7Z13
 
 | | S. cerevisiae CMGE dimer nucleating origin DNA melting | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, ... | | 著者 | Lewis, J.S, Sousa, J.S, Costa, A. | | 登録日 | 2022-02-24 | | 公開日 | 2022-06-15 | | 最終更新日 | 2022-07-06 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Mechanism of replication origin melting nucleated by CMG helicase assembly.
Nature, 606, 2022
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7QHS
 | | S. cerevisiae CMGE nucleating origin DNA melting | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, ... | | 著者 | Lewis, J.S, Sousa, J.S, Costa, A. | | 登録日 | 2021-12-14 | | 公開日 | 2022-06-15 | | 最終更新日 | 2022-07-06 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Mechanism of replication origin melting nucleated by CMG helicase assembly.
Nature, 606, 2022
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8FEM
 | | Panicum vigratum Dihydroflavonol 4-reductase complexed with NADP | | 分子名称: | Dihydroflavonol 4-Reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Lewis, J.A, Kang, C. | | 登録日 | 2022-12-06 | | 公開日 | 2023-09-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Structural Similarities and Overlapping Activities among Dihydroflavonol 4-Reductase, Flavanone 4-Reductase, and Anthocyanidin Reductase Offer Metabolic Flexibility in the Flavonoid Pathway.
Int J Mol Sci, 24, 2023
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8FEN
 | | Panicum vigratum Dihydroflavonol 4-reductase complexed with NADP and DHQ | | 分子名称: | (2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Panicum virgatum Dihydroflavonol 4-Reductase | | 著者 | Lewis, J.A, Kang, C. | | 登録日 | 2022-12-06 | | 公開日 | 2023-09-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Structural Similarities and Overlapping Activities among Dihydroflavonol 4-Reductase, Flavanone 4-Reductase, and Anthocyanidin Reductase Offer Metabolic Flexibility in the Flavonoid Pathway.
Int J Mol Sci, 24, 2023
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6NP6
 | | Crystal structure of the sensor domain of the transcriptional regulator HcpR from Porphyromonas Gingivalis | | 分子名称: | Crp/Fnr family transcriptional regulator, GLYCEROL | | 著者 | Musayev, F.N, Belvin, B.R, Escalante, C.R, Turner, J, Scarsdale, J.N, Lewis, J.P. | | 登録日 | 2019-01-17 | | 公開日 | 2019-06-26 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Nitrosative Stress Sensing in Porphyromonas gingivalis: Structure and Mechanisms of the Heme Binding Transcriptional Regulator HcpR.
Acta Crystallogr D Struct Biol, 75, 2019
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3T22
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5T88
 | | Prolyl oligopeptidase from Pyrococcus furiosus | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, PROLINE, ... | | 著者 | Ellis-Guardiola, K, Lewis, J, Sukumar, N. | | 登録日 | 2016-09-06 | | 公開日 | 2017-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.902 Å) | | 主引用文献 | Crystal Structure and Conformational Dynamics of Pyrococcus furiosus Prolyl Oligopeptidase.
Biochemistry, 58, 2019
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5V30
 | | Crystal structure of the sensor domain of the transcriptional regulator HcpR from Porphyromonas Gingivalis | | 分子名称: | GLYCEROL, SULFATE ION, Transcriptional regulator | | 著者 | Musayev, F.N, Belvin, B.R, Escalante, C.R, Turner, J, Lewis, J.P. | | 登録日 | 2017-03-06 | | 公開日 | 2018-06-13 | | 最終更新日 | 2022-03-23 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Nitrosative stress sensing in Porphyromonas gingivalis: structure of and heme binding by the transcriptional regulator HcpR.
Acta Crystallogr D Struct Biol, 75, 2019
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1BE9
 | | THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95 IN COMPLEX WITH A C-TERMINAL PEPTIDE DERIVED FROM CRIPT. | | 分子名称: | CRIPT, PSD-95 | | 著者 | Doyle, D.A, Lee, A, Lewis, J, Kim, E, Sheng, M, Mackinnon, R. | | 登録日 | 1998-05-20 | | 公開日 | 1998-10-21 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.
Cell(Cambridge,Mass.), 85, 1996
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1BFE
 | | THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95 | | 分子名称: | PSD-95 | | 著者 | Doyle, D.A, Lee, A, Lewis, J, Kim, E, Sheng, M, Mackinnon, R. | | 登録日 | 1998-05-20 | | 公開日 | 1998-10-21 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.
Cell(Cambridge,Mass.), 85, 1996
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6CAN
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7JLY
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6P2V
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6P00
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3HO7
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7JU0
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2LZG
 | | NMR Structure of Mdm2 (6-125) with Pip-1 | | 分子名称: | E3 ubiquitin-protein ligase Mdm2, [(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid | | 著者 | Michelsen, K.B, Jordan, J.B, Lewis, J, Long, A.M, Yang, E, Rew, Y, Zhou, J, Yakowec, P, Schnier, P.D, Huang, X, Poppe, L. | | 登録日 | 2012-10-02 | | 公開日 | 2012-11-07 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Ordering of the N-Terminus of Human MDM2 by Small Molecule Inhibitors.
J.Am.Chem.Soc., 134, 2012
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4LU6
 | | Thermostabilized RebH | | 分子名称: | Flavin-dependent tryptophan halogenase RebH, PHOSPHATE ION | | 著者 | Poor, C.B, Lewis, J.C. | | 登録日 | 2013-07-24 | | 公開日 | 2014-06-11 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Improving the Stability and Catalyst Lifetime of the Halogenase RebH By Directed Evolution.
Chembiochem, 15, 2014
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2AGN
 | | Fitting of hepatitis C virus internal ribosome entry site domains into the 15 A Cryo-EM map of a HCV IRES-80S ribosome (H. sapiens) complex | | 分子名称: | 6 nt A-RNA helix, HCV IRES DOMAIN II, HCV IRES IIIABC, ... | | 著者 | Boehringer, D, Thermann, R, Ostareck-Lederer, A, Lewis, J.D, Stark, H. | | 登録日 | 2005-07-27 | | 公開日 | 2006-07-25 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (15 Å) | | 主引用文献 | Structure of the hepatitis C Virus IRES bound to the human 80S ribosome: remodeling of the HCV IRES
Structure, 13, 2005
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4CB7
 | | Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8e) | | 分子名称: | 5-[2-(2-azanyl-7-methyl-6-oxidanylidene-1H-purin-9-ium-9-yl)ethanoyl]-2-oxidanyl-benzoic acid, GLYCEROL, POLYMERASE BASIC SUBUNIT 2 | | 著者 | Pautus, S, Sehr, P, Lewis, J, Fortune, A, Wolkerstorfer, A, Szolar, O, Gulligay, D, Lunardi, T, Decout, J.L, Cusack, S. | | 登録日 | 2013-10-10 | | 公開日 | 2013-10-30 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain
J.Med.Chem., 56, 2013
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4CB5
 | | Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f) | | 分子名称: | 9-N-(3-CARBOXY-4-HYDROXYPHENYL)KETOMETHYL-7-N-METHYLGUANINE, CHLORIDE ION, POLYMERASE BASIC SUBUNIT 2 | | 著者 | Pautus, S, Sehr, P, Lewis, J, Fortune, A, Wolkerstorfer, A, Szolar, O, Gulligay, D, Lunardi, T, Decout, J.L, Cusack, S. | | 登録日 | 2013-10-10 | | 公開日 | 2013-10-30 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain
J.Med.Chem., 56, 2013
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4CB6
 | | Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 11) | | 分子名称: | 2,9-N,N-DI(4-CARBOXYBUTYL)-7-N-METHYLGUANINE, IODIDE ION, POLYMERASE BASIC SUBUNIT 2 | | 著者 | Pautus, S, Sehr, P, Lewis, J, Fortune, A, Wolkerstorfer, A, Szolar, O, Gulligay, D, Lunardi, T, Decout, J.L, Cusack, S. | | 登録日 | 2013-10-10 | | 公開日 | 2013-10-30 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain
J.Med.Chem., 56, 2013
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4CB4
 | | Structure of Influenza A H5N1 PB2 cap-binding domain with bound m7GTP | | 分子名称: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, POLYMERASE BASIC SUBUNIT 2 | | 著者 | Pautus, S, Sehr, P, Lewis, J, Fortune, A, Wolkerstorfer, A, Szolar, O, Gulligay, D, Lunardi, T, Decout, J.L, Cusack, S. | | 登録日 | 2013-10-10 | | 公開日 | 2013-10-30 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain
J.Med.Chem., 56, 2013
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2VQZ
 | | Structure of the cap-binding domain of influenza virus polymerase subunit PB2 with bound m7GTP | | 分子名称: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, POLYMERASE BASIC PROTEIN 2 | | 著者 | Guilligay, D, Tarendeau, F, Resa-Infante, P, Coloma, R, Crepin, T, Sehr, P, Lewis, J, Ruigrok, R.W.H, Ortin, J, Hart, D.J, Cusack, S. | | 登録日 | 2008-03-21 | | 公開日 | 2008-05-13 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The Structural Basis for CAP Binding by Influenza Virus Polymerase Subunit Pb2.
Nat.Struct.Mol.Biol., 15, 2008
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2MHS
 | | NMR Structure of human Mcl-1 | | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1 | | 著者 | Liu, G, Poppe, L, Aoki, K, Yamane, H, Lewis, J, Szyperski, T. | | 登録日 | 2013-12-04 | | 公開日 | 2014-05-14 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | High-Quality NMR Structure of Human Anti-Apoptotic Protein Domain Mcl-1(171-327) for Cancer Drug Design.
Plos One, 9, 2014
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