5XPI

Structure of UHRF1 TTD in complex with NV01

Summary for 5XPI

Entry DOI	10.2210/pdb5xpi/pdb
Descriptor	E3 ubiquitin-protein ligase UHRF1, N-[3-(diethylamino)propyl]-2-(12-methyl-9-oxidanylidene-5-thia-1,10,11-triazatricyclo[6.4.0.0^2,6]dodeca-2(6),3,7,11-tetraen-10-yl)ethanamide (3 entities in total)
Functional Keywords	ttd domain, small molecule, ligase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	18825.04
Authors	Luo, X.,Zhao, K. (deposition date: 2017-06-02, release date: 2018-04-25, Last modification date: 2023-11-22)
Primary citation	Senisterra, G.,Zhu, H.Y.,Luo, X.,Zhang, H.,Xun, G.,Lu, C.,Xiao, W.,Hajian, T.,Loppnau, P.,Chau, I.,Li, F.,Allali-Hassani, A.,Atadja, P.,Oyang, C.,Li, E.,Brown, P.J.,Arrowsmith, C.H.,Zhao, K.,Yu, Z.,Vedadi, M. Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain SLAS Discov, 23:930-940, 2018 Cited by PubMed: 29562800 DOI: 10.1177/2472555218766278 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation