2GO3
| Crystal structure of Aquifex aeolicus LpxC complexed with imidazole. | Descriptor: | CHLORIDE ION, GLYCEROL, IMIDAZOLE, ... | Authors: | Gennadios, H.A, Whittington, D.A, Li, X, Fierke, C.A, Christianson, D.W. | Deposit date: | 2006-04-12 | Release date: | 2006-07-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Mechanistic Inferences from the Binding of Ligands to LpxC, a Metal-Dependent Deacetylase Biochemistry, 45, 2006
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2GVE
| Time-of-Flight Neutron Diffraction Structure of D-Xylose Isomerase | Descriptor: | COBALT (II) ION, Xylose isomerase | Authors: | Katz, A.K, Li, X, Carrell, H.L, Hanson, B.L, Langan, P, Coates, L, Schoenborn, B.P, Glusker, J.P, Bunick, G.J. | Deposit date: | 2006-05-02 | Release date: | 2006-05-16 | Last modified: | 2023-08-30 | Method: | NEUTRON DIFFRACTION (2.2 Å) | Cite: | Locating active-site hydrogen atoms in D-xylose isomerase: Time-of-flight neutron diffraction. Proc.Natl.Acad.Sci.Usa, 103, 2006
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4OU6
| Crystal structure of DnaT84-153-dT10 ssDNA complex form 1 | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Primosomal protein 1 | Authors: | Liu, Z, Chen, P, Niu, L, Teng, M, Li, X. | Deposit date: | 2014-02-15 | Release date: | 2014-08-13 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode. Nucleic Acids Res., 42, 2014
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4OU7
| Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Primosomal protein 1 | Authors: | Liu, Z, Chen, P, Niu, L, Teng, M, Li, X. | Deposit date: | 2014-02-15 | Release date: | 2014-08-13 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode. Nucleic Acids Res., 42, 2014
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1ZTY
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1ZU0
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8YN7
| Cryo-EM structure of histamine H3 receptor in complex with immethridine and miniGo | Descriptor: | 4-(1H-imidazol-4-ylmethyl)pyridine, Antibody fragment scFv16, CHOLESTEROL, ... | Authors: | Zhang, X, Liu, G, Li, X, Gong, W. | Deposit date: | 2024-03-10 | Release date: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Structural basis of ligand recognition and activation of the histamine receptor family Nat Commun, 15, 2024
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8YN8
| Cryo-EM structure of histamine H3 receptor in complex with proxyfan and miniGo | Descriptor: | 5-(3-phenylmethoxypropyl)-1H-imidazole, Antibody fragment scFv16, CHOLESTEROL, ... | Authors: | Zhang, X, Liu, G, Li, X, Gong, W. | Deposit date: | 2024-03-10 | Release date: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Structural basis of ligand recognition and activation of the histamine receptor family Nat Commun, 15, 2024
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2OQI
| Human Dipeptidyl Peptidase IV (DPP4) with Piperidinone-constrained phenethylamine | Descriptor: | (4R,5R)-5-AMINO-1-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-2-ONE, Dipeptidyl peptidase 4 (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (Adenosine deaminase complexing protein 2) (ADABP) | Authors: | Pei, Z, Li, X, von Geldern, T.W, Longenecker, K.L, Pireh, D, Stewart, K.D, Backes, B.J, Lai, C, Lubben, T.H, Ballaron, S.J, Beno, D.W, Kempf-Grote, A.J, Sham, H.L, Trevillyan, J.M. | Deposit date: | 2007-01-31 | Release date: | 2007-04-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery and Structure-Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors. J.Med.Chem., 50, 2007
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6OYY
| Crystal structure of Mtb aspartate decarboxylase, pyrazinoic acid complex | Descriptor: | Aspartate 1-decarboxylase alpha chain, Aspartate 1-decarboxylase beta chain, PYRAZINE-2-CARBOXYLIC ACID | Authors: | Sun, Q, Li, X, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2019-05-15 | Release date: | 2020-02-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD. Nat Commun, 11, 2020
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6P02
| Crystal structure of Mtb aspartate decarboxylase, 6-Chlorine pyrazinoic acid complex | Descriptor: | 6-chloropyrazine-2-carboxylic acid, Aspartate 1-decarboxylase alpha chain, Aspartate 1-decarboxylase beta chain | Authors: | Sun, Q, Li, X, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2019-05-16 | Release date: | 2020-02-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD. Nat Commun, 11, 2020
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4EDL
| Crystal structure of beta-parvin CH2 domain | Descriptor: | 1,2-ETHANEDIOL, Beta-parvin | Authors: | Stiegler, A.L, Draheim, K.M, Li, X, Chayen, N.E, Calderwood, D.A, Boggon, T.J. | Deposit date: | 2012-03-27 | Release date: | 2012-08-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for paxillin binding and focal adhesion targeting of beta-parvin. J.Biol.Chem., 287, 2012
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4E7N
| Crystal Structure of AhV_TL-I, a Glycosylated Snake-venom Thrombin-like Enzyme from Agkistrodon halys | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Snake-venom Thrombin-like Enzyme | Authors: | Zeng, F, Li, X, Teng, M, Niu, L. | Deposit date: | 2012-03-18 | Release date: | 2012-04-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal Structure of AhV_TL-I, a Glycosylated Snake-venom Thrombin-like Enzyme from Agkistrodon halys to be published
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4ED5
| Crystal structure of the two N-terminal RRM domains of HuR complexed with RNA | Descriptor: | 1,2-ETHANEDIOL, 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE, 5'-R(*A*UP*UP*UP*UP*UP*AP*UP*UP*UP*U)-3', ... | Authors: | Wang, H, Zeng, F, Liu, Q, Niu, L, Teng, M, Li, X. | Deposit date: | 2012-03-27 | Release date: | 2012-05-23 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding. Acta Crystallogr.,Sect.D, 69, 2013
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4DM4
| The conserved domain of yeast Cdc73 | Descriptor: | Cell division control protein 73 | Authors: | Chen, H, Shi, N, Gao, Y, Li, X, Niu, L, Teng, M. | Deposit date: | 2012-02-06 | Release date: | 2012-08-22 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Crystallographic analysis of the conserved C-terminal domain of transcription factor Cdc73 from Saccharomyces cerevisiae reveals a GTPase-like fold. Acta Crystallogr.,Sect.D, 68, 2012
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6OZ8
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8U3E
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8U3D
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8U3G
| Structure of NAAG-bound Sialin | Descriptor: | ACETYL GROUP, ASPARTIC ACID, GLUTAMIC ACID, ... | Authors: | Schmiege, P, Li, X. | Deposit date: | 2023-09-07 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Structure of NAAG-bound Sialin To Be Published
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8U3F
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8U3H
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8G92
| Structure of inhibitor 16d-bound SPNS2 | Descriptor: | 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine, Sphingosine-1-phosphate transporter SPNS2 | Authors: | Chen, H, Li, X. | Deposit date: | 2023-02-21 | Release date: | 2023-05-24 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate. Cell, 186, 2023
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4EDN
| Crystal structure of beta-parvin CH2 domain in complex with paxillin LD1 motif | Descriptor: | Beta-parvin, Paxillin, SULFATE ION | Authors: | Stiegler, A.L, Draheim, K.M, Li, X, Chayen, N.E, Calderwood, D.A, Boggon, T.J. | Deposit date: | 2012-03-27 | Release date: | 2012-08-08 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for paxillin binding and focal adhesion targeting of beta-parvin. J.Biol.Chem., 287, 2012
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1XXE
| RDC refined solution structure of the AaLpxC/TU-514 complex | Descriptor: | 1,5-ANHYDRO-2-C-(CARBOXYMETHYL-N-HYDROXYAMIDE)-2-DEOXY-3-O-MYRISTOYL-D-GLUCITOL, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION | Authors: | Coggins, B.E, McClerren, A.L, Jiang, L, Li, X, Rudolph, J, Hindsgaul, O, Raetz, C.R.H, Zhou, P. | Deposit date: | 2004-11-04 | Release date: | 2004-11-23 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Refined Solution Structure of the LpxC-TU-514 Complex and pK(a) Analysis of an Active Site Histidine: Insights into the Mechanism and Inhibitor Design Biochemistry, 44, 2005
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6P1Y
| Crystal structure of Mtb aspartate decarboxylase mutant M117I | Descriptor: | AMMONIUM ION, Aspartate 1-decarboxylase alpha chain, Aspartate 1-decarboxylase beta chain, ... | Authors: | Sun, Q, Li, X, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2019-05-20 | Release date: | 2020-02-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD. Nat Commun, 11, 2020
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