4ED5

Crystal structure of the two N-terminal RRM domains of HuR complexed with RNA

Summary for 4ED5

• Entry DOI: 10.2210/pdb4ed5/pdb
• Descriptor: ELAV-like protein 1, 5'-R(*A*UP*UP*UP*UP*UP*AP*UP*UP*UP*U)-3', GLYCEROL, ... (6 entities in total)
• Functional Keywords: rrm, rna binding, nucleus, rna binding protein-rna complex, rna binding protein/rna
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q15717
• Total number of polymer chains: 4
• Total formula weight: 47265.61

Authors

Wang, H.,Zeng, F.,Liu, Q.,Niu, L.,Teng, M.,Li, X. (deposition date: 2012-03-27, release date: 2012-05-23, Last modification date: 2024-03-20)

• Primary citation: Wang, H.,Zeng, F.,Liu, Q.,Liu, H.,Liu, Z.,Niu, L.,Teng, M.,Li, X.; The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding.; Acta Crystallogr.,Sect.D, 69:373-380, 2013; PubMed: 23519412; DOI: 10.1107/S0907444912047828

Experimental method

X-RAY DIFFRACTION (2 Å)