4TT7
Crystal structure of human ALK with a covalent modification
Summary for 4TT7
Entry DOI | 10.2210/pdb4tt7/pdb |
Descriptor | ALK tyrosine kinase receptor, 1-THIOETHANESULFONIC ACID, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | atp-binding, receptor, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : Q9UM73 |
Total number of polymer chains | 1 |
Total formula weight | 37240.79 |
Authors | Badger, J.,Sridhar, V.,Chie-Leon, B.,Nienaber, V.L.,Hausheer, F.H. (deposition date: 2014-06-19, release date: 2015-02-11, Last modification date: 2023-09-27) |
Primary citation | Parker, A.R.,Petluru, P.N.,Nienaber, V.L.,Zhao, M.,Ayala, P.Y.,Badger, J.,Chie-Leon, B.,Sridhar, V.,Logan, C.,Kochat, H.,Hausheer, F.H. Novel covalent modification of human anaplastic lymphoma kinase (ALK) and potentiation of crizotinib-mediated inhibition of ALK activity by BNP7787. Onco Targets Ther, 8:375-383, 2015 Cited by PubMed: 25678804DOI: 10.2147/OTT.S73690 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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