3QBJ
| Crystal structure of dipeptidyl peptidase IV in complex with inhibitor | 分子名称: | 1-[(3S,4S)-4-amino-1-(6-phenylpyrimidin-4-yl)pyrrolidin-3-yl]piperidin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Liu, S.P. | 登録日 | 2011-01-13 | 公開日 | 2012-01-25 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Crystal structure of dipeptidyl peptidase IV in complex with inhibitor To be Published
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4EWS
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4KIK
| Human IkB kinase beta | 分子名称: | Inhibitor of nuclear factor kappa-B kinase subunit beta, K-252A | 著者 | Liu, S, Mosyak, L. | 登録日 | 2013-05-02 | 公開日 | 2013-06-26 | 最終更新日 | 2013-08-28 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Crystal Structure of a Human I kappa B Kinase beta Asymmetric Dimer. J.Biol.Chem., 288, 2013
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3S41
| Glucokinase in complex with activator and glucose | 分子名称: | Glucokinase, N,N-dimethyl-5-({2-methyl-6-[(5-methylpyrazin-2-yl)carbamoyl]-1-benzofuran-4-yl}oxy)pyrimidine-2-carboxamide, SODIUM ION, ... | 著者 | Liu, S. | 登録日 | 2011-05-18 | 公開日 | 2011-09-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus MEDCHEMCOMM, 2, 2011
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6BK8
| S. cerevisiae spliceosomal post-catalytic P complex | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Lea1, ... | 著者 | Liu, S, Li, X, Zhou, Z.H, Zhao, R. | 登録日 | 2017-11-07 | 公開日 | 2018-02-21 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of the yeast spliceosomal postcatalytic P complex. Science, 358, 2017
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2FYS
| Crystal structure of Erk2 complex with KIM peptide derived from MKP3 | 分子名称: | Dual specificity protein phosphatase 6, Mitogen-activated protein kinase 1 | 著者 | Liu, S, Sun, J.P, Zhou, B, Zhang, Z.Y. | 登録日 | 2006-02-08 | 公開日 | 2006-04-11 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3 Proc.Natl.Acad.Sci.Usa, 103, 2006
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4F2A
| Crystal structure of cholestryl esters transfer protein in complex with inhibitors | 分子名称: | (2R)-3-{[4-(4-chloro-3-ethylphenoxy)pyrimidin-2-yl][3-(1,1,2,2-tetrafluoroethoxy)benzyl]amino}-1,1,1-trifluoropropan-2-ol, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHLORIDE ION, ... | 著者 | Liu, S, Qiu, X. | 登録日 | 2012-05-07 | 公開日 | 2012-09-05 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | 主引用文献 | Crystal structures of cholesteryl ester transfer protein in complex with inhibitors. J.Biol.Chem., 287, 2012
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3VEY
| glucokinase in complex with glucose and ATPgS | 分子名称: | 6-methoxy-N-(1-methyl-1H-pyrazol-3-yl)quinazolin-4-amine, Glucokinase, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Liu, S. | 登録日 | 2012-01-09 | 公開日 | 2012-02-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS. J.Biol.Chem., 287, 2012
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8IVQ
| Cryo-EM structure of mouse BIRC6, Global map | 分子名称: | Isoform 2 of Baculoviral IAP repeat-containing protein 6 | 著者 | Liu, S, Jiang, T, Bu, F, Zhao, J, Wang, G, Li, N, Gao, N, Qiu, X. | 登録日 | 2023-03-28 | 公開日 | 2024-01-24 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Molecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy. Nat Commun, 15, 2024
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3VEV
| Glucokinase in complex with an activator and glucose | 分子名称: | (2S)-3-cyclopentyl-N-(5-methylpyridin-2-yl)-2-[2-oxo-4-(trifluoromethyl)pyridin-1(2H)-yl]propanamide, Glucokinase, SODIUM ION, ... | 著者 | Liu, S. | 登録日 | 2012-01-09 | 公開日 | 2012-02-08 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS. J.Biol.Chem., 287, 2012
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4NE9
| PCSK9 in complex with LDLR peptide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Low-density lipoprotein receptor, ... | 著者 | Liu, S. | 登録日 | 2013-10-28 | 公開日 | 2014-09-10 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro. Chem.Biol., 21, 2014
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1B6A
| HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH TNP-470 | 分子名称: | (1R,2S,3S,4R)-4-hydroxy-2-methoxy-4-methyl-3-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]cyclohexyl (chloroacetyl)carbamate, COBALT (II) ION, METHIONINE AMINOPEPTIDASE | 著者 | Liu, S, Clardy, J.C. | 登録日 | 1999-01-13 | 公開日 | 2000-01-13 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure of human methionine aminopeptidase-2 complexed with fumagillin. Science, 282, 1998
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3VF6
| Glucokinase in complex with glucose and activator | 分子名称: | 6-({(2S)-3-cyclopentyl-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]propanoyl}amino)pyridine-3-carboxylic acid, Glucokinase, SODIUM ION, ... | 著者 | Liu, S. | 登録日 | 2012-01-09 | 公開日 | 2012-02-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS. J.Biol.Chem., 287, 2012
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8FJP
| Cryo-EM structure of native mosquito salivary gland surface protein 1 (SGS1) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, salivary gland surface protein 1 | 著者 | Liu, S, Xia, X, Calvo, E, Zhou, Z.H. | 登録日 | 2022-12-20 | 公開日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Native structure of mosquito salivary protein uncovers domains relevant to pathogen transmission. Nat Commun, 14, 2023
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2LVN
| Structure of the gp78 CUE domain | 分子名称: | E3 ubiquitin-protein ligase AMFR | 著者 | Liu, S, Chen, Y, Huang, T, Tarasov, S.G, King, A, Li, J, Weissman, A.M, Byrd, R.A, Das, R. | 登録日 | 2012-07-09 | 公開日 | 2012-11-21 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Promiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin Chains. Structure, 20, 2012
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2LVO
| Structure of the gp78CUE domain bound to monubiquitin | 分子名称: | E3 ubiquitin-protein ligase AMFR, Ubiquitin | 著者 | Liu, S, Chen, Y, Huang, T, Tarasov, S.G, King, A, Li, J, Weissman, A.M, Byrd, R.A, Das, R. | 登録日 | 2012-07-09 | 公開日 | 2012-11-21 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Promiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin Chains. Structure, 20, 2012
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2LVP
| gp78CUE domain bound to the distal ubiquitin of K48-linked diubiquitin | 分子名称: | E3 ubiquitin-protein ligase AMFR, Ubiquitin | 著者 | Liu, S, Chen, Y, Huang, T, Tarasov, S.G, King, A, Li, J, Weissman, A.M, Byrd, R.A, Das, R. | 登録日 | 2012-07-09 | 公開日 | 2012-11-21 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Promiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin Chains. Structure, 20, 2012
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2LVQ
| gp78CUE domain bound to the proximal ubiquitin of K48-linked diubiquitin | 分子名称: | E3 ubiquitin-protein ligase AMFR, Ubiquitin | 著者 | Liu, S, Chen, Y, Huang, T, Tarasov, S.G, King, A, Li, J, Weissman, A.M, Byrd, R.A, Das, R. | 登録日 | 2012-07-09 | 公開日 | 2012-11-21 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Promiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin Chains. Structure, 20, 2012
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3SIU
| Structure of a hPrp31-15.5K-U4atac 5' stem loop complex, monomeric form | 分子名称: | NHP2-like protein 1, SULFATE ION, U4/U6 small nuclear ribonucleoprotein Prp31, ... | 著者 | Liu, S, Ghalei, H, Luhrmann, R, Wahl, M.C. | 登録日 | 2011-06-20 | 公開日 | 2011-08-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.626 Å) | 主引用文献 | Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31. Rna, 17, 2011
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3SIV
| Structure of a hPrp31-15.5K-U4atac 5' stem loop complex, dimeric form | 分子名称: | NHP2-like protein 1, U4/U6 small nuclear ribonucleoprotein Prp31, U4atac snRNA | 著者 | Liu, S, Ghalei, H, Luhrmann, R, Wahl, M.C. | 登録日 | 2011-06-20 | 公開日 | 2011-08-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.304 Å) | 主引用文献 | Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31. Rna, 17, 2011
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8FBD
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7EKP
| human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide, ... | 著者 | Liu, S, Zhao, Y, Sun, D, Tian, C. | 登録日 | 2021-04-06 | 公開日 | 2021-05-19 | 最終更新日 | 2021-06-16 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structural basis of human alpha 7 nicotinic acetylcholine receptor activation. Cell Res., 31, 2021
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7EKT
| human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 and PNU-120596 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide, ... | 著者 | Liu, S, Zhao, Y, Sun, D, Tian, C. | 登録日 | 2021-04-06 | 公開日 | 2021-05-19 | 最終更新日 | 2021-06-16 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | Structural basis of human alpha 7 nicotinic acetylcholine receptor activation. Cell Res., 31, 2021
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8JEU
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8JEC
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