6OYY

Crystal structure of Mtb aspartate decarboxylase, pyrazinoic acid complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004068	molecular_function	aspartate 1-decarboxylase activity
A	0006523	biological_process	alanine biosynthetic process
B	0004068	molecular_function	aspartate 1-decarboxylase activity
B	0006523	biological_process	alanine biosynthetic process
C	0004068	molecular_function	aspartate 1-decarboxylase activity
C	0006523	biological_process	alanine biosynthetic process
D	0004068	molecular_function	aspartate 1-decarboxylase activity
D	0006523	biological_process	alanine biosynthetic process
E	0004068	molecular_function	aspartate 1-decarboxylase activity
E	0006523	biological_process	alanine biosynthetic process
F	0004068	molecular_function	aspartate 1-decarboxylase activity
F	0006523	biological_process	alanine biosynthetic process
G	0004068	molecular_function	aspartate 1-decarboxylase activity
G	0006523	biological_process	alanine biosynthetic process
H	0004068	molecular_function	aspartate 1-decarboxylase activity
H	0006523	biological_process	alanine biosynthetic process
I	0004068	molecular_function	aspartate 1-decarboxylase activity
I	0006523	biological_process	alanine biosynthetic process
J	0004068	molecular_function	aspartate 1-decarboxylase activity
J	0006523	biological_process	alanine biosynthetic process
K	0004068	molecular_function	aspartate 1-decarboxylase activity
K	0006523	biological_process	alanine biosynthetic process
L	0004068	molecular_function	aspartate 1-decarboxylase activity
L	0006523	biological_process	alanine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue VGL B 201

Chain	Residue
B	THR57
B	TYR58
B	ASN72
B	GLY73
B	ALA74
B	ALA75
D	ARG54
D	ILE86
D	ILE88

---

site_id	AC2
Number of Residues	10
Details	binding site for residue VGL D 201

Chain	Residue
B	ARG54
B	ILE86
B	ILE88
D	PYR25
D	THR57
D	TYR58
D	ASN72
D	GLY73
D	ALA74
D	ALA75

---

site_id	AC3
Number of Residues	10
Details	binding site for residue VGL J 201

Chain	Residue
H	ARG54
H	ILE86
H	ILE88
J	PYR25
J	THR57
J	TYR58
J	ASN72
J	GLY73
J	ALA74
J	ALA75

---

site_id	AC4
Number of Residues	11
Details	binding site for residue VGL F 201

Chain	Residue
F	PYR25
F	THR57
F	TYR58
F	ASN72
F	GLY73
F	ALA74
F	ALA75
L	VAL47
L	ARG54
L	ILE86
L	ILE88

---

site_id	AC5
Number of Residues	9
Details	binding site for residue VGL L 201

Chain	Residue
J	ARG54
J	ILE88
L	PYR25
L	THR57
L	TYR58
L	ASN72
L	GLY73
L	ALA74
L	ALA75

---

site_id	AC6
Number of Residues	10
Details	binding site for residue VGL H 201

Chain	Residue
F	ARG54
F	ILE86
F	ILE88
H	PYR25
H	THR57
H	TYR58
H	ASN72
H	GLY73
H	ALA74
H	ALA75

---

site_id	AC7
Number of Residues	10
Details	binding site for Di-peptide PYR D 25 and VAL D 26

Chain	Residue
D	THR27
D	ILE28
D	ILE46
D	THR57
D	TYR58
D	ALA59
D	ILE60
D	GLY70
D	ASN72
D	VGL201

---

site_id	AC8
Number of Residues	10
Details	binding site for Di-peptide PYR F 25 and VAL F 26

Chain	Residue
F	THR27
F	ILE28
F	ILE46
F	THR57
F	TYR58
F	ALA59
F	ILE60
F	GLY70
F	ASN72
F	VGL201

---

site_id	AC9
Number of Residues	10
Details	binding site for Di-peptide PYR H 25 and VAL H 26

Chain	Residue
H	THR27
H	ILE28
H	ILE46
H	THR57
H	TYR58
H	ALA59
H	ILE60
H	GLY70
H	ASN72
H	VGL201

---

site_id	AD1
Number of Residues	10
Details	binding site for Di-peptide PYR J 25 and VAL J 26

Chain	Residue
J	THR27
J	ILE28
J	ILE46
J	THR57
J	TYR58
J	ALA59
J	ILE60
J	GLY70
J	ASN72
J	VGL201

---

site_id	AD2
Number of Residues	10
Details	binding site for Di-peptide PYR L 25 and VAL L 26

Chain	Residue
L	THR27
L	ILE28
L	ILE46
L	THR57
L	TYR58
L	ALA59
L	ILE60
L	GLY70
L	ASN72
L	VGL201

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_00446","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00446","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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