3L82
 
 | | X-ray Crystal structure of TRF1 and Fbx4 complex | | 分子名称: | F-box only protein 4, Telomeric repeat-binding factor 1 | | 著者 | Zeng, Z.X, Wang, W, Yang, Y.T, Chen, Y, Yang, X.M, Diehl, J.A, Liu, X.D, Lei, M. | | 登録日 | 2009-12-29 | | 公開日 | 2010-03-09 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural Basis of Selective Ubiquitination of TRF1 by SCF(Fbx4)
Dev.Cell, 18, 2010
|
|
4GM8
 | | Crystal structure of human WD repeat domain 5 with compound MM-102 | | 分子名称: | MM-102, WD repeat-containing protein 5 | | 著者 | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. | | 登録日 | 2012-08-15 | | 公開日 | 2013-07-31 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | | 主引用文献 | High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J.Am.Chem.Soc., 135, 2013
|
|
5H65
 | | Crystal structure of human POT1 and TPP1 | | 分子名称: | Adrenocortical dysplasia protein homolog, Protection of telomeres protein 1, ZINC ION | | 著者 | Chen, C, Wu, J, Lei, M. | | 登録日 | 2016-11-10 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.
Nat Commun, 8, 2017
|
|
4GM3
 | | Crystal structure of human WD repeat domain 5 with compound MM-101 | | 分子名称: | MM-101, WD repeat-containing protein 5 | | 著者 | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. | | 登録日 | 2012-08-15 | | 公開日 | 2013-07-31 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.393 Å) | | 主引用文献 | High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J.Am.Chem.Soc., 135, 2013
|
|
3KF8
 | | Crystal structure of C. tropicalis Stn1-ten1 complex | | 分子名称: | Protein stn1, Protein ten1 | | 著者 | Sun, J, Yu, E.Y, Yang, Y.T, Confer, L.A, Sun, S.H, Wan, K, Lue, N.F, Lei, M. | | 登録日 | 2009-10-27 | | 公開日 | 2009-12-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Genes Dev., 23, 2009
|
|
6MLC
 | | PHD6 domain of MLL3 in complex with histone H4 | | 分子名称: | GLYCEROL, Histone H4, Histone-lysine N-methyltransferase 2C, ... | | 著者 | Dong, A, Liu, Y, Qin, S, Lei, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2018-09-27 | | 公開日 | 2018-10-24 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.
Nat Commun, 10, 2019
|
|
2I46
 | | Crystal structure of human TPP1 | | 分子名称: | Adrenocortical dysplasia protein homolog | | 著者 | Wang, F, Podell, E.R, Zaug, A.J, Yang, Y.T, Baciu, P, Else, T, Hammer, G.D, Cech, T.R, Lei, M. | | 登録日 | 2006-08-21 | | 公開日 | 2006-11-28 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The POT1-TPP1 telomere complex is a telomerase processivity factor.
Nature, 445, 2007
|
|
3NBI
 | | Crystal structure of human RMI1 N-terminus | | 分子名称: | RecQ-mediated genome instability protein 1 | | 著者 | Wang, F, Yang, Y, Singh, T.R, Busygina, V, Guo, R, Wan, K, Wang, W, Sung, P, Meetei, A.R, Lei, M. | | 登録日 | 2010-06-03 | | 公開日 | 2010-09-22 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structures of RMI1 and RMI2, Two OB-Fold Regulatory Subunits of the BLM Complex.
Structure, 18, 2010
|
|
4GMB
 | | Crystal structure of human WD repeat domain 5 with compound MM-402 | | 分子名称: | MM-402, WD repeat-containing protein 5 | | 著者 | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. | | 登録日 | 2012-08-15 | | 公開日 | 2014-02-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.781 Å) | | 主引用文献 | Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
J.Med.Chem., 60, 2017
|
|
3NBH
 | | Crystal structure of human RMI1C-RMI2 complex | | 分子名称: | RecQ-mediated genome instability protein 1, RecQ-mediated genome instability protein 2 | | 著者 | Wang, F, Yang, Y, Singh, T.R, Busygina, V, Guo, R, Wan, K, Wang, W, Sung, P, Meetei, A.R, Lei, M. | | 登録日 | 2010-06-03 | | 公開日 | 2010-09-22 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structures of RMI1 and RMI2, Two OB-Fold Regulatory Subunits of the BLM Complex.
Structure, 18, 2010
|
|
4GM9
 | | Crystal structure of human WD repeat domain 5 with compound MM-401 | | 分子名称: | MM-401, WD repeat-containing protein 5 | | 著者 | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Liu, L, Dou, Y, Lei, M, Wang, S. | | 登録日 | 2012-08-15 | | 公開日 | 2014-02-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of human WD repeat domain 5 with compound MM-401
To be Published
|
|
4I80
 | |
2L3N
 | | Solution structure of Rap1-Taz1 fusion protein | | 分子名称: | DNA-binding protein rap1,Telomere length regulator taz1 | | 著者 | Zhou, Z.R, Wang, F, Chen, Y, Lei, M, Hu, H. | | 登録日 | 2010-09-19 | | 公開日 | 2011-01-12 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.
Nat.Struct.Mol.Biol., 18, 2011
|
|
2HKO
 | | Crystal structure of LSD1 | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1 | | 著者 | Chen, Y, Yang, Y.T, Wang, F, Yanane, K, Zhang, Y, Lei, M. | | 登録日 | 2006-07-05 | | 公開日 | 2006-08-29 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of human histone lysine-specific demethylase 1 (LSD1).
Proc.Natl.Acad.Sci.Usa, 103, 2006
|
|
4ZMI
 | | Crystal structure of the Helical domain of S. pombe Taz1 | | 分子名称: | COBALT (II) ION, MAGNESIUM ION, Telomere length regulator taz1 | | 著者 | Deng, W, Wu, J, Wang, F, Lei, M. | | 登録日 | 2015-05-04 | | 公開日 | 2015-09-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Fission yeast telomere-binding protein Taz1 is a functional but not a structural counterpart of human TRF1 and TRF2.
Cell Res., 25, 2015
|
|
4ZMK
 | |
4ZOU
 | |
2SRC
 | | CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP | | 分子名称: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, TYROSINE-PROTEIN KINASE SRC | | 著者 | Xu, W, Doshi, A, Lei, M, Eck, M.J, Harrison, S.C. | | 登録日 | 1998-12-29 | | 公開日 | 1999-07-22 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal structures of c-Src reveal features of its autoinhibitory mechanism.
Mol.Cell, 3, 1999
|
|
5F6K
 | | Crystal structure of the MLL3-Ash2L-RbBP5 complex | | 分子名称: | Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Li, Y, Lei, M, Chen, Y. | | 登録日 | 2015-12-06 | | 公開日 | 2016-02-24 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.411 Å) | | 主引用文献 | Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
|
|
5DOI
 | | Crystal structure of Tetrahymena p45N and p19 | | 分子名称: | Telomerase associated protein p45, Telomerase-associated protein 19 | | 著者 | Wan, B, Tang, T, Wu, J, Lei, M. | | 登録日 | 2015-09-11 | | 公開日 | 2015-11-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex
Nat.Struct.Mol.Biol., 22, 2015
|
|
5DOF
 | |
5DOK
 | | Crystal structure of Tetrahymena p45C | | 分子名称: | MAGNESIUM ION, Telomerase associated protein p45 | | 著者 | Wan, B, Tang, T, Wu, J, Lei, M. | | 登録日 | 2015-09-11 | | 公開日 | 2015-11-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex
Nat.Struct.Mol.Biol., 22, 2015
|
|
4M7C
 | | Crystal structure of the TRF2-binding motif of SLX4 in complex with the TRFH domain of TRF2 | | 分子名称: | Peptide from Structure-specific endonuclease subunit SLX4, Telomeric repeat-binding factor 2 | | 著者 | Wan, B, Chen, Y, Wu, J, Liu, Y, Lei, M. | | 登録日 | 2013-08-12 | | 公開日 | 2013-09-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres
Cell Rep, 4, 2013
|
|
4O26
 | |
5F59
 | | The crystal structure of MLL3 SET domain | | 分子名称: | Histone-lysine N-methyltransferase 2C, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | | 著者 | Li, Y, Lei, M, Chen, Y. | | 登録日 | 2015-12-04 | | 公開日 | 2016-02-24 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.801 Å) | | 主引用文献 | Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
|
|
