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PDB: 152 件
5I4B
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Erwinia chrysanthemi L-asparaginase E63Q +S254N mutation + L-Aspartic acid
分子名称: ASPARTIC ACID, L-asparaginase
著者Nguyen, H.A, Lavie, A.
登録日2016-02-11
公開日2016-07-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Design and Characterization of Erwinia Chrysanthemi l-Asparaginase Variants with Diminished l-Glutaminase Activity.
J.Biol.Chem., 291, 2016
5I3Z
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BU of 5i3z by Molmil
Erwinia chrysanthemi L-asparaginase E63Q mutation + Aspartic acid
分子名称: ASPARTIC ACID, L-asparaginase
著者Nguyen, H.A, Lavie, A.
登録日2016-02-11
公開日2016-07-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Design and Characterization of Erwinia Chrysanthemi l-Asparaginase Variants with Diminished l-Glutaminase Activity.
J.Biol.Chem., 291, 2016
5I48
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Erwinia chrysanthemi L-asparaginase A31I + E63Q mutation + Aspartic acid
分子名称: ASPARTIC ACID, L-asparaginase
著者Nguyen, H.A, Lavie, A.
登録日2016-02-11
公開日2016-07-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Design and Characterization of Erwinia Chrysanthemi l-Asparaginase Variants with Diminished l-Glutaminase Activity.
J.Biol.Chem., 291, 2016
3TSV
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BU of 3tsv by Molmil
crystal structure of the third PDZ domain of the human ZO-1 MAGUK protein
分子名称: Tight junction protein ZO-1
著者Nomme, J, Lavie, A.
登録日2011-09-13
公開日2011-10-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.989 Å)
主引用文献The Src Homology 3 Domain Is Required for Junctional Adhesion Molecule Binding to the Third PDZ Domain of the Scaffolding Protein ZO-1.
J.Biol.Chem., 286, 2011
1P72
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BU of 1p72 by Molmil
Crystal structure of EHV4-TK complexed with Thy and ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, SULFATE ION, THYMIDINE, ...
著者Gardberg, A, Shuvalova, L, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2003-04-30
公開日2003-11-04
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1P73
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Crystal structure of EHV4-TK complexed with TP4A
分子名称: P1-(5'-ADENOSYL)P4-(5'-(2'-DEOXY-THYMIDYL))TETRAPHOSPHATE, SULFATE ION, Thymidine kinase
著者Gardberg, A, Shuvalova, L, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2003-04-30
公開日2003-11-04
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structure, 11, 2003
1P60
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Structure of human dCK complexed with 2'-Deoxycytidine and ADP, Space group C 2 2 21
分子名称: 2'-DEOXYCYTIDINE, ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase
著者Sabini, E, Ort, S, Monnerjahn, C, Konrad, M, Lavie, A.
登録日2003-04-28
公開日2003-07-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Structure of human dCK suggests strategies to improve anticancer and antiviral therapy
Nat.Struct.Biol., 10, 2003
2CKP
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BU of 2ckp by Molmil
Crystal structure of Human Choline Kinase alpha-2 in complex with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHOLINE KINASE ALPHA
著者Malito, E, Lavie, A.
登録日2006-04-20
公開日2006-10-04
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Elucidation of Human Choline Kinase Crystal Structures in Complex with the Products Adp or Phosphocholine.
J.Mol.Biol., 364, 2006
2CKO
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BU of 2cko by Molmil
Crystal structure of Human Choline Kinase alpha 2
分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHOLINE KINASE ALPHA
著者Malito, E, Lavie, A.
登録日2006-04-20
公開日2006-10-04
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Elucidation of Human Choline Kinase Crystal Structures in Complex with the Products Adp or Phosphocholine.
J.Mol.Biol., 364, 2006
2CKQ
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BU of 2ckq by Molmil
Crystal structure of Human Choline Kinase alpha 2 in complex with Phosphocholine
分子名称: CHOLINE KINASE ALPHA, PHOSPHOCHOLINE
著者Malito, E, Lavie, A.
登録日2006-04-20
公開日2006-10-04
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Elucidation of Human Choline Kinase Crystal Structures in Complex with the Products Adp or Phosphocholine.
J.Mol.Biol., 364, 2006
2HAZ
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BU of 2haz by Molmil
Crystal structure of the first fibronectin domain of human NCAM1
分子名称: Neural cell adhesion molecule 1, SODIUM ION
著者Sekulic, N, Lavie, A.
登録日2006-06-13
公開日2006-10-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A novel alpha-helix in the first fibronectin type III repeat of the neural cell adhesion molecule is critical for N-glycan polysialylation.
J.Biol.Chem., 281, 2006
1TEV
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BU of 1tev by Molmil
Crystal structure of the human UMP/CMP kinase in open conformation
分子名称: SULFATE ION, UMP-CMP kinase
著者Segura-Pena, D, Sekulic, N, Ort, S, Konrad, M, Lavie, A.
登録日2004-05-25
公開日2004-06-22
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Substrate-induced Conformational Changes in Human UMP/CMP Kinase.
J.Biol.Chem., 279, 2004
4GUJ
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BU of 4guj by Molmil
1.50 Angstrom Crystal Structure of the Salmonella enterica 3-Dehydroquinate Dehydratase (aroD) in Complex with Shikimate
分子名称: (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, 3-dehydroquinate dehydratase, ZINC ION
著者Light, S.H, Minasov, G, Duban, M.-E, Shuvalova, L, Kwon, K, Lavie, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2012-08-29
公開日2012-09-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structures of type I dehydroquinate dehydratase in complex with quinate and shikimate suggest a novel mechanism of schiff base formation.
Biochemistry, 53, 2014
4GUI
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1.78 Angstrom Crystal Structure of the Salmonella enterica 3-Dehydroquinate Dehydratase (aroD) in Complex with Quinate
分子名称: (1S,3R,4S,5R)-1,3,4,5-tetrahydroxycyclohexanecarboxylic acid, 3-dehydroquinate dehydratase, NICKEL (II) ION
著者Light, S.H, Minasov, G, Duban, M.-E, Shuvalova, L, Kwon, K, Lavie, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2012-08-29
公開日2012-09-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Crystal structures of type I dehydroquinate dehydratase in complex with quinate and shikimate suggest a novel mechanism of schiff base formation.
Biochemistry, 53, 2014
4JLK
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BU of 4jlk by Molmil
Human dCK C4S-S74E mutant in complex with UDP and the F2.2.1 inhibitoR (2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5-METHYL-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE)
分子名称: 2-[({2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol-4-yl}methyl)sulfanyl]pyrimidine-4,6-diamine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Nomme, J, Lavie, A.
登録日2013-03-12
公開日2013-09-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.
J.Med.Chem., 56, 2013
2ZI6
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C4S dCK variant of dCK in complex with D-dA+UDP
分子名称: (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Sabini, E, Lavie, A.
登録日2008-02-13
公開日2008-04-22
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Structural basis for substrate promiscuity of dCK
J.Mol.Biol., 378, 2008
4GUH
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BU of 4guh by Molmil
1.95 Angstrom Crystal Structure of the Salmonella enterica 3-Dehydroquinate Dehydratase (aroD) E86A Mutant in Complex with Dehydroshikimate (Crystal Form #2)
分子名称: (4S,5R)-4,5-dihydroxy-3-oxocyclohex-1-ene-1-carboxylic acid, 3-dehydroquinate dehydratase, NICKEL (II) ION
著者Light, S.H, Minasov, G, Duban, M.-E, Shuvalova, L, Kwon, K, Lavie, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2012-08-29
公開日2012-09-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Reassessing the type I dehydroquinate dehydratase catalytic triad: Kinetic and structural studies of Glu86 mutants.
Protein Sci., 22, 2013
4GUF
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1.5 Angstrom Crystal Structure of the Salmonella enterica 3-Dehydroquinate Dehydratase (aroD) E86A Mutant
分子名称: 3-dehydroquinate dehydratase, CHLORIDE ION
著者Light, S.H, Minasov, G, Duban, M.-E, Shuvalova, L, Kwon, K, Lavie, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2012-08-29
公開日2012-09-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Reassessing the type I dehydroquinate dehydratase catalytic triad: Kinetic and structural studies of Glu86 mutants.
Protein Sci., 22, 2013
4IUO
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1.8 Angstrom Crystal Structure of the Salmonella enterica 3-Dehydroquinate Dehydratase (aroD) K170M Mutant in Complex with Quinate
分子名称: (1S,3R,4S,5R)-1,3,4,5-tetrahydroxycyclohexanecarboxylic acid, 3-dehydroquinate dehydratase
著者Light, S.H, Minasov, G, Duban, M.-E, Shuvalova, L, Kwon, K, Lavie, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2013-01-21
公開日2013-01-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structures of type I dehydroquinate dehydratase in complex with quinate and shikimate suggest a novel mechanism of schiff base formation.
Biochemistry, 53, 2014
4KCG
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Human dCK C4S-S74E mutant in complex with UDP and the DI-39 inhibitor
分子名称: Deoxycytidine kinase, N-{2-[5-(4-{[(4,6-diaminopyrimidin-2-yl)sulfanyl]methyl}-5-propyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]ethyl}methanesulfonamide, URIDINE-5'-DIPHOSPHATE
著者Nomme, J, Lavie, A.
登録日2013-04-24
公開日2014-03-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.
J.Exp.Med., 211, 2014
4L5B
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Human dCK C4S-S74E mutant in complex with UDP and the DI-43 inhibitor
分子名称: 1-[5-(4-{[(4,6-diaminopyrimidin-2-yl)sulfanyl]methyl}-5-propyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]-2-methylpropan-2-ol, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Nomme, J, Lavie, A.
登録日2013-06-10
公開日2013-09-18
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.
J.Med.Chem., 56, 2013
3TSZ
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crystal structure of PDZ3-SH3-GUK core module from human ZO-1 in complex with 12mer peptide from human JAM-A cytoplasmic tail
分子名称: Junctional adhesion molecule A, Tight junction protein ZO-1
著者Nomme, J, Lavie, A.
登録日2011-09-13
公開日2011-10-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.502 Å)
主引用文献The Src Homology 3 Domain Is Required for Junctional Adhesion Molecule Binding to the Third PDZ Domain of the Scaffolding Protein ZO-1.
J.Biol.Chem., 286, 2011
4GUG
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BU of 4gug by Molmil
1.62 Angstrom Crystal Structure of the Salmonella enterica 3-Dehydroquinate Dehydratase (aroD) E86A Mutant in Complex with Dehydroshikimate (Crystal Form #1)
分子名称: (4S,5R)-4,5-dihydroxy-3-oxocyclohex-1-ene-1-carboxylic acid, 3-dehydroquinate dehydratase, CHLORIDE ION
著者Light, S.H, Minasov, G, Duban, M.-E, Shuvalova, L, Kwon, K, Lavie, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2012-08-29
公開日2012-09-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Reassessing the type I dehydroquinate dehydratase catalytic triad: Kinetic and structural studies of Glu86 mutants.
Protein Sci., 22, 2013
4JLN
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Human dCK C4S-S74E mutant in complex with UDP and the F2.4.1 inhibitor (2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5-PROPYL-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE)
分子名称: 2-[({2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl}methyl)sulfanyl]pyrimidine-4,6-diamine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Nomme, J, Lavie, A.
登録日2013-03-12
公開日2014-01-22
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules.
Acta Crystallogr.,Sect.D, 70, 2014
2ZIA
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BU of 2zia by Molmil
C4S dCK variant of dCK in complex with cladribine+UDP
分子名称: 2-chloro-2'-deoxyadenosine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Sabini, E, Lavie, A.
登録日2008-02-13
公開日2008-07-08
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase
J.Med.Chem., 51, 2008

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