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4LM2

Crystal structure of PDE10A2 with fragment ZT462

Summary for 4LM2
Entry DOI10.2210/pdb4lm2/pdb
Related4LKQ 4LLJ 4LLL 4LLP 4LLX 4LM0 4LM1 4LM3 4LM4
DescriptorcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 2,3-dihydro-1,4-benzodioxin-6-ylmethanol, NICKEL (II) ION, ... (4 entities in total)
Functional Keywordsfragment screening, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: Q9Y233
Total number of polymer chains2
Total formula weight79359.43
Authors
Sridhar, V.,Badger, J.,Logan, C.,Chie-Leon, B.,Nienaber, V. (deposition date: 2013-07-09, release date: 2014-02-26, Last modification date: 2023-09-20)
Primary citationRecht, M.I.,Sridhar, V.,Badger, J.,Bounaud, P.Y.,Logan, C.,Chie-Leon, B.,Nienaber, V.,Torres, F.E.
Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
J Biomol Screen, 19:497-507, 2014
Cited by
PubMed: 24375910
DOI: 10.1177/1087057113516493
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.55 Å)
Structure validation

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