2W80
 
 | | Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H | | Descriptor: | COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN | | Authors: | Schneider, M.C, Prosser, B.E, Caesar, J.J.E, Kugelberg, E, Li, S, Zhang, Q, Quoraishi, S, Lovett, J.E, Deane, J.E, Sim, R.B, Roversi, P, Johnson, S, Tang, C.M, Lea, S.M. | | Deposit date: | 2009-01-08 | | Release date: | 2009-03-03 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Neisseria Meningitidis Recruits Factor H Using Protein Mimicry of Host Carbohydrates.
Nature, 458, 2009
|
|
4AQB
 | | MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44 | | Descriptor: | CALCIUM ION, MANNAN-BINDING LECTIN SERINE PROTEASE 1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Skjoedt, M.O, Roversi, P, Hummelshoj, T, Palarasah, Y, Johnson, S, Lea, S.M, Garred, P. | | Deposit date: | 2012-04-16 | | Release date: | 2012-08-08 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | Crystal Structure and Functional Characterization of the Complement Regulator Mannose-Binding Lectin (Mbl)/Ficolin-Associated Protein-1 (Map-1).
J.Biol.Chem., 287, 2012
|
|
4A9X
 | | Pseudomonas fluorescens PhoX in complex with the substrate analogue AppCp | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, MU-OXO-DIIRON, ... | | Authors: | Yong, S.C, Roversi, P, Lillington, J.E.D, Zeldin, O.B, Garman, E.F, Lea, S.M, Berks, B.C. | | Deposit date: | 2011-11-29 | | Release date: | 2012-12-05 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | A Complex Iron-Calcium Cofactor Catalyzing Phosphotransfer Chemistry
Science, 345, 2014
|
|
6RQJ
 | | Structure of human complement C5 complexed with tick inhibitors OmCI, RaCI1 and CirpT1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5, Complement inhibitor, ... | | Authors: | Reichhardt, M.P, Johnson, S, Lea, S.M. | | Deposit date: | 2019-05-15 | | Release date: | 2020-01-08 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | An inhibitor of complement C5 provides structural insights into activation.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
4TT9
 | |
6RPT
 | |
2YF2
 | |
6SAN
 | | SALSA / DMBT1 / GP340 SRCR domain 8 soaked in calcium and magnesium | | Descriptor: | CHLORIDE ION, Deleted in malignant brain tumors 1 protein, GLYCEROL, ... | | Authors: | Reichhardt, M.P, Johnson, S, Loimaranta, V, Lea, S.M. | | Deposit date: | 2019-07-17 | | Release date: | 2020-03-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.36 Å) | | Cite: | Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold.
Life Sci Alliance, 3, 2020
|
|
5NQY
 | | Structure of a fHbp(V1.4):PorA(P1.16) chimera. Fusion at fHbp position 309. | | Descriptor: | Factor H binding protein variant B16_001,Major outer membrane protein P.IA,Factor H binding protein variant B16_001 | | Authors: | Johnson, S, Hollingshead, S, Lea, S.M, Tang, C.M. | | Deposit date: | 2017-04-21 | | Release date: | 2018-02-28 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure-based design of chimeric antigens for multivalent protein vaccines.
Nat Commun, 9, 2018
|
|
6SA4
 | | SALSA / DMBT1 / GP340 SRCR domain 1 | | Descriptor: | CHLORIDE ION, Deleted in malignant brain tumors 1 protein, GLYCEROL, ... | | Authors: | Reichhardt, M.P, Lea, S.M, Johnson, S. | | Deposit date: | 2019-07-16 | | Release date: | 2020-03-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold.
Life Sci Alliance, 3, 2020
|
|
5NQX
 | | Structure of a fHbp(V1.1):PorA(P1.16) chimera. Fusion at fHbp position 294. | | Descriptor: | Factor H binding protein,Major outer membrane protein P.IA,Factor H binding protein | | Authors: | Johnson, S, Jongerius, I, Lea, S.M, Tang, C.M. | | Deposit date: | 2017-04-21 | | Release date: | 2018-02-28 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.66 Å) | | Cite: | Structure-based design of chimeric antigens for multivalent protein vaccines.
Nat Commun, 9, 2018
|
|
2VT1
 | | Crystal structure of the cytoplasmic domain of Spa40, the specificity switch for the Shigella flexneri Type III Secretion System | | Descriptor: | SURFACE PRESENTATION OF ANTIGENS PROTEIN SPAS | | Authors: | Deane, J.E, Graham, S.C, Mitchell, E.P, Flot, D, Johnson, S, Lea, S.M. | | Deposit date: | 2008-05-08 | | Release date: | 2008-05-20 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of Spa40, the Specificity Switch for the Shigella Flexneri Type III Secretion System
Mol.Microbiol., 69, 2008
|
|
4A5W
 | | Crystal structure of C5b6 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COMPLEMENT C5, ... | | Authors: | Hadders, M.A, Bubeck, D, Forneris, F, Pangburn, M, Llorca, O, Lea, S.M, Gros, P. | | Deposit date: | 2011-10-28 | | Release date: | 2012-03-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9.
Cell Rep., 1, 2012
|
|
5ACZ
 | | COMPLEX OF A B21 CHICKEN MHC CLASS I MOLECULE AND A 11MER CHICKEN PEPTIDE | | Descriptor: | 1,2-ETHANEDIOL, 11MER PEPTIDE, BETA-2-MICROGLOBULIN, ... | | Authors: | Chappell, P.E, Roversi, P, Harrison, M.C, Kaufman, J.F, Lea, S.M. | | Deposit date: | 2015-08-19 | | Release date: | 2016-09-28 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.69 Å) | | Cite: | Complex of a B21 Chicken Mhc Class I Molecule and a 11mer Chicken Peptide
To be Published
|
|
5AD0
 | | COMPLEX OF A B21 CHICKEN MHC CLASS I MOLECULE AND A 11MER CHICKEN PEPTIDE | | Descriptor: | 1,2-ETHANEDIOL, 11MER PEPTIDE, BETA-2-MICROGLOBULIN, ... | | Authors: | Chappell, P.E, Roversi, P, Harrison, M.C, Kaufman, J.F, Lea, S.M. | | Deposit date: | 2015-08-19 | | Release date: | 2016-09-28 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.84 Å) | | Cite: | Complex of a B21 Chicken Mhc Class I Molecule and a 11mer Chicken Peptide
To be Published
|
|
2UXT
 | | SufI Protein from Escherichia Coli | | Descriptor: | PROTEIN SUFI | | Authors: | Tarry, M.J, Roversi, P, Sargent, F, Berks, B.C, Lea, S.M. | | Deposit date: | 2007-03-29 | | Release date: | 2008-05-13 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The Escherichia Coli Cell Division Protein and Model Tat Substrate Sufi (Ftsp) Localizes to the Septal Ring and Has a Multicopper Oxidase-Like Structure.
J.Mol.Biol., 386, 2009
|
|
2UXV
 | | SufI Protein from Escherichia Coli | | Descriptor: | PROTEIN SUFI | | Authors: | Tarry, M.J, Roversi, P, Sargent, F, Berks, B.C, Lea, S.M. | | Deposit date: | 2007-03-30 | | Release date: | 2008-05-13 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.61 Å) | | Cite: | The Escherichia Coli Cell Division Protein and Model Tat Substrate Sufi (Ftsp) Localizes to the Septal Ring and Has a Multicopper Oxidase-Like Structure.
J.Mol.Biol., 386, 2009
|
|
5MWE
 | | Complex between the Leucine Zipper (LZ, residues 490-567) and Centrosomin-motif 2 (CM2) domains of Drosophila melanogaster Centrosomin (Cnn) | | Descriptor: | 1,2-ETHANEDIOL, 3,3',3''-phosphanetriyltripropanoic acid, Centrosomin, ... | | Authors: | Feng, Z, Johnson, S, Raff, J.W, Lea, S.M. | | Deposit date: | 2017-01-18 | | Release date: | 2017-06-28 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Structural Basis for Mitotic Centrosome Assembly in Flies.
Cell, 169, 2017
|
|
5MW9
 | | Complex between the Leucine Zipper (LZ) and Centrosomin-motif 2 (CM2) domains of Drosophila melanogaster Centrosomin (Cnn) - L535E mutant form | | Descriptor: | Centrosomin, ZINC ION | | Authors: | Feng, Z, Johnson, S, Raff, J.W, Lea, S.M. | | Deposit date: | 2017-01-18 | | Release date: | 2017-06-28 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural Basis for Mitotic Centrosome Assembly in Flies.
Cell, 169, 2017
|
|
5MVW
 | | Complex between the Leucine Zipper (LZ) and Centrosomin-motif 2 (CM2) domains of Drosophila melanogaster Centrosomin (Cnn) | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Centrosomin, ... | | Authors: | Feng, Z, Johnson, S, Raff, J.W, Lea, S.M. | | Deposit date: | 2017-01-17 | | Release date: | 2017-06-28 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Structural Basis for Mitotic Centrosome Assembly in Flies.
Cell, 169, 2017
|
|
5MW0
 | | Complex between the Leucine Zipper (LZ) and Centrosomin-motif 2 (CM2) domains of Drosophila melanogaster Centrosomin (Cnn) - L535E mutant form | | Descriptor: | Centrosomin, ZINC ION | | Authors: | Feng, Z, Johnson, S, Raff, J.W, Lea, S.M. | | Deposit date: | 2017-01-17 | | Release date: | 2017-06-28 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Basis for Mitotic Centrosome Assembly in Flies.
Cell, 169, 2017
|
|
2VJ4
 | | Methylated Shigella flexneri MxiC | | Descriptor: | PROTEIN MXIC | | Authors: | Deane, J.E, Roversi, P, King, C, Johnson, S, Lea, S.M. | | Deposit date: | 2007-12-06 | | Release date: | 2008-03-11 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structures of the Shigella Flexneri Type 3 Secretion System Protein Mxic Reveal Conformational Variability Amongst Homologues.
J.Mol.Biol., 377, 2008
|
|
2WDC
 | | Termus thermophilus Sulfate thiohydrolase SoxB in complex with glycerol | | Descriptor: | ACETATE ION, GLYCEROL, MANGANESE (II) ION, ... | | Authors: | Sauve, V, Roversi, P, Leath, K.J, Garman, E.F, Antrobus, R, Lea, S.M, Berks, B.C. | | Deposit date: | 2009-03-24 | | Release date: | 2009-06-16 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Mechanism for the Hydrolysis of a Sulfur-Sulfur Bond Based on the Crystal Structure of the Thiosulfohydrolase Soxb.
J.Biol.Chem., 284, 2009
|
|
5HCD
 | | Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus microplus RaCI2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, Complement C5, ... | | Authors: | Jore, M.M, Johnson, S, Lea, S.M. | | Deposit date: | 2016-01-04 | | Release date: | 2016-03-30 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.98 Å) | | Cite: | Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
|
|
2W5P
 | | DraE Adhesin in complex with Chloramphenicol Succinate (monoclinic form) | | Descriptor: | CHLORAMPHENICOL SUCCINATE, DR HEMAGGLUTININ STRUCTURAL SUBUNIT, SULFATE ION | | Authors: | Pettigrew, D.M, Roversi, P, Davies, S.G, Russell, A.J, Lea, S.M. | | Deposit date: | 2008-12-11 | | Release date: | 2009-06-02 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A Structural Study of the Interaction between the Dr Haemagglutinin Drae and Derivatives of Chloramphenicol
Acta Crystallogr.,Sect.D, 65, 2009
|
|
