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PDB: 62 件

6L1W
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Zinc-finger Antiviral Protein (ZAP) bound to RNA
分子名称: RNA (5'-R(*CP*GP*UP*CP*GP*U)-3'), ZINC ION, Zinc finger CCCH-type antiviral protein 1
著者Luo, X, Wang, X, Gao, Y, Zhu, J, Liu, S, Gao, G, Gao, P.
登録日2019-09-30
公開日2020-01-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.194 Å)
主引用文献Molecular Mechanism of RNA Recognition by Zinc-Finger Antiviral Protein.
Cell Rep, 30, 2020
3IMQ
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Crystal structure of the NusB101-S10(delta loop) complex
分子名称: 30S ribosomal protein S10, N utilization substance protein B, POTASSIUM ION
著者Luo, X, Wahl, M.C.
登録日2009-08-11
公開日2009-11-10
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Fine tuning of the E. coli NusB:NusE complex affinity to BoxA RNA is required for processive antitermination.
Nucleic Acids Res., 38, 2010
5HGU
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Crystal structure of human transcription factor TEAD2 in complex with palmitate
分子名称: PALMITIC ACID, Transcriptional enhancer factor TEF-4
著者Luo, X, Xiao, H.
登録日2016-01-08
公開日2016-02-17
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.046 Å)
主引用文献Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway.
Nat.Chem.Biol., 12, 2016
1KLQ
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The Mad2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes upon Binding to Either Mad1 or Cdc20
分子名称: MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A, Mad2-binding peptide
著者Luo, X, Tang, Z, Rizo, J, Yu, H.
登録日2001-12-12
公開日2002-01-25
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20.
Mol.Cell, 9, 2002
4ZUZ
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SidC 1-871
分子名称: SidC
著者Luo, X, Wasilko, D.J, Liu, Y, Sun, J, Wu, X, Luo, Z.-Q, Mao, Y.
登録日2015-05-18
公開日2015-07-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献Structure of the Legionella Virulence Factor, SidC Reveals a Unique PI(4)P-Specific Binding Domain Essential for Its Targeting to the Bacterial Phagosome.
Plos Pathog., 11, 2015
1S2H
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The Mad2 spindle checkpoint protein possesses two distinct natively folded states
分子名称: Mitotic spindle assembly checkpoint protein MAD2A
著者Luo, X, Tang, Z, Xia, G, Wassmann, K, Matsumoto, T, Rizo, J, Yu, H.
登録日2004-01-08
公開日2004-03-30
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献The Mad2 spindle checkpoint protein has two distinct natively folded states.
Nat.Struct.Mol.Biol., 11, 2004
1DUJ
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SOLUTION STRUCTURE OF THE SPINDLE ASSEMBLY CHECKPOINT PROTEIN HUMAN MAD2
分子名称: SPINDLE ASSEMBLY CHECKPOINT PROTEIN
著者Luo, X, Fang, G, Coldiron, M, Lin, Y, Yu, H.
登録日2000-01-17
公開日2000-03-08
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20.
Nat.Struct.Biol., 7, 2000
5BRM
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Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling
分子名称: MOB kinase activator 1A, Serine/threonine-protein kinase 3, ZINC ION
著者Luo, X, Ni, L.
登録日2015-05-31
公開日2015-07-08
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.651 Å)
主引用文献Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling.
Genes Dev., 29, 2015
4DZO
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Structure of Human Mad1 C-terminal Domain Reveals Its Involvement in Kinetochore Targeting
分子名称: Mitotic spindle assembly checkpoint protein MAD1
著者Luo, X, Sun, H, Tomchick, D.R.
登録日2012-03-01
公開日2012-04-11
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting.
Proc.Natl.Acad.Sci.USA, 109, 2012
1TBD
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SOLUTION STRUCTURE OF THE ORIGIN DNA BINDING DOMAIN OF SV40 T-ANTIGEN, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称: SV40 T-ANTIGEN
著者Luo, X, Sanford, D.G, Bullock, P.A, Bachovchin, W.W.
登録日1996-11-04
公開日1997-03-12
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure of the origin DNA-binding domain of SV40 T-antigen.
Nat.Struct.Biol., 3, 1996
4GGD
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Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.
分子名称: Cell division cycle protein 20 homolog, Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
著者Luo, X, Tian, W, Tomchick, D.R.
登録日2012-08-06
公開日2012-11-07
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.435 Å)
主引用文献Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GGA
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Structural Analysis of Human Cdc20 Supports Multi-site Degron Recognition by APC/C
分子名称: Cell division cycle protein 20 homolog
著者Luo, X, Tian, W, Tomchick, D.R.
登録日2012-08-06
公開日2012-11-07
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.044 Å)
主引用文献Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GGC
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Structural Analysis of Human Cdc20 Supports Multi-site Degron Recognition by APC/C
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, Cell division cycle protein 20 homolog
著者Luo, X, Tian, W, Tomchick, D.R.
登録日2012-08-06
公開日2012-11-07
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.
Proc.Natl.Acad.Sci.USA, 109, 2012
5XPI
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Structure of UHRF1 TTD in complex with NV01
分子名称: E3 ubiquitin-protein ligase UHRF1, N-[3-(diethylamino)propyl]-2-(12-methyl-9-oxidanylidene-5-thia-1,10,11-triazatricyclo[6.4.0.0^2,6]dodeca-2(6),3,7,11-tetraen-10-yl)ethanamide
著者Luo, X, Zhao, K.
登録日2017-06-02
公開日2018-04-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain
SLAS Discov, 23, 2018
3D3C
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Structural and functional analysis of the E. coli NusB-S10 transcription antitermination complex.
分子名称: 30S ribosomal protein S10, N utilization substance protein B
著者Luo, X, Wahl, M.C.
登録日2008-05-09
公開日2009-01-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural and functional analysis of the E. coli NusB-S10 transcription antitermination complex.
Mol.Cell, 32, 2008
4N14
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Crystal structure of Cdc20 and apcin complex
分子名称: 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl [(1R)-2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]carbamate, Cell division cycle protein 20 homolog
著者Luo, X, Tian, W, Yu, H.
登録日2013-10-03
公開日2014-08-20
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
Nature, 514, 2014
3D3B
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Structural and functional analysis of the E. coli NusB-S10 transcription antitermination complex.
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 30S ribosomal protein S10, N utilization substance protein B
著者Luo, X, Wahl, M.C.
登録日2008-05-09
公開日2009-01-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Structural and functional analysis of the E. coli NusB-S10 transcription antitermination complex.
Mol.Cell, 32, 2008
2TBD
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SV40 T ANTIGEN DNA-BINDING DOMAIN, NMR, 30 STRUCTURES
分子名称: SV40 T ANTIGEN
著者Luo, X, Sanford, D.G, Bullock, P.A, Bachovchin, W.W.
登録日1997-01-09
公開日1997-04-01
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure of the origin DNA-binding domain of SV40 T-antigen.
Nat.Struct.Biol., 3, 1996
4LG4
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Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5
分子名称: GLYCEROL, Serine/threonine-protein kinase 3
著者Luo, X, Ni, L, Tomchick, D.R.
登録日2013-06-27
公開日2013-09-18
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5.
Structure, 21, 2013
4LGD
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Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ras association domain family member 5, ...
著者Luo, X, Ni, L, Tomchick, D.R.
登録日2013-06-27
公開日2013-09-18
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5.
Structure, 21, 2013
5U36
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Crystal Structure Of A Mutant M. Jannashii Tyrosyl-tRNA Synthetase
分子名称: Tyrosine--tRNA ligase
著者Luo, X, Fu, G, Zhu, X, Wilson, I.A, Wang, F.
登録日2016-12-01
公開日2017-06-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria.
Nat. Chem. Biol., 13, 2017
5DQE
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Crystal structure of human transcription factor TEAD2 in complex with bromo-fenamic acid
分子名称: 2-[(3-bromophenyl)amino]benzoic acid, Transcriptional enhancer factor TEF-4
著者Han, X, Luo, X.
登録日2015-09-14
公開日2015-11-25
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.183 Å)
主引用文献Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.
Structure, 23, 2015
7QJU
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EED in complex with PRC2 allosteric inhibitor compound 7
分子名称: CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ...
著者Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C.
登録日2021-12-17
公開日2022-04-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J.Med.Chem., 65, 2022
7QJG
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EED in complex with PRC2 allosteric inhibitor compound 6
分子名称: CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-(2,3-dihydro-1-benzofuran-7-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ...
著者Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C.
登録日2021-12-16
公開日2022-04-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J.Med.Chem., 65, 2022
7QK4
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EED in complex with PRC2 allosteric inhibitor compound 22 (MAK683)
分子名称: CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ...
著者Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C.
登録日2021-12-17
公開日2022-04-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.602 Å)
主引用文献Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J.Med.Chem., 65, 2022

 

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