4CB4

Structure of Influenza A H5N1 PB2 cap-binding domain with bound m7GTP

Summary for 4CB4

Entry DOI	10.2210/pdb4cb4/pdb
Related	4CB5
Descriptor	POLYMERASE BASIC SUBUNIT 2, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	transferase, cap-binding inhibitors
Biological source	INFLUENZA A VIRUS
Total number of polymer chains	1
Total formula weight	19533.53
Authors	Pautus, S.,Sehr, P.,Lewis, J.,Fortune, A.,Wolkerstorfer, A.,Szolar, O.,Gulligay, D.,Lunardi, T.,Decout, J.L.,Cusack, S. (deposition date: 2013-10-10, release date: 2013-10-30, Last modification date: 2023-12-20)
Primary citation	Pautus, S.,Sehr, P.,Lewis, J.,Fortune, A.,Wolkerstorfer, A.,Szolar, O.,Gulligay, D.,Lunardi, T.,Decout, J.L.,Cusack, S. New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain J.Med.Chem., 56:8915-, 2013 Cited by PubMed: 24134208 DOI: 10.1021/JM401369Y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation