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PDB: 62 件
5FC2
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Structure of a separase in complex with a pAMK peptide containing a phospho-serine
分子名称: pAMK, peptide containing a phospho-serine, separase
著者Lin, Z, Luo, X, Yu, H.
登録日2015-12-14
公開日2016-03-30
最終更新日2016-05-04
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Structural basis of cohesin cleavage by separase.
Nature, 532, 2016
5FBY
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Crystal structure of ctSPD
分子名称: cleaved peptide, separase
著者Lin, Z, Luo, X, Yu, H.
登録日2015-12-14
公開日2016-03-30
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.898 Å)
主引用文献Structural basis of cohesin cleavage by separase.
Nature, 532, 2016
6AR0
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BU of 6ar0 by Molmil
Structure of human SLMAP FHA domain
分子名称: Sarcolemmal membrane-associated protein
著者Ni, L, Luo, X.
登録日2017-08-21
公開日2018-07-04
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.08 Å)
主引用文献SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.
Elife, 6, 2017
6AR2
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Structure of human SLMAP FHA domain in complex with pMST2
分子名称: ASP-GLY-TPO-MET-LYS-ARG, Sarcolemmal membrane-associated protein
著者Osinski, A, Ni, L, Luo, X.
登録日2017-08-21
公開日2018-07-04
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.
Elife, 6, 2017
5H25
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EED in complex with PRC2 allosteric inhibitor compound 11
分子名称: 5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED
著者Zhao, K, Zhao, M, Luo, X, Zhang, H.
登録日2016-10-14
公開日2017-01-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
5H24
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BU of 5h24 by Molmil
EED in complex with PRC2 allosteric inhibitor compound 8
分子名称: 5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED
著者Zhao, K, Zhao, M, Luo, X, Zhang, H.
登録日2016-10-14
公開日2017-01-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
2IW5
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BU of 2iw5 by Molmil
Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase
分子名称: AMMONIUM ION, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Yang, M, Gocke, C.B, Luo, X, Borek, D, Tomchick, D.R, Machius, M, Otwinowski, Z, Yu, H.
登録日2006-06-26
公開日2006-08-09
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献Structural Basis for Corest-Dependent Demethylation of Nucleosomes by the Human Lsd1 Histone Demethylase
Mol.Cell, 23, 2006
2QYF
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BU of 2qyf by Molmil
Crystal structure of the Mad2/p31(comet)/Mad2-binding peptide ternary complex
分子名称: MAD2L1-binding protein, Mitotic spindle assembly checkpoint protein MAD2A, peptide
著者Tomchick, D.R, Luo, X.
登録日2007-08-14
公開日2008-01-29
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献p31comet blocks Mad2 activation through structural mimicry.
Cell(Cambridge,Mass.), 131, 2007
7YDX
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BU of 7ydx by Molmil
Crystal structure of human RIPK1 kinase domain in complex with compound RI-962
分子名称: 1-methyl-5-[2-(2-methylpropanoylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-phenylethyl]indole-3-carboxamide, IODIDE ION, Receptor-interacting serine/threonine-protein kinase 1
著者Zhang, L, Wang, Y, Li, Y, Wu, C, Luo, X, Wang, T, Lei, J, Yang, S.
登録日2022-07-04
公開日2023-04-19
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.642 Å)
主引用文献Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor.
Nat Commun, 13, 2022
5WC2
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Crystal Structure of ADP-bound human TRIP13
分子名称: ADENOSINE-5'-DIPHOSPHATE, Pachytene checkpoint protein 2 homolog
著者Jeong, B.-C, Luo, X.
登録日2017-06-29
公開日2018-04-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing.
Nat Commun, 8, 2017
2VFX
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BU of 2vfx by Molmil
Structure of the Symmetric Mad2 Dimer
分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, CHLORIDE ION, ...
著者Yang, M, Li, B, Liu, C.-J, Tomchick, D.R, Machius, M, Rizo, J, Yu, H, Luo, X.
登録日2007-11-05
公開日2008-03-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Insights Into MAD2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric MAD2 Dimer.
Plos Biol., 6, 2008
6LO2
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Crystal structure of EED in complex with EZH2 peptide and compound 11#
分子名称: 8-[4-[(dimethylamino)methyl]phenyl]-N-[(2-methoxyphenyl)methyl]-[1,2,4]triazolo[4,3-a]pyridin-5-amine, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED
著者Zhao, K, Zhao, M, Luo, X, Zhang, H, Chen, Z.
登録日2020-01-02
公開日2021-07-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Structure of EED in complex with EZH2 peptide and cmpd20
To Be Published
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件を2024-08-07に公開中

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