5MJU

Structure of the thermostabilized EAAT1 cryst mutant in complex with the competititve inhibitor TFB-TBOA and the allosteric inhibitor UCPH101

Summary for 5MJU

Entry DOI	10.2210/pdb5mju/pdb
Descriptor	Excitatory amino acid transporter 1,Neutral amino acid transporter B(0),Excitatory amino acid transporter 1, 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile, (2~{S},3~{S})-2-azanyl-3-[[3-[[4-(trifluoromethyl)phenyl]carbonylamino]phenyl]methoxy]butanedioic acid (3 entities in total)
Functional Keywords	excitatory aminoacid transporter 1, human glutamate transporter, tfb-tboa, ucph-101, transport protein
Biological source	Homo sapiens (Human) More
Cellular location	Membrane; Multi-pass membrane protein: P43003
Total number of polymer chains	1
Total formula weight	57361.20
Authors	Canul-Tec, J.,Assal, R.,Legrand, P.,Reyes, N. (deposition date: 2016-12-01, release date: 2017-04-19, Last modification date: 2024-01-17)
Primary citation	Canul-Tec, J.C.,Assal, R.,Cirri, E.,Legrand, P.,Brier, S.,Chamot-Rooke, J.,Reyes, N. Structure and allosteric inhibition of excitatory amino acid transporter 1. Nature, 544:446-451, 2017 Cited by PubMed: 28424515 DOI: 10.1038/nature22064 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.71 Å)

Structure validation