6U6B
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![BU of 6u6b by Molmil](/molmil-images/mine/6u6b) | Structure of human DNA polymerase beta misinserting dAMPNPP opposite the 5'G of the cisplatin Pt-GG intrastrand crosslink with Manganese in the active site | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Cisplatin, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), ... | Authors: | Ouzon-Shubeita, H, Vilas, C.K, Lee, S. | Deposit date: | 2019-08-29 | Release date: | 2020-09-09 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.108 Å) | Cite: | Structural insights into the promutagenic bypass of the major cisplatin-induced DNA lesion. Biochem.J., 477, 2020
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6U2O
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![BU of 6u2o by Molmil](/molmil-images/mine/6u2o) | |
6UQI
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![BU of 6uqi by Molmil](/molmil-images/mine/6uqi) | |
6UOS
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![BU of 6uos by Molmil](/molmil-images/mine/6uos) | |
6UOW
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![BU of 6uow by Molmil](/molmil-images/mine/6uow) | |
6UOP
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![BU of 6uop by Molmil](/molmil-images/mine/6uop) | |
6UOR
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![BU of 6uor by Molmil](/molmil-images/mine/6uor) | |
6UOU
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![BU of 6uou by Molmil](/molmil-images/mine/6uou) | |
6UOQ
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![BU of 6uoq by Molmil](/molmil-images/mine/6uoq) | |
6V5K
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![BU of 6v5k by Molmil](/molmil-images/mine/6v5k) | |
6VG6
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![BU of 6vg6 by Molmil](/molmil-images/mine/6vg6) | Crystal structure of DPO4 with 8-oxoadenine (oxoA) and dGTP* | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*C)-3'), DNA (5'-D(*TP*CP*AP*TP*(A38)P*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), ... | Authors: | Jung, H, Lee, S. | Deposit date: | 2020-01-07 | Release date: | 2021-01-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.08 Å) | Cite: | Promutagenic bypass of 7,8-dihydro-8-oxoadenine by translesion synthesis DNA polymerase Dpo4. Biochem.J., 477, 2020
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6VGM
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![BU of 6vgm by Molmil](/molmil-images/mine/6vgm) | Crystal structure of DPO4 with 8-oxoadenine (oxoA) and dTTP* | Descriptor: | 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*C)-3'), DNA (5'-D(*TP*CP*AP*TP*(A38)P*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), ... | Authors: | Jung, H, Lee, S. | Deposit date: | 2020-01-08 | Release date: | 2021-01-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Promutagenic bypass of 7,8-dihydro-8-oxoadenine by translesion synthesis DNA polymerase Dpo4. Biochem.J., 477, 2020
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6VNP
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![BU of 6vnp by Molmil](/molmil-images/mine/6vnp) | Crystal structure of DPO4 extension past 8-oxoadenine (oxoA) and dT | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*TP*TP*CP*AP*T*(R5M)P*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*CP*T)-3'), ... | Authors: | Jung, H, Lee, S. | Deposit date: | 2020-01-29 | Release date: | 2021-02-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Crystal structure of DPO4 extension past 8-oxoadenine (oxoA) and dT To Be Published
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6UI2
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![BU of 6ui2 by Molmil](/molmil-images/mine/6ui2) | |
6W5X
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![BU of 6w5x by Molmil](/molmil-images/mine/6w5x) | Crystal structure of human polymerase eta complexed with N7-benzylguanine and dCTP* | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*TP*(DRG)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), ... | Authors: | Jung, H, Lee, S. | Deposit date: | 2020-03-14 | Release date: | 2021-03-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Crystal structure of human polymerase eta complexed with N7-benzylguanine and dCTP* To Be Published
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4YPR
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![BU of 4ypr by Molmil](/molmil-images/mine/4ypr) | Crystal Structure of D144N MutY bound to its anti-substrate | Descriptor: | A/G-specific adenine glycosylase, DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3'), DNA (5'-D(*T*GP*TP*CP*CP*AP*CP*GP*TP*CP*T)-3'), ... | Authors: | Wang, L, Lee, S, Verdine, G.L. | Deposit date: | 2015-03-13 | Release date: | 2015-05-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase. J.Biol.Chem., 290, 2015
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6WK6
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![BU of 6wk6 by Molmil](/molmil-images/mine/6wk6) | Crystal structure of human polymerase eta complexed with Xanthine containing DNA | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*TP*(3ZO)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), ... | Authors: | Jung, H, Lee, S. | Deposit date: | 2020-04-15 | Release date: | 2021-01-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase. Biochem.J., 477, 2020
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6VKP
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![BU of 6vkp by Molmil](/molmil-images/mine/6vkp) | Crystal structure of DPO4 extension past 8-oxoadenine (oxoA) and dG | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*GP*GP*GP*GP*GP*AP*AP*AP*GP*AP*TP*TP*CP*G)-3'), DNA (5'-D(*TP*TP*CP*AP*TP*(A38)P*GP*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*CP*C)-3'), ... | Authors: | Jung, H, Lee, S. | Deposit date: | 2020-01-21 | Release date: | 2021-01-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Insights into the mismatch discrimination mechanism of Y-family DNA polymerase Dpo4. Biochem.J., 478, 2021
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4H58
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![BU of 4h58 by Molmil](/molmil-images/mine/4h58) | BRAF in complex with compound 3 | Descriptor: | CHLORIDE ION, N-(4-{[(2-methoxyethyl)amino]methyl}phenyl)-6-(pyridin-4-yl)quinazolin-2-amine, Serine/threonine-protein kinase B-raf | Authors: | Vasbinder, M, Aquila, B, Augustin, M, Chueng, T, Cook, D, Drew, L, Fauber, B, Glossop, S, Godin, R, Grondine, M, Hennessy, E, Johannes, J, Lee, S, Lyne, P, Moertl, M, Omer, C, Palakurthi, S, Pontz, T, Read, J, Sha, L, Shen, M, Steinbacher, S, Wang, H, Wu, A, Ye, M, Bagal, B. | Deposit date: | 2012-09-18 | Release date: | 2013-02-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Discovery and Optimization of a Novel Series of Potent Mutant B-Raf(V600E) Selective Kinase Inhibitors. J.Med.Chem., 56, 2013
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6PL8
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3CW7
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![BU of 3cw7 by Molmil](/molmil-images/mine/3cw7) | Crystal Structure of an AlkA Host/Guest Complex 8oxoGuanine:Cytosine Base Pair | Descriptor: | DNA (5'-D(*DGP*DAP*DCP*DAP*DTP*DGP*DAP*(8OG)P*DTP*DGP*DCP*DC)-3'), DNA (5'-D(*DGP*DGP*DCP*DAP*DCP*DTP*DCP*DAP*DTP*DGP*DTP*DC)-3'), DNA-3-methyladenine glycosylase 2 | Authors: | Bowman, B.R, Lee, S, Wang, S, Verdine, G.L. | Deposit date: | 2008-04-21 | Release date: | 2008-09-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the E. coli DNA Glycosylase AlkA Bound to the Ends of Duplex DNA: A System for the Structure Determination of Lesion-Containing DNA. Structure, 16, 2008
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3CWT
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![BU of 3cwt by Molmil](/molmil-images/mine/3cwt) | Crystal Structure of an AlkA Host/Guest Complex 2'-fluoro-2'-deoxyinosine:Adenine Base Pair | Descriptor: | DNA (5'-D(*DGP*DAP*DCP*DAP*DTP*DGP*DAP*(2FI)P*DTP*DGP*DCP*DC)-3'), DNA (5'-D(*DGP*DGP*DCP*DAP*DAP*DTP*DCP*DAP*DTP*DGP*DTP*DC)-3'), DNA-3-methyladenine glycosylase 2 | Authors: | Bowman, B.R, Lee, S, Wang, S, Verdine, G.L. | Deposit date: | 2008-04-22 | Release date: | 2008-09-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the E. coli DNA Glycosylase AlkA Bound to the Ends of Duplex DNA: A System for the Structure Determination of Lesion-Containing DNA. Structure, 16, 2008
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5IS1
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![BU of 5is1 by Molmil](/molmil-images/mine/5is1) | |
4ICQ
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![BU of 4icq by Molmil](/molmil-images/mine/4icq) | |
6PLC
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![BU of 6plc by Molmil](/molmil-images/mine/6plc) | |