2VKJ
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![BU of 2vkj by Molmil](/molmil-images/mine/2vkj) | Structure of the soluble domain of the membrane protein TM1634 from Thermotoga maritima | Descriptor: | SULFATE ION, TM1634 | Authors: | McCleverty, C.J, Columbus, L, Kreusch, A, Lesley, S.A, Joint Center for Structural Genomics (JCSG) | Deposit date: | 2007-12-19 | Release date: | 2008-04-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure and Ligand Binding of the Soluble Domain of a Thermotoga Maritima Membrane Protein of Unknown Function Tm1634. Protein Sci., 17, 2008
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2VKO
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![BU of 2vko by Molmil](/molmil-images/mine/2vko) | Structure of the soluble domain of the membrane protein TM1634 from Thermotoga maritima | Descriptor: | HEXAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, TM1634 | Authors: | McCleverty, C.J, Columbus, L, Kreusch, A, Lesley, S.A, Joint Center for Structural Genomics (JCSG) | Deposit date: | 2007-12-20 | Release date: | 2008-04-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structure and Ligand Binding of the Soluble Domain of a Thermotoga Maritima Membrane Protein of Unknown Function Tm1634. Protein Sci., 17, 2008
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2IUB
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![BU of 2iub by Molmil](/molmil-images/mine/2iub) | Crystal structure of a divalent metal ion transporter CorA at 2.9 A resolution. | Descriptor: | CHLORIDE ION, DIVALENT CATION TRANSPORT-RELATED PROTEIN, MAGNESIUM ION | Authors: | Eshaghi, S, Niegowski, D, Kohl, A, Martinez Molina, D, Lesley, S.A, Nordlund, P. | Deposit date: | 2006-06-01 | Release date: | 2006-08-03 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structure of a Divalent Metal Ion Transporter Cora at 2.9 Angstrom Resolution. Science, 313, 2006
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1T6R
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![BU of 1t6r by Molmil](/molmil-images/mine/1t6r) | Solution structure of TM1442, a putative anti sigma factor antagonist in phosphorylated state | Descriptor: | Putative anti-sigma factor antagonist TM1442 | Authors: | Etezady-Esfarjani, T, Placzek, W, Herrmann, T, Lesley, S.A, Wuthrich, K, Joint Center for Structural Genomics (JCSG) | Deposit date: | 2004-05-07 | Release date: | 2005-05-24 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Solution structures of the putative anti-sigma-factor antagonist TM1442 from Thermotoga maritima in the free and phosphorylated states. Magn.Reson.Chem., 44 Spec No, 2006
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1T3V
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![BU of 1t3v by Molmil](/molmil-images/mine/1t3v) | The NMR solution structure of TM1816 | Descriptor: | conserved hypothetical protein | Authors: | Columbus, L, Peti, W, Herrmann, T, Etazady, T, Klock, H, Lesley, S, Wuthrich, K, Joint Center for Structural Genomics (JCSG) | Deposit date: | 2004-04-27 | Release date: | 2004-12-14 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | NMR structure determination of the conserved hypothetical protein TM1816 from Thermotoga maritima. Proteins, 60, 2005
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3G4C
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![BU of 3g4c by Molmil](/molmil-images/mine/3g4c) | |
3G4A
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![BU of 3g4a by Molmil](/molmil-images/mine/3g4a) | |
3RU2
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![BU of 3ru2 by Molmil](/molmil-images/mine/3ru2) | Crystal structure of tm0922, a fusion of a domain of unknown function and ADP/ATP-dependent NAD(P)H-hydrate dehydratase from Thermotoga maritima soaked with NADPH. | Descriptor: | BETA-6-HYDROXY-1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ... | Authors: | Shumilin, I.A, Cymborowski, M, Lesley, S.A, Minor, W. | Deposit date: | 2011-05-04 | Release date: | 2011-07-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Identification of unknown protein function using metabolite cocktail screening. Structure, 20, 2012
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2OP3
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![BU of 2op3 by Molmil](/molmil-images/mine/2op3) | The structure of cathepsin S with a novel 2-arylphenoxyacetaldehyde inhibitor derived by the Substrate Activity Screening (SAS) method | Descriptor: | 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, 2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL, Cathepsin S, ... | Authors: | Spraggon, G, Inagaki, H, Tsuruoka, H, Hornsby, M, Lesley, S.A, Ellman, J.A. | Deposit date: | 2007-01-26 | Release date: | 2007-05-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode. J.Med.Chem., 50, 2007
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1YC1
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![BU of 1yc1 by Molmil](/molmil-images/mine/1yc1) | Crystal Structures of human HSP90alpha complexed with dihydroxyphenylpyrazoles | Descriptor: | 4-(1,3-BENZODIOXOL-5-YL)-5-(5-ETHYL-2,4-DIHYDROXYPHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID, Heat shock protein HSP 90-alpha | Authors: | Kreusch, A, Han, S, Brinker, A, Zhou, V, Choi, H, He, Y, Lesley, S.A, Caldwell, J, Gu, X. | Deposit date: | 2004-12-21 | Release date: | 2005-02-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles. Bioorg.Med.Chem.Lett., 15, 2005
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1YC4
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![BU of 1yc4 by Molmil](/molmil-images/mine/1yc4) | Crystal structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles | Descriptor: | 4-(1H-IMIDAZOL-4-YL)-3-(5-ETHYL-2,4-DIHYDROXY-PHENYL)-1H-PYRAZOLE, Heat shock protein HSP 90-alpha | Authors: | Kreusch, A, Han, S, Brinker, A, Zhou, V, Choi, H, He, Y, Lesley, S.A, Caldwell, J, Gu, X. | Deposit date: | 2004-12-21 | Release date: | 2005-02-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles. Bioorg.Med.Chem.Lett., 15, 2005
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1YC3
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![BU of 1yc3 by Molmil](/molmil-images/mine/1yc3) | Crystal Structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles | Descriptor: | 4-(1,3-BENZODIOXOL-5-YL)-5-(5-ETHYL-2,4-DIHYDROXYPHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID, Heat shock protein HSP 90-alpha | Authors: | Kreusch, A, Han, S, Brinker, A, Zhou, V, Choi, H, He, Y, Lesley, S.A, Caldwell, J, Gu, X. | Deposit date: | 2004-12-21 | Release date: | 2005-02-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles. Bioorg.Med.Chem.Lett., 15, 2005
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2X65
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![BU of 2x65 by Molmil](/molmil-images/mine/2x65) | Crystal structure of T. maritima GDP-mannose pyrophosphorylase in complex with mannose-1-phosphate. | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 1-O-phosphono-alpha-D-mannopyranose, ... | Authors: | Pelissier, M.C, Lesley, S, Kuhn, P, Bourne, Y. | Deposit date: | 2010-02-15 | Release date: | 2010-06-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Insights Into the Catalytic Mechanism of Bacterial Guanosine-Diphospho-D-Mannose Pyrophosphorylase and its Regulation by Divalent Ions. J.Biol.Chem., 285, 2010
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2X5S
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2X5Z
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![BU of 2x5z by Molmil](/molmil-images/mine/2x5z) | Crystal structure of T. maritima GDP-mannose pyrophosphorylase in complex with GDP-mannose. | Descriptor: | GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, MAGNESIUM ION, MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE | Authors: | Pelissier, M.C, Lesley, S, Kuhn, P, Bourne, Y. | Deposit date: | 2010-02-12 | Release date: | 2010-06-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Insights Into the Catalytic Mechanism of Bacterial Guanosine-Diphospho-D-Mannose Pyrophosphorylase and its Regulation by Divalent Ions. J.Biol.Chem., 285, 2010
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2Q7D
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![BU of 2q7d by Molmil](/molmil-images/mine/2q7d) | Crystal Structure of Human Inositol 1,3,4-Trisphosphate 5/6-kinase (ITPK1) in complex with AMPPNP and Mn2+ | Descriptor: | Inositol-tetrakisphosphate 1-kinase, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Chamberlain, P.P, Lesley, S.A, Spraggon, G. | Deposit date: | 2007-06-06 | Release date: | 2007-07-03 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Integration of inositol phosphate signaling pathways via human ITPK1. J.Biol.Chem., 282, 2007
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2X60
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![BU of 2x60 by Molmil](/molmil-images/mine/2x60) | Crystal structure of T. maritima GDP-mannose pyrophosphorylase in complex with GTP. | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE | Authors: | Pelissier, M.C, Lesley, S, Kuhn, P, Bourne, Y. | Deposit date: | 2010-02-12 | Release date: | 2010-06-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Insights Into the Catalytic Mechanism of Bacterial Guanosine-Diphospho-D-Mannose Pyrophosphorylase and its Regulation by Divalent Ions. J.Biol.Chem., 285, 2010
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2X9Y
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![BU of 2x9y by Molmil](/molmil-images/mine/2x9y) | STRUCTURE OF THE PILUS BACKBONE (RRGB) FROM STREPTOCOCCUS PNEUMONIAE | Descriptor: | CELL WALL SURFACE ANCHOR FAMILY PROTEIN | Authors: | Spraggon, G, Koesema, E, Scarselli, M, Malito, E, Biagini, M, Norais, N, Emolo, C, Barocchi, M.A, Giusti, F, Hilleringmann, M, Rappuoli, R, Lesley, S, Covacci, A, Masignani, V, Ferlenghi, I. | Deposit date: | 2010-03-25 | Release date: | 2010-06-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Supramolecular Organization of the Repetitive Backbone Unit of the Streptococcus Pneumoniae Pilus. Plos One, 5, 2010
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2QB5
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![BU of 2qb5 by Molmil](/molmil-images/mine/2qb5) | Crystal Structure of Human Inositol 1,3,4-Trisphosphate 5/6-Kinase (ITPK1) in Complex with ADP and Mn2+ | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Inositol-tetrakisphosphate 1-kinase, MANGANESE (II) ION, ... | Authors: | Chamberlain, P.P, Lesley, S.A, Spraggon, G. | Deposit date: | 2007-06-15 | Release date: | 2007-07-03 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Integration of inositol phosphate signaling pathways via human ITPK1. J.Biol.Chem., 282, 2007
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2X9W
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![BU of 2x9w by Molmil](/molmil-images/mine/2x9w) | STRUCTURE OF THE PILUS BACKBONE (RRGB) FROM STREPTOCOCCUS PNEUMONIAE | Descriptor: | CELL WALL SURFACE ANCHOR FAMILY PROTEIN, GLYCEROL | Authors: | Spraggon, G, Koesema, E, Scarselli, M, Malito, E, Biagini, M, Norais, N, Emolo, C, Barocchi, M.A, Giusti, F, Hilleringmann, M, Rappuoli, R, Lesley, S, Covacci, A, Masignani, V, Ferlenghi, I. | Deposit date: | 2010-03-25 | Release date: | 2010-06-30 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Supramolecular Organization of the Repetitive Backbone Unit of the Streptococcus Pneumoniae Pilus. Plos One, 5, 2010
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2X9Z
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![BU of 2x9z by Molmil](/molmil-images/mine/2x9z) | STRUCTURE OF THE PILUS BACKBONE (RRGB) FROM STREPTOCOCCUS PNEUMONIAE | Descriptor: | CELL WALL SURFACE ANCHOR FAMILY PROTEIN | Authors: | Spraggon, G, Koesema, E, Scarselli, M, Malito, E, Biagini, M, Norais, N, Emolo, C, Barocchi, M.A, Giusti, F, Hilleringmann, M, Rappuoli, R, Lesley, S, Covacci, A, Masignani, V, Ferlenghi, I. | Deposit date: | 2010-03-25 | Release date: | 2010-06-30 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Supramolecular Organization of the Repetitive Backbone Unit of the Streptococcus Pneumoniae Pilus. Plos One, 5, 2010
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2X9X
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![BU of 2x9x by Molmil](/molmil-images/mine/2x9x) | STRUCTURE OF THE PILUS BACKBONE (RRGB) FROM STREPTOCOCCUS PNEUMONIAE | Descriptor: | CELL WALL SURFACE ANCHOR FAMILY PROTEIN, IMIDAZOLE, SODIUM ION | Authors: | Spraggon, G, Koesema, E, Scarselli, M, Malito, E, Biagini, M, Norais, N, Emolo, C, Barocchi, M.A, Giusti, F, Hilleringmann, M, Rappuoli, R, Lesley, S, Covacci, A, Masignani, V, Ferlenghi, I. | Deposit date: | 2010-03-25 | Release date: | 2010-06-30 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Supramolecular Organization of the Repetitive Backbone Unit of the Streptococcus Pneumoniae Pilus. Plos One, 5, 2010
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2AQX
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![BU of 2aqx by Molmil](/molmil-images/mine/2aqx) | Crystal Structure of the Catalytic and CaM-Binding domains of Inositol 1,4,5-Trisphosphate 3-Kinase B | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PREDICTED: inositol 1,4,5-trisphosphate 3-kinase B | Authors: | Chamberlain, P.P, Sandberg, M.L, Sauer, K, Cooke, M.P, Lesley, S.A, Spraggon, G. | Deposit date: | 2005-08-18 | Release date: | 2005-12-06 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B Biochemistry, 44, 2005
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3L4B
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![BU of 3l4b by Molmil](/molmil-images/mine/3l4b) | Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima | Descriptor: | ADENOSINE MONOPHOSPHATE, TrkA K+ Channel protein TM1088A, TrkA K+ Channel protein TM1088B, ... | Authors: | Deller, M.C, Johnson, H.A, Miller, M, Spraggon, G, Wilson, I.A, Lesley, S.A, Joint Center for Structural Genomics (JCSG) | Deposit date: | 2009-12-18 | Release date: | 2010-02-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima To be Published
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2QTW
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![BU of 2qtw by Molmil](/molmil-images/mine/2qtw) | The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Proprotein convertase subtilisin/kexin type 9, ... | Authors: | Hampton, E.N, Knuth, M.W, Li, J, Harris, J.L, Lesley, S.A, Spraggon, G. | Deposit date: | 2007-08-02 | Release date: | 2007-09-18 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain. Proc.Natl.Acad.Sci.Usa, 104, 2007
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