 | Release date: | 2016-05-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition. Nat.Chem.Biol., 12, 2016
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3M4J
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![BU of 3m4j by Molmil](/molmil-images/mine/3m4j) | Crystal structure of N-acetyl-L-ornithine transcarbamylase complexed with PALAO | Descriptor: | N-acetylornithine carbamoyltransferase, N~2~-acetyl-N~5~-(phosphonoacetyl)-L-ornithine, SULFATE ION | Authors: | Li, Y, Yu, X, Allewell, N.M, Tuchman, M, Shi, D. | Deposit date: | 2010-03-11 | Release date: | 2010-07-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Reversible Post-Translational Carboxylation Modulates the Enzymatic Activity of N-Acetyl-l-ornithine Transcarbamylase. Biochemistry, 49, 2010
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5VZU
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![BU of 5vzu by Molmil](/molmil-images/mine/5vzu) | Crystal structure of the Skp1-FBXO31-cyclin D1 complex | Descriptor: | Cyclin D1, F-box only protein 31, PHOSPHATE ION, ... | Authors: | Li, Y, Jin, K, Hao, B. | Deposit date: | 2017-05-29 | Release date: | 2018-01-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of the phosphorylation-independent recognition of cyclin D1 by the SCFFBXO31 ubiquitin ligase. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7CYV
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![BU of 7cyv by Molmil](/molmil-images/mine/7cyv) | Crystal structure of FD20, a neutralizing single-chain variable fragment (scFv) in complex with SARS-CoV-2 Spike receptor-binding domain (RBD) | Descriptor: | Spike protein S1, The heavy chain variable region of the scFv FD20,The light chain variable region of the scFv FD20, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Li, Y, Li, T, Lai, Y, Cai, H, Yao, H, Li, D. | Deposit date: | 2020-09-04 | Release date: | 2021-09-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.13 Å) | Cite: | Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody. Embo Mol Med, 13, 2021
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7YTD
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![BU of 7ytd by Molmil](/molmil-images/mine/7ytd) | Cryo-EM structure of four human FcmR bound to IgM-Fc/J | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, Immunoglobulin J chain, ... | Authors: | Li, Y, Shen, H, Xiao, J. | Deposit date: | 2022-08-14 | Release date: | 2023-02-01 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.71 Å) | Cite: | Immunoglobulin M perception by Fc mu R. Nature, 615, 2023
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7YSG
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![BU of 7ysg by Molmil](/molmil-images/mine/7ysg) | Cryo-EM structure of human FcmR bound to sIgM | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, ... | Authors: | Li, Y, Shen, H, Xiao, J. | Deposit date: | 2022-08-12 | Release date: | 2023-02-01 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Immunoglobulin M perception by Fc mu R. Nature, 615, 2023
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7YTE
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7YTC
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![BU of 7ytc by Molmil](/molmil-images/mine/7ytc) | Cryo-EM structure of human FcmR bound to IgM-Fc/J | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, Immunoglobulin J chain, ... | Authors: | Li, Y, Shen, H, Xiao, J. | Deposit date: | 2022-08-14 | Release date: | 2023-02-01 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Immunoglobulin M perception by Fc mu R. Nature, 615, 2023
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1HQR
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![BU of 1hqr by Molmil](/molmil-images/mine/1hqr) | CRYSTAL STRUCTURE OF A SUPERANTIGEN BOUND TO THE HIGH-AFFINITY, ZINC-DEPENDENT SITE ON MHC CLASS II | Descriptor: | HLA-DR ALPHA CHAIN, HLA-DR BETA CHAIN, MYELIN BASIC PROTEIN, ... | Authors: | Li, Y, Li, H, Dimasi, N, Schlievert, P, Mariuzza, R. | Deposit date: | 2000-12-19 | Release date: | 2001-01-03 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II. Immunity, 14, 2001
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5J9S
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![BU of 5j9s by Molmil](/molmil-images/mine/5j9s) | ENL YEATS in complex with histone H3 acetylation at K27 | Descriptor: | H3K27ac peptide from Histone H3.1, Protein ENL, SULFATE ION | Authors: | Li, Y, Li, H. | Deposit date: | 2016-04-11 | Release date: | 2017-03-08 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.702 Å) | Cite: | ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia Nature, 543, 2017
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5F59
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![BU of 5f59 by Molmil](/molmil-images/mine/5f59) | The crystal structure of MLL3 SET domain | Descriptor: | Histone-lysine N-methyltransferase 2C, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | Authors: | Li, Y, Lei, M, Chen, Y. | Deposit date: | 2015-12-04 | Release date: | 2016-02-24 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.801 Å) | Cite: | Structural basis for activity regulation of MLL family methyltransferases. Nature, 530, 2016
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5F5E
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5F6L
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![BU of 5f6l by Molmil](/molmil-images/mine/5f6l) | The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L | Descriptor: | Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Li, Y, Lei, M, Chen, Y. | Deposit date: | 2015-12-06 | Release date: | 2016-02-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for activity regulation of MLL family methyltransferases. Nature, 530, 2016
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5F6K
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![BU of 5f6k by Molmil](/molmil-images/mine/5f6k) | Crystal structure of the MLL3-Ash2L-RbBP5 complex | Descriptor: | Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Li, Y, Lei, M, Chen, Y. | Deposit date: | 2015-12-06 | Release date: | 2016-02-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.411 Å) | Cite: | Structural basis for activity regulation of MLL family methyltransferases. Nature, 530, 2016
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4N4G
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![BU of 4n4g by Molmil](/molmil-images/mine/4n4g) | |
4N4I
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![BU of 4n4i by Molmil](/molmil-images/mine/4n4i) | Crystal structure of the Bromo-PWWP of the mouse zinc finger MYND-type containing 11 isoform alpha in complex with histone H3.3K36me3 | Descriptor: | DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, Peptide from Histone H3.3, ... | Authors: | Li, Y, Ren, Y, Li, H. | Deposit date: | 2013-10-08 | Release date: | 2014-03-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.999 Å) | Cite: | ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression Nature, 508, 2014
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4N4H
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![BU of 4n4h by Molmil](/molmil-images/mine/4n4h) | Crystal structure of the Bromo-PWWP of the mouse zinc finger MYND-type containing 11 isoform alpha in complex with histone H3.1K36me3 | Descriptor: | DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, Peptide from Histone H3.1, ... | Authors: | Li, Y, Ren, Y, Li, H. | Deposit date: | 2013-10-08 | Release date: | 2014-03-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression Nature, 508, 2014
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1QSS
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![BU of 1qss by Molmil](/molmil-images/mine/1qss) | DDGTP-TRAPPED CLOSED TERNARY COMPLEX OF THE LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS | Descriptor: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*AP*CP*CP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3', 5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DDG))-3', ... | Authors: | Li, Y, Mitaxov, V, Waksman, G. | Deposit date: | 1999-06-23 | Release date: | 1999-08-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation. Proc.Natl.Acad.Sci.USA, 96, 1999
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1QSY
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![BU of 1qsy by Molmil](/molmil-images/mine/1qsy) | DDATP-Trapped closed ternary complex of the large fragment of DNA Polymerase I from thermus aquaticus | Descriptor: | 2',3'-dideoxyadenosine triphosphate, 5'-D(*AP*TP*TP*GP*CP*GP*CP*CP*TP*P*GP*GP*TP*C)-3', 5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(2DA))-3', ... | Authors: | Li, Y, Mitaxov, V, Waksman, G. | Deposit date: | 1999-06-24 | Release date: | 1999-08-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation. Proc.Natl.Acad.Sci.USA, 96, 1999
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1QTM
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![BU of 1qtm by Molmil](/molmil-images/mine/1qtm) | DDTTP-TRAPPED CLOSED TERNARY COMPLEX OF THE LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS | Descriptor: | 5'-D(*AP*AP*AP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3', 5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(2DT))-3', DNA POLYMERASE I, ... | Authors: | Li, Y, Mitaxov, V, Waksman, G. | Deposit date: | 1999-06-28 | Release date: | 1999-08-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation. Proc.Natl.Acad.Sci.USA, 96, 1999
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3ETL
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![BU of 3etl by Molmil](/molmil-images/mine/3etl) | RadA recombinase from Methanococcus maripaludis in complex with AMPPNP | Descriptor: | DNA repair and recombination protein radA, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Li, Y, He, Y, Luo, Y. | Deposit date: | 2008-10-08 | Release date: | 2009-05-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Conservation of a conformational switch in RadA recombinase from Methanococcus maripaludis. Acta Crystallogr.,Sect.D, 65, 2009
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