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PDB: 36 件
5MZN
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BU of 5mzn by Molmil
Helicase Sen1
分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ...
著者Leonaite, B, Basquin, J, Conti, E.
登録日2017-02-01
公開日2017-04-19
最終更新日2017-06-14
実験手法X-RAY DIFFRACTION (1.787 Å)
主引用文献Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase family.
EMBO J., 36, 2017
4POL
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BU of 4pol by Molmil
Crystal structures of thioredoxin with mesna at 2.8A resolution
分子名称: 1-THIOETHANESULFONIC ACID, Thioredoxin
著者Sridhar, V, Chie-Leon, B, Badger, J, Nienaber, V.L, Hausheer, F.H.
登録日2014-02-26
公開日2014-10-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献BNP7787 Forms Novel Covalent Adducts on Human Thioredoxin and Modulates Thioredoxin Activity
J Pharmacol Clin Toxicol, 2, 2014
4POK
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BU of 4pok by Molmil
Crystal structures of thioredoxin with mesna at 2.5A resolution
分子名称: 1-THIOETHANESULFONIC ACID, Thioredoxin
著者Sridhar, V, Chie-Leon, B, Badger, J, Nienaber, V.L, Hausheer, F.H.
登録日2014-02-25
公開日2014-10-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献BNP7787 Forms Novel Covalent Adducts on Human Thioredoxin and Modulates Thioredoxin Activity
J Pharmacol Clin Toxicol, 2, 2014
4POM
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BU of 4pom by Molmil
Crystal structures of thioredoxin with mesna at 1.85A resolution
分子名称: 1-THIOETHANESULFONIC ACID, Thioredoxin
著者Sridhar, V, Chie-Leon, B, Badger, J, Nienaber, V.L, Hausheer, F.H.
登録日2014-02-26
公開日2014-10-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献BNP7787 Forms Novel Covalent Adducts on Human Thioredoxin and Modulates Thioredoxin Activity
J Pharmacol Clin Toxicol, 2, 2014
3PMO
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BU of 3pmo by Molmil
The structure of LpxD from Pseudomonas aeruginosa at 1.3 A resolution
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
著者Badger, J, Chie-Leon, B, Logan, C, Sridhar, V, Sankaran, B, Zwart, P.H, Nienaber, V.
登録日2010-11-17
公開日2011-07-27
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献The structure of LpxD from Pseudomonas aeruginosa at 1.3 A resolution.
Acta Crystallogr.,Sect.F, 67, 2011
4TZ4
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BU of 4tz4 by Molmil
Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide
分子名称: DNA damage-binding protein 1, Protein cereblon, S-Lenalidomide, ...
著者Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B, Riley, M.
登録日2014-07-09
公開日2014-08-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
To Be Published
4TT7
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BU of 4tt7 by Molmil
Crystal structure of human ALK with a covalent modification
分子名称: 1,2-ETHANEDIOL, 1-THIOETHANESULFONIC ACID, ALK tyrosine kinase receptor
著者Badger, J, Sridhar, V, Chie-Leon, B, Nienaber, V.L, Hausheer, F.H.
登録日2014-06-19
公開日2015-02-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Novel covalent modification of human anaplastic lymphoma kinase (ALK) and potentiation of crizotinib-mediated inhibition of ALK activity by BNP7787.
Onco Targets Ther, 8, 2015
4TZU
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BU of 4tzu by Molmil
Crystal Structure of Murine Cereblon in Complex with Pomalidomide
分子名称: Protein cereblon, S-Pomalidomide, SULFATE ION, ...
著者Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B.
登録日2014-07-10
公開日2014-08-06
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
to be published
4TZC
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BU of 4tzc by Molmil
Crystal Structure of Murine Cereblon in Complex with Thalidomide
分子名称: Protein cereblon, S-Thalidomide, SULFATE ION, ...
著者Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B.
登録日2014-07-10
公開日2014-08-06
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
to be published
4E6T
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BU of 4e6t by Molmil
Structure of LpxA from Acinetobacter baumannii at 1.8A resolution (P212121 form)
分子名称: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, CITRATE ANION
著者Badger, J, Chie-Leon, B, Logan, C, Sridhar, V, Sankaran, B, Zwart, P.H, Nienaber, V.
登録日2012-03-15
公開日2012-12-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure determination of LpxA from the lipopolysaccharide-synthesis pathway of Acinetobacter baumannii.
Acta Crystallogr.,Sect.F, 68, 2012
4E79
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BU of 4e79 by Molmil
Structure of LpxD from Acinetobacter baumannii at 2.66A resolution (P4322 form)
分子名称: UDP-3-O-acylglucosamine N-acyltransferase
著者Badger, J, Chie-Leon, B, Logan, C, Sridhar, V, Sankaran, B, Zwart, P.H, Nienaber, V.
登録日2012-03-16
公開日2013-01-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献Structure determination of LpxD from the lipopolysaccharide-synthesis pathway of Acinetobacter baumannii.
Acta Crystallogr.,Sect.F, 69, 2013
4E75
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BU of 4e75 by Molmil
Structure of LpxD from Acinetobacter baumannii at 2.85A resolution (P21 form)
分子名称: UDP-3-O-acylglucosamine N-acyltransferase
著者Badger, J, Chie-Leon, B, Logan, C, Sridhar, V, Sankaran, B, Zwart, P.H, Nienaber, V.
登録日2012-03-16
公開日2013-01-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Structure determination of LpxD from the lipopolysaccharide-synthesis pathway of Acinetobacter baumannii.
Acta Crystallogr.,Sect.F, 69, 2013
4E6U
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BU of 4e6u by Molmil
Structure of LpxA from Acinetobacter baumannii at 1.4A resolution (P63 form)
分子名称: 1,2-ETHANEDIOL, Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, SULFATE ION
著者Badger, J, Chie-Leon, B, Logan, C, Sridhar, V, Sankaran, B, Zwart, P.H, Nienaber, V.
登録日2012-03-16
公開日2012-12-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献Structure determination of LpxA from the lipopolysaccharide-synthesis pathway of Acinetobacter baumannii.
Acta Crystallogr.,Sect.F, 68, 2012
4LM3
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BU of 4lm3 by Molmil
Crystal structure of PDE10A2 with fragment ZT464
分子名称: 1,2-ETHANEDIOL, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethanone, NICKEL (II) ION, ...
著者Sridhar, V, Badger, J, Logan, C, Chie-Leon, B, Nienaber, V.
登録日2013-07-09
公開日2014-02-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
4LM1
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BU of 4lm1 by Molmil
Crystal structure of PDE10A2 with fragment ZT450
分子名称: 5-nitroquinoline, NICKEL (II) ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
著者Sridhar, V, Badger, J, Logan, C, Chie-Leon, B, Nienaber, V.
登録日2013-07-09
公開日2014-02-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
4LLX
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BU of 4llx by Molmil
Crystal structure of PDE10A2 with fragment ZT434
分子名称: 4,6-dimethylpyrimidin-2-amine, NICKEL (II) ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
著者Sridhar, V, Badger, J, Logan, C, Chie-Leon, B, Nienaber, V.
登録日2013-07-09
公開日2014-02-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
4LM2
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BU of 4lm2 by Molmil
Crystal structure of PDE10A2 with fragment ZT462
分子名称: 2,3-dihydro-1,4-benzodioxin-6-ylmethanol, NICKEL (II) ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
著者Sridhar, V, Badger, J, Logan, C, Chie-Leon, B, Nienaber, V.
登録日2013-07-09
公開日2014-02-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
4LLJ
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BU of 4llj by Molmil
Crystal structure of PDE10A2 with fragment ZT214
分子名称: 2H-isoindole-1,3-diamine, NICKEL (II) ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
著者Sridhar, V, Badger, J, Logan, C, Chie-Leon, B, Nienaber, V.
登録日2013-07-09
公開日2014-02-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
4LM0
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BU of 4lm0 by Molmil
Crystal structure of PDE10A2 with fragment ZT448
分子名称: 5-NITROINDAZOLE, NICKEL (II) ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
著者Sridhar, V, Badger, J, Logan, C, Chie-Leon, B, Nienaber, V.
登録日2013-07-09
公開日2014-02-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
4LLK
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BU of 4llk by Molmil
Crystal structure of PDE10A2 with fragment ZT217
分子名称: 2-methylquinazolin-4(3H)-one, NICKEL (II) ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
著者Sridhar, V, Badger, J, Logan, C, Chie-Leon, B, Nienaber, V.
登録日2013-07-09
公開日2014-02-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
1XBA
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BU of 1xba by Molmil
Crystal structure of apo syk tyrosine kinase domain
分子名称: Tyrosine-protein kinase SYK
著者Atwell, S, Adams, J.M, Badger, J, Buchanan, M.D, Feil, I.K, Froning, K.J, Gao, X, Hendle, J, Keegan, K, Leon, B.C, Muller-Deickmann, H.J, Nienaber, V.L, Noland, B.W, Post, K, Rajashankar, K.R, Ramos, A, Russell, M, Burley, S.K, Buchanan, S.G.
登録日2004-08-30
公開日2004-11-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.
J.Biol.Chem., 279, 2004
4LLP
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BU of 4llp by Molmil
Crystal structure of PDE10A2 with fragment ZT401
分子名称: 4-amino-2-methylphenol, NICKEL (II) ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
著者Sridhar, V, Badger, J, Logan, C, Chie-Leon, B, Nienaber, V.
登録日2013-07-09
公開日2014-02-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
4LM4
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BU of 4lm4 by Molmil
Crystal structure of PDE10A2 with fragment ZT902
分子名称: NICKEL (II) ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, quinazolin-4(1H)-one
著者Sridhar, V, Badger, J, Logan, C, Chie-Leon, B, Nienaber, V.
登録日2013-07-10
公開日2014-02-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19, 2014
1XBB
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BU of 1xbb by Molmil
Crystal structure of the syk tyrosine kinase domain with Gleevec
分子名称: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Tyrosine-protein kinase SYK
著者Nienaber, V.L, Atwell, S, Adams, J.M, Badger, J, Buchanan, M.D, Feil, I.K, Froning, K.J, Gao, X, Hendle, J, Keegan, K, Leon, B.C, Muller-Deickmann, H.J, Noland, B.W, Post, K, Rajashankar, K.R, Ramos, A, Russell, M, Burley, S.K, Buchanan, S.G.
登録日2004-08-30
公開日2004-11-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase
J.Biol.Chem., 279, 2004
1XBC
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BU of 1xbc by Molmil
Crystal structure of the syk tyrosine kinase domain with Staurosporin
分子名称: STAUROSPORINE, Tyrosine-protein kinase SYK
著者Badger, J, Atwell, S, Adams, J.M, Buchanan, M.D, Feil, I.K, Froning, K.J, Gao, X, Hendle, J, Keegan, K, Leon, B.C, Muller-Deickmann, H.J, Nienaber, V.L, Noland, B.W, Post, K, Rajashankar, K.R, Ramos, A, Russell, M, Burley, S.K, Buchanan, S.G.
登録日2004-08-30
公開日2004-11-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase
J.Biol.Chem., 279, 2004

 

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