4ED5

Crystal structure of the two N-terminal RRM domains of HuR complexed with RNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	ELAV-like protein 1	polymer	177	19812.4	2	UniProt (Q15717) Pfam (PF00076)	Homo sapiens (human)	Hu-antigen R, HuR
2	C, D (C, D)	5'-R(*A*UP*UP*UP*UP*UP*AP*UP*UP*UP*U)-3'	polymer	11	3368.9	2
3	E, F, G, H, I... (A, D)	GLYCEROL	non-polymer		92.1	7	Chemie (GOL)
4	J (A)	1-METHOXY-2-(2-METHOXYETHOXY)ETHANE	non-polymer		134.2	1	Chemie (M2M)
5	K, L (A)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
6	O, P, Q, R (A, B, C, D)	water	water		18.0	252	Chemie (HOH)

Sequence modifications

A, B: 18 - 186 (UniProt: Q15717)

PDB	External Database	Details
Leu 187	-	expression tag
Glu 188	-	expression tag
His 189	-	expression tag
His 190	-	expression tag
His 191	-	expression tag
His 192	-	expression tag
His 193	-	expression tag
His 194	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	46362.6
Non-Polymers*	Number of molecules	10
	Total formula weight	903.0
All*	Total formula weight	47265.6

*Water molecules are not included.