6OYY

Crystal structure of Mtb aspartate decarboxylase, pyrazinoic acid complex

Summary for 6OYY

• Entry DOI: 10.2210/pdb6oyy/pdb
• Descriptor: Aspartate 1-decarboxylase beta chain, Aspartate 1-decarboxylase alpha chain, PYRAZINE-2-CARBOXYLIC ACID, ... (4 entities in total)
• Functional Keywords: active, pyrazinoic acid, complex, structural genomics, tb structural genomics consortium, tbsgc, lyase
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); More
• Total number of polymer chains: 12
• Total formula weight: 96583.29

Authors

Sun, Q.,Li, X.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2019-05-15, release date: 2020-02-05, Last modification date: 2023-11-15)

• Primary citation: Sun, Q.,Li, X.,Perez, L.M.,Shi, W.,Zhang, Y.,Sacchettini, J.C.; The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD.; Nat Commun, 11:339-339, 2020; PubMed: 31953389; DOI: 10.1038/s41467-019-14238-3

Experimental method

X-RAY DIFFRACTION (2.7 Å)