4A98
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![BU of 4a98 by Molmil](/molmil-images/mine/4a98) | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with bromoflurazepam | 分子名称: | 7-BROMO-1-[2-(DIETHYLAMINO)ETHYL]-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE, CYS-LOOP LIGAND-GATED ION CHANNEL | 著者 | Spurny, R, Brams, M, Nury, H, Legrand, P, Ulens, C. | 登録日 | 2011-11-24 | 公開日 | 2012-10-17 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.61 Å) | 主引用文献 | Pentameric Ligand-Gated Ion Channel Elic is Activated by Gaba and Modulated by Benzodiazepines. Proc.Natl.Acad.Sci.USA, 109, 2012
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5OLL
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![BU of 5oll by Molmil](/molmil-images/mine/5oll) | Crystal structure of gurmarin, a sweet taste suppressing polypeptide | 分子名称: | Gurmarin, NICKEL (II) ION | 著者 | Sigoillot, M, Neiers, F, Legrand, P, Roblin, P, Briand, L. | 登録日 | 2017-07-28 | 公開日 | 2018-08-08 | 最終更新日 | 2019-02-20 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | The Crystal Structure of Gurmarin, a Sweet Taste-Suppressing Protein: Identification of the Amino Acid Residues Essential for Inhibition. Chem. Senses, 43, 2018
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6ERG
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![BU of 6erg by Molmil](/molmil-images/mine/6erg) | Complex of XLF and heterodimer Ku bound to DNA | 分子名称: | DNA (21-MER), DNA (34-MER), Non-homologous end-joining factor 1, ... | 著者 | Nemoz, C, Legrand, P, Ropars, V, Charbonnier, J.B. | 登録日 | 2017-10-18 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining. Nat. Struct. Mol. Biol., 25, 2018
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6ERH
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![BU of 6erh by Molmil](/molmil-images/mine/6erh) | Complex of XLF and heterodimer Ku bound to DNA | 分子名称: | DNA (21-MER), DNA (34-MER), Non-homologous end-joining factor 1, ... | 著者 | Nemoz, C, Legrand, P, Ropars, V, Charbonnier, J.B. | 登録日 | 2017-10-18 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining. Nat. Struct. Mol. Biol., 25, 2018
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7QBS
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![BU of 7qbs by Molmil](/molmil-images/mine/7qbs) | B12-dependent radical SAM methyltransferase, Mmp10 with [4Fe-4S] cluster, cobalamin, S-adenosyl-L-methionine, and peptide bound. | 分子名称: | CO-METHYLCOBALAMIN, FE (III) ION, IRON/SULFUR CLUSTER, ... | 著者 | Bernardo-Garcia, N, Fyfe, C.D, Chavas, L.M.G, Legrand, P, Benjdia, A, Berteau, O. | 登録日 | 2021-11-19 | 公開日 | 2022-02-02 | 最終更新日 | 2022-02-23 | 実験手法 | X-RAY DIFFRACTION (2.327 Å) | 主引用文献 | Crystallographic snapshots of a B 12 -dependent radical SAM methyltransferase. Nature, 602, 2022
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6Y1X
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![BU of 6y1x by Molmil](/molmil-images/mine/6y1x) | X-ray structure of the radical SAM protein NifB, a key nitrogenase maturating enzyme | 分子名称: | CHLORIDE ION, IRON/SULFUR CLUSTER, Radical SAM domain protein, ... | 著者 | Sosa-Fajardo, A, Legrand, P, Paya-Tormo, L, Martin, L, Pellicer-Martinez, M.T, Echavarri-Erasun, C, Vernede, X, Rubio, L.M, Nicolet, Y. | 登録日 | 2020-02-14 | 公開日 | 2020-06-17 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural Insights into the Mechanism of the Radical SAM Carbide Synthase NifB, a Key Nitrogenase Cofactor Maturating Enzyme. J.Am.Chem.Soc., 142, 2020
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7B0H
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![BU of 7b0h by Molmil](/molmil-images/mine/7b0h) | TgoT_6G12 Ternary complex | 分子名称: | DNA (5'-D(P*AP*AP*CP*GP*GP*CP*AP*AP*AP*TP*GP*CP*G)-3'), DNA (5'-D(P*CP*GP*CP*AP*TP*T)-3'), DNA polymerase, ... | 著者 | Samson, C, Legrand, P, Tekpinar, M, Rozenski, J, Abramov, M, Holliger, P, Pinheiro, V, Herdewijn, P, Delarue, M. | 登録日 | 2020-11-19 | 公開日 | 2021-01-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution. Biomolecules, 10, 2020
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7B0F
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![BU of 7b0f by Molmil](/molmil-images/mine/7b0f) | TgoT_6G12 Binary complex | 分子名称: | DNA (5'-D(P*AP*AP*CP*GP*GP*CP*TP*AP*AP*TP*GP*CP*G)-3'), DNA (5'-D(P*CP*GP*CP*AP*TP*T)-3'), DNA polymerase, ... | 著者 | Samson, C, Legrand, P, Tekpinar, M, Rozenski, J, Abramov, M, Holliger, P, Pinheiro, V, Herdewijn, P, Delarue, M. | 登録日 | 2020-11-19 | 公開日 | 2020-12-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.797 Å) | 主引用文献 | Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution. Biomolecules, 10, 2020
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6ZA0
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![BU of 6za0 by Molmil](/molmil-images/mine/6za0) | Structure of the transcriptional repressor Atu1419 (VanR) in complex with a fortuitous citrate from agrobacterium fabrum (P21212 space group) | 分子名称: | 1,2-ETHANEDIOL, CITRIC ACID, DI(HYDROXYETHYL)ETHER, ... | 著者 | Morera, S, Vigouroux, A, Legrand, P. | 登録日 | 2020-06-04 | 公開日 | 2020-12-02 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Characterization of the first tetrameric transcription factor of the GntR superfamily with allosteric regulation from the bacterial pathogen Agrobacterium fabrum. Nucleic Acids Res., 49, 2021
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3ZVY
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![BU of 3zvy by Molmil](/molmil-images/mine/3zvy) | PHD finger of human UHRF1 in complex with unmodified histone H3 N- terminal tail | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, E3 UBIQUITIN-PROTEIN LIGASE UHRF1, ... | 著者 | Lallous, N, Birck, C, Mc Ewen, A.G, Legrand, P, Samama, J.P. | 登録日 | 2011-07-28 | 公開日 | 2011-12-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The Phd Finger of Human Uhrf1 Reveals a New Subgroup of Unmethylated Histone H3 Tail Readers. Plos One, 6, 2011
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1Q13
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![BU of 1q13 by Molmil](/molmil-images/mine/1q13) | Crystal structure of rabbit 20alpha hyroxysteroid dehydrogenase in ternary complex with NADP and testosterone | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Prostaglandin-E2 9-reductase, SULFATE ION, ... | 著者 | Couture, J.-F, Cantin, L, Legrand, P, Luu-The, V, Labrie, F, Breton, R. | 登録日 | 2003-07-18 | 公開日 | 2004-11-16 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily. J. Mol. Biol., 339, 2004
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8BHD
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![BU of 8bhd by Molmil](/molmil-images/mine/8bhd) | N-terminal domain of Plasmodium berghei glutamyl-tRNA synthetase (Tbxo4 derivative crystal structure) | 分子名称: | GLYCEROL, Glutamate--tRNA ligase, SULFATE ION, ... | 著者 | Benas, P, Jaramillo Ponce, J.R, Legrand, P, Frugier, M, Sauter, C. | 登録日 | 2022-10-31 | 公開日 | 2023-01-25 | 最終更新日 | 2023-02-08 | 実験手法 | X-RAY DIFFRACTION (3.17 Å) | 主引用文献 | Solution X-ray scattering highlights discrepancies in Plasmodium multi-aminoacyl-tRNA synthetase complexes. Protein Sci., 32, 2023
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1Q5M
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![BU of 1q5m by Molmil](/molmil-images/mine/1q5m) | Binary complex of rabbit 20alpha-hydroxysteroid dehydrogenase with NADPH | 分子名称: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Prostaglandin-E2 9-reductase, SULFATE ION | 著者 | Couture, J.F, Legrand, P, Cantin, L, Labrie, F, Luu-The, V, Breton, R. | 登録日 | 2003-08-08 | 公開日 | 2004-05-18 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | Loop Relaxation, A Mechanism that Explains the Reduced Specificity of Rabbit 20alpha-Hydroxysteroid Dehydrogenase, A Member of the Aldo-Keto Reductase Superfamily. J.Mol.Biol., 339, 2004
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5MJU
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![BU of 5mju by Molmil](/molmil-images/mine/5mju) | Structure of the thermostabilized EAAT1 cryst mutant in complex with the competititve inhibitor TFB-TBOA and the allosteric inhibitor UCPH101 | 分子名称: | (2~{S},3~{S})-2-azanyl-3-[[3-[[4-(trifluoromethyl)phenyl]carbonylamino]phenyl]methoxy]butanedioic acid, 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile, Excitatory amino acid transporter 1,Neutral amino acid transporter B(0),Excitatory amino acid transporter 1 | 著者 | Canul-Tec, J, Assal, R, Legrand, P, Reyes, N. | 登録日 | 2016-12-01 | 公開日 | 2017-04-19 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.71 Å) | 主引用文献 | Structure and allosteric inhibition of excitatory amino acid transporter 1. Nature, 544, 2017
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5MWN
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![BU of 5mwn by Molmil](/molmil-images/mine/5mwn) | Structure of the EAEC T6SS component TssK N-terminal domain in complex with llama nanobodies nbK18 and nbK27 | 分子名称: | PHOSPHATE ION, Type VI secretion protein, llama nanobody raised against TssK, ... | 著者 | Cambillau, C, Nguyen, V.S, Spinelli, S, Legrand, P. | 登録日 | 2017-01-18 | 公開日 | 2017-06-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex. Nat Microbiol, 2, 2017
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7B08
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![BU of 7b08 by Molmil](/molmil-images/mine/7b08) | TgoT apo | 分子名称: | DNA polymerase, THYMIDINE-5'-TRIPHOSPHATE, TRIETHYLENE GLYCOL | 著者 | Samson, C, Legrand, P, Tekpinar, M, Rozenski, J, Abramov, M, Holliger, P, Pinheiro, V, Herdewijn, P, Delarue, M. | 登録日 | 2020-11-18 | 公開日 | 2020-12-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.394 Å) | 主引用文献 | Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution. Biomolecules, 10, 2020
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7B07
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![BU of 7b07 by Molmil](/molmil-images/mine/7b07) | TgoT_6G12 apo | 分子名称: | CALCIUM ION, DNA polymerase | 著者 | Samson, C, Legrand, P, Tekpinar, M, Rozenski, J, Abramov, M, Holliger, P, Pinheiro, V, Herdewijn, P, Delarue, M. | 登録日 | 2020-11-18 | 公開日 | 2020-12-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.099 Å) | 主引用文献 | Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution. Biomolecules, 10, 2020
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7B06
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![BU of 7b06 by Molmil](/molmil-images/mine/7b06) | TgoT_RT521 apo | 分子名称: | DNA polymerase | 著者 | Samson, C, Legrand, P, Tekpinar, M, Rozenski, J, Abramov, M, Holliger, P, Pinheiro, V, Herdewijn, P, Delarue, M. | 登録日 | 2020-11-18 | 公開日 | 2020-12-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.349 Å) | 主引用文献 | Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution. Biomolecules, 10, 2020
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5LLM
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![BU of 5llm by Molmil](/molmil-images/mine/5llm) | Structure of the thermostabilized EAAT1 cryst mutant in complex with L-ASP and the allosteric inhibitor UCPH101 | 分子名称: | 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile, ASPARTIC ACID, Excitatory amino acid transporter 1,Neutral amino acid transporter B(0),Excitatory amino acid transporter 1, ... | 著者 | Canul-Tec, J, Assal, R, Legrand, P, Reyes, N. | 登録日 | 2016-07-27 | 公開日 | 2017-04-19 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Structure and allosteric inhibition of excitatory amino acid transporter 1. Nature, 544, 2017
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5MKO
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![BU of 5mko by Molmil](/molmil-images/mine/5mko) | [2Fe-2S] cluster containing TtuA in complex with AMP. | 分子名称: | ADENOSINE MONOPHOSPHATE, FE2/S2 (INORGANIC) CLUSTER, TtuA PH0300, ... | 著者 | Arragain, S, Bimai, O, Legrand, P, Golinelli-Pimpaneau, B. | 登録日 | 2016-12-05 | 公開日 | 2017-06-14 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Nonredox thiolation in tRNA occurring via sulfur activation by a [4Fe-4S] cluster. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3ZVZ
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![BU of 3zvz by Molmil](/molmil-images/mine/3zvz) | PHD finger of human UHRF1 | 分子名称: | E3 UBIQUITIN-PROTEIN LIGASE UHRF1, ZINC ION | 著者 | Lallous, N, Birck, C, Mc Ewen, A.G, Legrand, P, Samama, J.P. | 登録日 | 2011-07-28 | 公開日 | 2011-11-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.449 Å) | 主引用文献 | The Phd Finger of Human Uhrf1 Reveals a New Subgroup of Unmethylated Histone H3 Tail Readers. Plos One, 6, 2011
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6FI9
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![BU of 6fi9 by Molmil](/molmil-images/mine/6fi9) | |
2X78
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![BU of 2x78 by Molmil](/molmil-images/mine/2x78) | Human foamy virus integrase - catalytic core. | 分子名称: | INTEGRASE | 著者 | Rety, S, Delelis, O, Rezabkova, L, Dubanchet, B, Legrand, P, Silhan, J, Lewit-Bentley, A. | 登録日 | 2010-02-24 | 公開日 | 2010-08-11 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Studies of the Catalytic Core of the Primate Foamy Virus (Pfv-1) Integrase Acta Crystallogr.,Sect.F, 66, 2010
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7ATH
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![BU of 7ath by Molmil](/molmil-images/mine/7ath) | Crystal structure of UipA | 分子名称: | UipA, ZINC ION | 著者 | Bremond, N, Gallois, N, Legrand, P, Chapon, V, Arnoux, P. | 登録日 | 2020-10-30 | 公開日 | 2021-10-06 | 最終更新日 | 2022-03-02 | 実験手法 | X-RAY DIFFRACTION (2.343 Å) | 主引用文献 | Discovery and characterization of UipA, a uranium- and iron-binding PepSY protein involved in uranium tolerance by soil bacteria. Isme J, 16, 2022
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7ATK
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![BU of 7atk by Molmil](/molmil-images/mine/7atk) | Crystal structure of UipA in complex with Uranium | 分子名称: | URANIUM ATOM, UipA, ZINC ION | 著者 | Bremond, N, Gallois, N, Legrand, P, Chapon, V, Arnoux, P. | 登録日 | 2020-10-30 | 公開日 | 2021-10-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.855 Å) | 主引用文献 | Discovery and characterization of UipA, a uranium- and iron-binding PepSY protein involved in uranium tolerance by soil bacteria. Isme J, 16, 2022
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